The role of PPAR γ in Gastrointestinal disease
| Project/Area Number |
15590669
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Yokohama City University |
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Principal Investigator |
NAKAJIMA Atsushi Yokohama City University, School of Medicine, Associate Prof., 大学院・医学研究科, 助教授 (30326037)
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| Co-Investigator(Kenkyū-buntansha) |
KIRIKOSHI Hiroyuki Yokohama City University, School of Medicine, Assistant, 医学部附属病院, 助手 (80347294)
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| Project Period (FY) |
2003 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2004: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2003: ¥2,900,000 (Direct Cost: ¥2,900,000)
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| Keywords | PPARγ / cre-lox / Fabp / 性腸疾患 / 炎症性腸疾患 |
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| Research Abstract |
The purpose of this research is to clarify the role of PPARγ-intestinal disease, especially the association with colon cancer carcinogenesis and Inflammatory Bowel Disease. In this research, we made the conditional knockout mouse of PPARγ in intestine (using cre-lox system). The intestine specific promoter Fatty Acid Binding Protein (FABP) was used for cre-transgenic mouse, also we created the lox-PPAR transgenic mouse. We are now analyzing cre-lox-PPARγ conditional.
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Report
(3 results)
Research Products
(21 results)
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[Journal Article] Efficacy of a Triple Therapy with Rabeprazole, Amoxicilin, and Faropenem as second-line Treatment after Failure of Initial Helicobacter pylori Eradication Therapy2005
Author(s)
Togawa J, Inamori M, Fujisawa N, Takahashi H, Yoneda M, Kawamura H, Abe Y, Kirikoshi H, Kobayashi N, Sakaguchi T, Takamura T, Nakajima A, Ueno N, Sekihara H
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Journal Title
Hepato-Gastroenterology 52
Pages: 645-648
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Marked Attenuation of Production of Collagen Type I from Cardiac Fibroblasts by Dehydroepiandrosterone.2005
Author(s)
Iwasaki T, Mukasa K, Yoneda M, Ito S, Yamada Y, Mori Y, Fujisawa N, Fujisawa T, Wada K, Sekihara H, Nakajima A
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Journal Title
Am J Physiol Endocrinol Metab. (投稿中)
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[Journal Article] A Novel Therapy for Acute Hepatitis Utilizing Dehydroepi androsterone in the Murine Model of Hepatitis.2004
Author(s)
Yoneda M, Wada K, Katayama K, Nakajima N, Iwasaki T, Osawa E, Mukasa K, Yamada Y, Blumberg RS, Sekihara H, Nakajima A.
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Journal Title
Biochemical Pharmacology 68
Pages: 2283-2289
Related Report
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[Journal Article] Protective effect of endogenous PPARγ against acute gastric mucosal lesions associated with ischemia-reperfusion.2004
Author(s)
Wada K, Nakajima A, Takahashi H, Yoneda M, Fujisawa N, Ohsawa E, Kadowaki T, Kubota N, Terauchi Y, Matsuhashi N, Saubermann LJ, Nakajima N, Blumberg RS
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Journal Title
Am J Physiol Gastrointest Liver Physiol. 287
Pages: 452-458
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