| Project/Area Number |
15590599
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | KYUSHU UNIVERSITY |
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Principal Investigator |
TAKII Masato Kyushu University, Department of Psychosomatic Medicine, Graduate School of Medical Sciences, Assistant Professor, 大学病院, 講師 (20294928)
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| Co-Investigator(Kenkyū-buntansha) |
NOZAKI Takehiro Kyushu University, Department of Psychosomatic Medicine, Graduate School of Medical Sciences, Research Associate, 大学病院, 助手 (60301339)
UCHIGATA Yasuko Tokyo Women's Medical School of Medicine, The Diabetes Center, Professor, 糖尿病センター, 教授 (50193884)
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| Project Period (FY) |
2003 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 2004: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2003: ¥1,100,000 (Direct Cost: ¥1,100,000)
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| Keywords | Type 1 diabetes / Diabetic complication / Eating disorder / Bulimia nervosa / Insulin omission / Diabetic retionpathy / Diabetic nephropathy / 糖尿病(性)合併症 / 糖尿病(性)網膜症 / 糖尿病(性)腎症 |
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| Research Abstract |
Concurrence of eating disorders and type 1 diabetes leads to an earlier development of diabetic microvascular complications. However, what features of eating disorders specifically lead to complications are unknown. We sought to determine the predictors of retinopathy and nephropathy in type 1 diabetic females with clinical eating disorders. Subjects were 109 type 1 diabetic females with clinical eating disorders diagnosed by the Structured Clinical Interview for DSM-IV ; bulimia nervosa (n=70), binge-eating disorder (n=28), anorexia nervosa (n=7), and eating disorder not otherwise specified (n=4). Retinopathy, advanced retinopathy (preproliferative and proliferative retinopathy), and nephropathy were screened and demographic, medical, and psychological/behavioral factors including the duration of various problematic behaviors related to eating disorders were investigated. To identify the predictors of each complication, logistic regression analysis was done. Of the various problematic behavioral factors related to eating disorders of type 1 diabetic females with clinical eating disorders, severe insulin omission was the most important predictor of retinopathy, advanced retinopathy, and nephropathy. Moreover, as has been reported for diabetes in general, the duration of diabetes was another predictor of these complications. In their management of type 1 diabetic females with clinical eating disorders, clinicians should focus their effort to prevent complications on having patients properly administer insulin.
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