| Project/Area Number |
15590669
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Gastroenterology
|
|---|
| Research Institution | Yokohama City University |
|---|
Principal Investigator |
NAKAJIMA Atsushi Yokohama City University, School of Medicine, Associate Prof., 大学院・医学研究科, 助教授 (30326037)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KIRIKOSHI Hiroyuki Yokohama City University, School of Medicine, Assistant, 医学部附属病院, 助手 (80347294)
|
|---|
| Project Period (FY) |
2003 – 2004
|
| Project Status |
Completed (Fiscal Year 2004)
|
| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2004: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2003: ¥2,900,000 (Direct Cost: ¥2,900,000)
|
|---|
| Keywords | PPARγ / cre-lox / Fabp / 性腸疾患 / 炎症性腸疾患 |
|---|
| Research Abstract |
The purpose of this research is to clarify the role of PPARγ-intestinal disease, especially the association with colon cancer carcinogenesis and Inflammatory Bowel Disease. In this research, we made the conditional knockout mouse of PPARγ in intestine (using cre-lox system). The intestine specific promoter Fatty Acid Binding Protein (FABP) was used for cre-transgenic mouse, also we created the lox-PPAR transgenic mouse. We are now analyzing cre-lox-PPARγ conditional.
|
