| Project/Area Number |
15590637
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
IKUMA Mutsuhiro Hamamatsu University School of Medicine, Department of Medicine I, Assistant Professor, 医学部, 助手 (00275108)
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| Co-Investigator(Kenkyū-buntansha) |
KAJIMURA Masayoshi Hamamatsu University School of Medicine, Department of Medicine I, Lecturer, 医学部附属病院, 講師 (40252184)
KANAOKA Shigeru Hamamatsu University School of Medicine, Department of Emergency Medicine I, Assistant Professor, 医学部, 助手 (00252172)
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| Project Period (FY) |
2003 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2004: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2003: ¥2,300,000 (Direct Cost: ¥2,300,000)
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| Keywords | inflammatory bowel disease / mucosal immunology / intracellular calcium |
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| Research Abstract |
Intestinal epithelium award active barrier, which, as with its normal status, maintains regulated uptake of nutrients and fluids, and then are simultaneously excluding potential pathogens. Enteric diseases, including inflammatory bowel disease (IBD) cause disconcerted epithelial function. Although IBD seems to be born in idiopathic, it is obvious that the pathophysiology of the IBD is due to inopportune or exaggerated immunological reactions. Relatively few studies have demonstrated role of intracellular ion status and transmembrane ion movement on epithelial immune function. Several features, including technical matter, correspond to difficulties such studies. This booklet is devoted as report of the Japanese National Grant-in-Aid for Scientific Research (C) 'KAKENHI" #15590637 : "The study for intracellular calcium and ion dynamics in the regulation of intestinal immune cells" through 2003-2004 fiscal year. In the separately published synopsis I will illustrate the core of the study and review the current status of this area's advancement, along with our recent publications. What is conceivably most marked is the fact that we have only begun to recognize the role of anion transport mechanism and the contribution of the divalent cation (e.g., calcium) on that for the core cell function in the immune systems. The experience may lead to further advancement in this research fields.
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