| Project/Area Number |
15590562
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | KANAZAWA MEDICAL UNIVERSITY |
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Principal Investigator |
YAMADA Yuichi Kanazawa Medical University, Faculty of Medicine, Professor, 医学部, 教授 (70158228)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIZAKI Masao Kanazawa Medical University, Faculty of Medicine, Associate Professor, 医学部, 助教授 (10184516)
HONDA Ryumon Kanazawa Medical University, Faculty of Medicine, Lecturer, 医学部, 講師 (60097441)
釣谷 伊希子 金沢医科大学, 医学部, 講師 (30159040)
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| Project Period (FY) |
2003 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2004: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2003: ¥2,500,000 (Direct Cost: ¥2,500,000)
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| Keywords | Alcohol consumption / genotype / ALDH2 / CYP2E1 / acetaldehyde / ADH2 |
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| Research Abstract |
The associations of urinary ethanol and acetaldehyde concentrations with the volume of alcohol consumed and the genotypes of ALDH2 and CYP2E1, and those with alcohol-related health effects, such as BP, serum hepatic enzymes, lipids, UA and glucose elevations, were analyzed in 200 middle-aged Japanese men randomly selected from a working population. Increases in alcohol consumption were significantly related to urinary ethanol concentrations, and urinary ethanol concentrations showed a strong correlation with urinary acetaldehyde concentrations. No significant effects of the genotypes of ALDH2 and CYP2E1 on those associations. Also, no significant effects of urinary acetaldehyde were observed on the alcohol-related health effects.
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