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Role of PPAR in the gastrointestinal function.

Research Project

Project/Area Number 15590680
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionDokkyo University School of Medicine

Principal Investigator

SHIMADA Tadahito  Dokkyo University, Schooll of Medicine Department of Medicine, Associate Professor, 医学部, 助教授 (10206170)

Co-Investigator(Kenkyū-buntansha) HIRAISHI Hideyuki  Dokkyo University, School of Medicine Department of Medicine, Professor, 医学部, 教授 (00199035)
YONEDA Masashi  Dokkyo University, School of Medicine Department of Medicine, Lecturer, 医学部, 講師 (30261407)
寺野 彰  獨協医科大学, 医学部, 教授 (50155470)
Project Period (FY) 2003 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2004: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2003: ¥2,400,000 (Direct Cost: ¥2,400,000)
KeywordsPPAR / Trefoil factor family / Stomach
Research Abstract

Peroxisome proliferator-activated receptor(PPAR) is a member of the nuclear receptor family transcription factors. Three PPAR subtypes are known at present, PPARα,PPARδ, and PPARγ. Among these PPAR subtypes, PPARγ is expressed in the adipose tissues at a high level and involved in the regulation of adipocyte differentiation. Gastrointestinal epithelial cells also express PPARγ at a significant level and reports suggested the role of PAPRγ in the regulation of cell proliferation and cell death. However it is not well understood whether PPARγ plays a role in the protection of gastrointestinal mucosa.
Trefoil factor family(TFF) is a group of secretary peptides critically involved in the defense and repair of gastrointestinal mucosa. We examined the effect of PPARγ activation on the expression of TFF in gastric epithelial cells, and found that, among three TFF subtypes (TFF1,TFF2,and TFF3), PPARγ activation leads to the up-regulation of TFF2 expression. By detailed promoter analysis, we found the presence of a functional peroxisome-proliferator responsive element(PPRE) within the promoter sequence of the human TFF2 gene. Thus, the results of the present study suggest that human TFF2 gene is a direct target of PPARγ, and that PPARγ is involved in the defense of gastric mucosa through the regulation of TFF2 expression

Report

(3 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • Research Products

    (17 results)

All 2005 2004 2003 Other

All Journal Article (11 results) Publications (6 results)

  • [Journal Article] Effect of central corticotropin releasing factor on hepatic circulation in rats.2005

    • Author(s)
      M.Yoneda et al.
    • Journal Title

      Gut 54

      Pages: 282-288

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] PPARγ mediates NSAIDs-induced upregulatien of TFF2 expression in gastric epithelial cells.2005

    • Author(s)
      T.Shimada et al.
    • Journal Title

      FEBS Letters 558

      Pages: 33-38

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] PPARγ mediates NSAIDs-induced upregulation of TFF2 expression in gastric epithelial cells.2004

    • Author(s)
      T.Shimada et al.
    • Journal Title

      FEBS Letters 558

      Pages: 33-38

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Indomethacin up-regulates TFF2 expression in gastric epithelial Cells.2004

    • Author(s)
      A.Koitabashi, T.Shimada, et al.
    • Journal Title

      Aliment Pharmacol Ther 20

      Pages: 171-176

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Intraportal nicotine infusion in rats decreases hepatic blood flow through endothelin-1 and both endothelin A and endothelin B receptors.2004

    • Author(s)
      T.Hashimoto, M.Yoneda, et al.
    • Journal Title

      Toxicology and Applied Pharmacology 196

      Pages: 1-10

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Indomethacin up-regulates TFF2 expression in gastric epithelial cells.2004

    • Author(s)
      A.Koitabashi, T.Shimada, et al.
    • Journal Title

      Aliment Pharmacol Ther 20

      Pages: 171-176

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Indomethacin up-regulates TFF2 expression in gastric epithelial cells2004

    • Author(s)
      A.Koitabashi, T.Shimada, et al.
    • Journal Title

      Aliment Pharmacol Ther 20

      Pages: 171-176

    • Related Report
      2004 Annual Research Report
  • [Journal Article] PPARγを介した胃粘膜上皮細胞TFF2発現誘導機序について2004

    • Author(s)
      島田忠人 他
    • Journal Title

      胃分泌研究会誌 36

      Pages: 41-44

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 胃の筋性緊張昂進のメカニズム2004

    • Author(s)
      米田政志 他
    • Journal Title

      綜合臨床 53

      Pages: 3006-3011

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Up-regulation of TFF expression by PPARγ ligands in gastric epithelial cells.2003

    • Author(s)
      T.Shimada et al.
    • Journal Title

      Aliment Pharmacol Ther 18

      Pages: 119-125

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effect of indomethacin on TFF expression in gastric epithelial cells.2003

    • Author(s)
      A.Koitabashi, T.Shimada
    • Journal Title

      Dokkyo J Med Sci 30

      Pages: 85-92

    • NAID

      110000008686

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Publications] T.Shimada et al.: "Up-regulation of TFF expression by PPARγ ligands in gastric epithelial cells."Aliment Pharmacol Ther. 18(Suppl.1). 119-125 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] T.Shimada et al.: "PPARγ mediates NSAID-induced upregulation of TFF2 expression in gastric epithelial cells."FEBS Letters. 558. 33-38 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] M.Yoneda et al.: "Regulation of hepatic function by brain neuropeptides."Current Topics in Peptide & Protein Research. 5. 97-100 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] A.Koitabashi, T.Shimada: "Effect of indomethacin on TFF expression in gastric epithelial cells."Dokkyo J Med Sci. 30. 85-92 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 平石秀幸 他: "NSAIDs胃潰瘍の予防と治療のエビデンスとガイドライン"消化器科. 37. 372-379 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 島田忠人 他: "プロトンポンプを標的とした胃粘膜病態制御"医学の歩み. 208. 428-432 (2004)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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