| Project/Area Number |
15590565
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Fukuoka University |
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Principal Investigator |
MIYAZAKI Motomobu Fukuoka University, Sch.Med., Associate Professor, 医学部, 助教授 (60299542)
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| Co-Investigator(Kenkyū-buntansha) |
UNE Hiroshi Fukuoka University, Sch.Med., Professor, 医学部, 教授 (40122676)
UESHIBA Hajime Toho University, Sch.of Med., Instructor, 医学部, 講師 (60232740)
MOMOSE Yoshito Fukuoka University, Sch.of Med., Assistant Professor, 医学部, 助手 (20123119)
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| Project Period (FY) |
2003 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2005: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2004: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2003: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | Ischemic heart disease / Non-obesity / Diabetes mellitus / Infectious disease / 血清脂質 |
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| Research Abstract |
The purpose of this case-control study was to elucidate risk factors for ischemic heart disease (IHD), the present study examined whether H.pylori infection or diabetes mellitus are a risk factor for patients with IHD. We studied 33 male patients with acute coronary syndromes (ACS) and 86 male patients with a 75% or greater stenosis of coronary arteries. All patients, who undergo coronary angiography, were incidence cases of IHD that they did not have a past history of IHD and were at the first onset of IHD. Controls were at random selected from outpatients. All controls had normal resting electrocardiogram and had no history of IHD. H.pylori seropositivity was determined by an IgG-specific enzyme linked immunosorbent assay (ELISA). We serologically confirmed the presence of antibodies specific to the antigen CagA of H.pylori, using CagA ELISA. The serum level of adiponectin was evaluated by solid phase ELISA. Seropositive rate of IgG antibodies in patients with ACS was 87.9%. A rate of in controls was 66.7%. After adjustment for age, a statistically significant association was found in H.pylori seropositivity between ACS and controls (OR, 3.74 ; 95% CI, 1.15-12.13). This relation was also significant after adjusted for potential confounding factors (OR, 4.09 ; 95% CI, 1.10-15.17). Anti-CagA positive H.pylori were significantly recognized in ACS (adjusted OR, 3.58 ; 95% CI, 1.08-11.82). However, this significant association was disappeared after adjusted for potential confounding factors(P=0.054). Decreasing levels of serum adiponectin were increasingly associated with a higher risk of coronary stenosis in a dose-dependent manner (p for trend P<0.001). We confirmed a significant link between H.pylori infection and ACS. H.pylori infection is likely to be a risk factor for ACS. The combination of low serum adiponectin levels and smoking was strongly associated with coronary stenosis.
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