| Project/Area Number |
15590544
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | National Institute for Longevity Sciences (2004)
Hamamatsu University School of Medicine (2003) |
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Principal Investigator |
NAKAMURA Mieko National Institute for Longevity Sciences, Department of Epidemiology Section of Nutritional Epidemiology, Section Chief, (研究所)・疫学研究部・栄養疫学研究室長 (30236012)
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| Co-Investigator(Kenkyū-buntansha) |
SUGIURA Minoru National institute of Fruit Tree Science Laboratory of Post-Harvest Physiology, Department of Citrus Research, Okitsu, Chief Researcher, 果樹研究所・カンキツ研究部, 主任研究員 (10355406)
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| Project Period (FY) |
2003 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 2004: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2003: ¥3,100,000 (Direct Cost: ¥3,100,000)
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| Keywords | Carotenoids / Antioxidants / Arterial Stiffness / Arteriosclerosis / Diabetes Mellitus / β-carotene / β-cryptoxanthin / Cross-sectional Study / βクリプトキサンチン / βカロチン / 脈波速度 |
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| Research Abstract |
Antioxidants are potentially beneficial in preventing vascular complications in diabetes because oxidative stress would be enhanced in such a condition and play an important role in vascular disorders. This study aimed to investigate whether brachial-ankle pulse wave velocity (baPWV) would be lower in the presence of high serum carotenoid concentrations stratified according to the glycemic state. A total of 297 men and 579 women between 30 and 70 years of age were analyzed cross-sectionally. Multivariate adjusted mean of baPWV in the highest tertile for β-carotene (1386 cm/s) was bwer than that in the lowest tertile (1432 cm/s) and that in the highest tertile for β-cryptoxanthin (1382 cm/s) was lower than that in the middle tertile (1424 cm/s) in the case of normal festing glucose. Similar inverse associations were observed in a group that included subjects with both impaired lasting glucose and diabetes, however, without statistical significance. The highest tertile ofcarotenoids was associated with a low risk for high baPWV (=<1680 cm/s). Age, sex and glycemic state adjusted odds ratio was 0.35 (95% CI 0.20-0.60) for β-carotene and 0.45 (0.27-0.77) for β-cryptoxanthin. Multivariate adjustment did not alter the results. In conclusion, an inverse association of baPWV with β-carotene and β-cryptoxanthin was observed independently of the glycemic state.
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