Carcinogenicity of indium tin-oxide to the lung of Syrian golden hamsters following intermittent intratracheal instillations
| Project/Area Number |
15590514
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | KYUSHU UNIVERSITY |
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Principal Investigator |
TANAKA Akiyo Kyushu University, Hygiene, Assistant Professor, 大学院・医学研究院, 講師 (10136484)
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| Co-Investigator(Kenkyū-buntansha) |
HIRATA Miyuki Kyushu University, Hygiene, Research Associate, 大学院・医学研究院, 助手 (30156674)
OMURA Minoru Kyushu University, Hygiene, Research Associate, 大学院・医学研究院, 助手 (50243936)
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| Project Period (FY) |
2003 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2004: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2003: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | indium tin oxide / indium oxide / carcinogenicity / lung toxicity / intratracheal instillation / Syrian golden hamster / chronic toxicity |
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| Research Abstract |
ITO is a sintered alloy containing a large portion of indium oxide and a small portion of tin oxide. In this study, since the primary constitutive element of ITO is indium, we evaluated the pulmonary toxic effect of ITO and indium oxide (In_2O_3) when instilled repeatedly into the trachea of hamsters. Pulmonary toxicity was evaluated 0 week, 8 week and 16 week, 40 week, 78 week after the last instillation A significant increase in relative lung weight was observed in all the ITO or In_2O_3 treated groups compared with the control group during observation period. In present study, severe pulmonary inflammations and lung weight gain were observed in both the ITO and In_2O_3 groups throughout the experiment. The severity of these lesions were getting worse with the passage of time among the ITO- or In_2O_3 -treated hamsters. Furthermore, 3 pulmonary adenomas were observed in ITO groups. The present results clearly demonstrated that ITO and In_2O_3 particles caused pulmonary damage when repeated intratracheal instillations are given to hamsters. Further clarification is needed regarding the pulmonary clearance of these particles and their distribution in the extra pulmonary tissues where the accumulation of indium would result in toxicity.
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Report
(3 results)
Research Products
(6 results)
