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Primary biliary cirrhosis and estrogen-mediated regulation of CD4+CD25+ thymocyte differentiation.

Research Project

Project/Area Number 15590657
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionKochi Medical School

Principal Investigator

ONISHI Saburo  Kochi medical School, Gastroenterology and Hepatology, Professor, 医学部, 教授 (60136380)

Co-Investigator(Kenkyū-buntansha) SAIBARA Toshiji  Kochi medical School, Molecular Genetics, Associated professor, 医学部, 助教授 (60145125)
AKISAWA Naoaki  Kochi medical School, Gastroenterology and Hepatology, Research assistant, 医学部, 助手 (00322280)
Project Period (FY) 2003 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2004: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2003: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywordsgender / estrogen / thymocyte / differentiation / 原発性胆汁性肝硬変 / CD25 / GVH
Research Abstract

Primary biliary cirrhosis is an autoimmune liver disease with chronic nonsupprative destructive cholangitis (CNSDC). Middle aged-female is most sensitive to this disease. In thymus of estrogen deficient mice, CD3+TCRbeta high thymocytes and CD4+CD25+thymocytes are decreased in number though CD4+CD8+CD25+thymocytes are increased in number. These characteristic pathological features in estrogen deficient mice results in an evident increase of autoreactive T cells in aged mice possibly due to impaired maturation process of FOX3+ T cell. Exogeneous administration of estrogen abrogates these characteristic changes completely. Organ culture of thymus derived from estrogen deficient mice is a potent method to investigate the role of estrogen in the differentiation and maturation of thymocytes in vitro.

Report

(3 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • Research Products

    (22 results)

All 2004 2003 Other

All Journal Article (12 results) Publications (10 results)

  • [Journal Article] Polymorphisms in microsomal triglyceride transfer protein gene and manganese superoxide dismutase gene in Japanese patients with nonalcoholic steatohepatitis2004

    • Author(s)
      C.Namikawa, et al.
    • Journal Title

      J Hepatol 40

      Pages: 781-786

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Polymorphisms of interleukin 1β and β3-adrenergic receptor in Japanese patients with nonalcoholic steatohepatitis.2004

    • Author(s)
      Y.Nozaki, et al.
    • Journal Title

      Alcohol Clin Exp Res 28

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] CYP17 polymorphism as a risk factor of tamoxifen-induced hepatic steatosis in breast cancer patients2004

    • Author(s)
      T.Ohnishi, et al.
    • Journal Title

      Oncol Rep 13

      Pages: 465-489

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Polymorphisms of interleukin 1 beta and beta 3-adrenergic receptor in Japanese patients with nonalcoholic steatohepatitis.2004

    • Author(s)
      Y.Nozaki, et al.
    • Journal Title

      Alcohol Clin Exp Res 28

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Protective effect of 3-methyl-1-phenyl-2-pyrazolin-5-one, a free radical scavenger, on acute toxicity of paraquat in mice.2003

    • Author(s)
      Saibara T, et al.
    • Journal Title

      Toxicol Lett 143

      Pages: 51-54

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Pitavastatin ameliorates severe hepatic steatosis in aromatase-deficient (Ar-/-) mice.2003

    • Author(s)
      Egawa T, et al.
    • Journal Title

      Lipids 38

      Pages: 519-523

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A novel type hypertriglyceridemia observed in FLS mouse.2003

    • Author(s)
      Takahashi M, et al.
    • Journal Title

      Lipids 38

      Pages: 687-692

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Follow-up CT findings of tamoxifen-induced non-alcoholic steatohepatitis (NASH) of breast cancer patients treated with bezafibrate.2003

    • Author(s)
      Ogawa Y, et al.
    • Journal Title

      Oncol Rep 10

      Pages: 1473-1478

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Apoptotic-resistance of the human osteosarcoma cell line HS-Os-1 to irradiation is converted to apoptotic-susceptibility by hydrogen peroxide : A potent role of hydroperoxide as a new sensitizer.2003

    • Author(s)
      Ogawa Y, et al.
    • Journal Title

      Int J Molec Med 12

      Pages: 845-850

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Protective effect of 3-methyl-1-phenyl-2-pyrazolin-5- one, a free radical scavenger, on acute toxicity of paraquat in mice.2003

    • Author(s)
      Saibara T, et al.
    • Journal Title

      Toxicol Lett 143

      Pages: 51-54

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Pitavastatin ameliorates severe hepatic steatosis in aromatase-deficient (Ar-/-) mice.2003

    • Author(s)
      Egawa T, et al.
    • Journal Title

      Lipid 38

      Pages: 519-523

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Follow-up CT findings of tamoxifen-induced non-alcoholic steatohepat itis (NASH) of breast cancer patients treated with bezafibrate.2003

    • Author(s)
      Ogawa Y, et al.
    • Journal Title

      Oncol Rep 10

      Pages: 1473-1478

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Publications] Toda K, et al.: "Fenofibrate, a ligand for PPAR α, inhibits aromatase cytochrome P450 expression in the ovary of mouse"J Lipid Res. 44. 265-270 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Saibara T, et al.: "Protective effect of 3-methyl-1-phenyl-2-pyrazolin-5-one, a free radical scavenger, on acute toxicity of paraquat in mice"Toxicol Lett. 143. 51-54 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Jin YL, et al.: "Tissue remodeling following submassive hemorrhagic necrosis in rat livers induced by an intraperitoneal injection of dimethylnitorsamine"Virchows Arch. 442. 39-47 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kawai S, et al.: "Vinculin : a novel marler for quiescent and activated hepatic stellate cells in human and rat livers"Virchows Archiv. 443. 78-86 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Takeda K, et al.: "Progressive development of insulin resistance phenotype in male mice with complete aromatase (Cyp 19) deficiency"J Endocrinol. 176. 237-246 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Soga M, et al.: "Spontaneous development of hepatocellular carcinoma in the FLS with hereditary fatty liver"Cancer Lett. 196. 43-48 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Egawa T, et al.: "Pitavastatin ameliorates severe hepatic steatosis in aromatase-deficient (Ar-/-) mice"Lipids. 38. 519-523 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Takahashi M, et al.: "A novel type hypertriglyceridemia observed in FLS mouse"Lipids. 38. 687-692 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ogawa Y, et al.: "Follow-up CT findings of tamoxifen-induced non-alcoholic steatohepatitis (NASH) of breast patients treated with bezafibrate"Oncol Rep. 10. 1473-1478 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ogawa Y, et al.: "Apoptotic-resistance of the human osteosarcoma cell line HS-Os-1 to irradiation is converted to apoptotic-susceptibility by hydrogen peroxide : A potent role of hydroperoxide as a new sensitizer"Int J Molec Med. 12. 845-850 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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