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DEVELOPMENT OF A NEW DETECTION METHOD OF THE MINIMAL RESIDUAL TUMOR CELLS

Research Project

Project/Area Number 15590502
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory medicine
Research InstitutionKAWASAKI MEDICAL SCHOOL

Principal Investigator

TOHYAMA Kaoru  KAWASAKI MEDICAL SCHOOL, DPT OF LABORATORY MEDICINE, PROFFESOR, 医学部, 教授 (80227561)

Co-Investigator(Kenkyū-buntansha) ITOH Mitsuru  KAWASAKI MEDICAL SCHOOL, DPT OF LABORATORY MEDICINE, LECTURER, 医学部, 講師 (00360272)
Project Period (FY) 2003 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 2004: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2003: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywordsacute myeloid leukemia / blast / minimal residual tumor cells / flow cytometry / automated hematology analyzer / 白血病細胞 / 自動検出法
Research Abstract

Background : For the diagnosis and therapy of acute leukemia, it is important to detect a small number of leukemic cells precisely. Although several automated hematology analyzers that carry blast-detecting programs have been developed, they do not exert sufficient detection sensitivity to exceed the sensitivity of manual eye counting method. Methods: We constructed a new blast-detecting program by combining the numerical information acquired from five cytometric parameters presented by XE-2100. The sensitivity and specificity of this blast multi-scoring program were assessed in comparison with the‘Blasts' flag program equipped originally in XE-2100.
Results : The blast-detecting sensitivity was found to be highly improved in the blast multi-scoring program as compared with the‘Blasts' flag program without much reducing the specificity. A small number of leukemic myeloblasts were detected at the better sensitivity than the eye counting method in the clinical course of the patients with acute myeloid leukemia (AML).
Conclusions : The daily practical use of this blast multi-scoring program will surely contribute to sensitive, objective and real-time evaluation of the treatment of AML with a low cost.

Report

(3 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • Research Products

    (3 results)

All Other

All Journal Article (3 results)

  • [Journal Article] Improved Detection of Minimal Acute Myeloid Leukemia Cells by the Use of the Combined Parameters of XE-2100^<TM> Hematology Analyzer

    • Author(s)
      Kaoru Tohyama 他8名
    • Journal Title

      Cytometry (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Improved Detection of Minimal Acute Myeloid Leukemia Cells by he Use of the Combined Parameters of XE-2100^<TM> Hematology Analyzer

    • Author(s)
      Kaoru Tohyama, et al.
    • Journal Title

      Cytometry (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Improved Detection of Minimal Acute Myeloid Leukemia Cells by the Use of the Combined Parameters of XE-2100^<TM> Hematology Analyzer

    • Author(s)
      Kaoru Tohyama, 他8名
    • Journal Title

      Cytometry (in press)

    • Related Report
      2004 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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