| Co-Investigator(Kenkyū-buntansha) |
HIDA Ayumi Radiation Effects Research Foundation, Dept. of Clinical Studies, Division Chief(Research Scientist), 臨床研究部, 科長(研究員) (00359465)
IMAIZUMI Misa Radiation Effects Research Foundation, Dept. of Clinical Studies, Division Chief(Research Scientist), 臨床研究部, 科長(研究員) (10359466)
SETO Shinji Nagasaki University, Graduate School of Biomedical Sciences, Course of Medical and Dental Sciences, Associate Professor, 大学院・医歯薬学総合研究科, 助教授 (00136657)
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| Research Abstract |
Since 1958, the Nagasaki Laboratory of the Radiation Effects Research Foundation has been carrying out biennial health examinations targeting 7,564 A-bomb survivors (3,374 men and 4,190 women) for the purpose of conducting longitudinal research on the late effects of the atomic bombings. For reasons such as death or relocation (moving to another city) during the period from 1958 through 2003, 1,691 A-bomb survivors (586 men and 1,105 women) actually underwent the examinations in 2003 and 2004. The examinations conducted on these A-bomb survivors included the following items : Questionnaire survey, physical examination, height and weight, blood pressure, general blood test, biochemical tests (serum cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides, uric acid, blood sugar, CRP, and insulin), abdominal ultrasonography, electrocardiogram, and pulse wave velocity (PWV). Measurement of adiponectin was conducted in 325 out of the 1,691 A-bomb survivors. With increased degree of obe
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sity, blood pressure, triglycerides, LDL cholesterol, uric acid, fasting blood sugar, and HbAlc increased, whereas HDL-cholesterol level was low. HOMO-IR increased with increased degree of obesity, suggesting increased insulin resistance. Increased PWV values were observed among obese subjects, hinting that atherosclerosis had progressed with obesity. Obese subjects were likely to have fatty-liver complications including hypertension, hypertriglyceridemia, low HDL-cholesterol, abnormal glucose tolerance, and hyperuricemia, with lowered adiponectin levels. It was thus assumed that in fatty liver, decreased adiponectin had caused increased insulin resistance, which in turn invited such complications as hypertension, hypertriglyceridemia, low HDL-cholesterol, abnormal glucose tolerance, and hyperuricemia, finally inducing atherosclerosis. The possibility exists, therefore, that increased fatty liver through exposure to the atomic bombings promoted atherosclerosis among the A-bomb survivors, and that this had ultimately increased cases of myocardial infarction. Less
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