Ghrelin dynamics during the development of H.pylori-associated gastritis. - a novel possible non-invasive diagnostic marker for gastritis -

• Project/Area Number: 15590686
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Keio University
• Principal Investigator: SUZUKI Hidekazu Keio University, Department of Internal Medicine, Assistant Professor, 医学部, 講師 (70255454)
• Co-Investigator(Kenkyū-buntansha): KANGAWA Kenji National Cardiovascular Center Research Institute, Department of Biochemistry, Director, 京都大学附属病院探索医療センター, 部長・教授(併任) (00112417)
• Project Period (FY): 2003 – 2004
• Project Status: Completed (Fiscal Year 2004)
• Budget Amount: ¥3,500,000 (Direct Cost: ¥3,500,000); Fiscal Year 2004: ¥800,000 (Direct Cost: ¥800,000); Fiscal Year 2003: ¥2,700,000 (Direct Cost: ¥2,700,000)
• Keywords: Helicobacter pylori / Ghrelin / Mongolian gerbil / Chronic gastritis / Gastric atrophy / Pepsinogen / myeloperoxidase / body weight / 摂食

Research Abstract

Although ghrelin, a novel growth hormone-releasing peptide, localized mainly in the gastric fundus, is reported not only to accelerate food passage and gastrointestinal motility, but also to affect appetite and weight control, the regulation of gastric ghrelin secretion under the condition of gastric Helicobacter pylori(Hp) infection remains unknown.
Study 1 : To investigate the plasma and gastric ghrelin levels in Mongolian gerbils with Hp colonization of the gastric mucosa.
Methods. Gerbils orally inoculated with Hp were examined after the inoculation. To examine preproghrelin mRNA expression in the gastric mucosa, the cDNA encoding the gerbil preproghrelin and GAPDH homologue was isolated and a quantitative RT-PCR system was established. Results. In the gerbils showing Hp colonization (Hp group), the expression of preproghrelin mRNA and the total ghrelin levels were significantly decreased 17 and 23 weeks later (p<0.01). Although the number of ghrelin-immunoreactive cells decreased, a s the stomach weight increased, the gastric contents of total and active ghrelin in this group were the same as those in the controls. The gastric myeloperoxidase activity showed a positive correlation with the plasma ghrelin level. On the other hand, at 17 weeks, the plasma ghrelin level was significantly increased in the Hp group (p<0.05), suggesting a compensatory increase in the secretion of this peptide at this time-point. Conclusion. Gastric and plasma ghrelin dynamics was altered in response to Hp infection.
Study 2 : To investigate the correlation between the plasma ghrelin levels and the extent of gastric mucosal atrophy in patients with chronic gastritis caused by H.pylori infection. Patients and Methods. Sixty-nine patients with dyspeptic symptoms were enrolled for the study. Of these, 41 patients were confirmed to become negative for H.pylori after therapy to eradicate the infection. The other 28 patients were diagnosed as positive for H.pylori infection. Blood samples were collected from all the patients after 12 hours' fasting, before upper GI endoscopy was performed. The plasma levels of total and active ghrelin, as well as the serum levels of pepsinogen I (PGI) and pepsinogen II (PGII) were measured by radioimmunoassay. Based on endoscopic assessment, the atrophic changes in the gastric mucosa were classified as open-type atrophy or closed-type atrophy.
Results. There were no significant differences in the plasma total and active ghrelin levels between H.pylori-positive and H.pylori-eradicated (negative) patients. The serum levels of PGI were correlated well with the plasma levels of total ghrelin and active ghrelin. The ratio of serum PGI to PGII level(PG I/II ratio) was also correlated well with the plasma level of total ghrelin and active ghrelin. The plasma levels of total as well as active ghrelin were significantly decreased in patients with low PG levels as compared with those in patients with high PG levels(PG I>70ng/ml or PG I/II>3.0). The plasma levels of total as well as active ghrelin were also significantly decreased in patients with endoscopically diagnosed open-type atrophy as compared with those in patients with endoscopically diagnosed closed-type atrophy(p<0.01), especially in the H. pylori-eradicated cohorts.
Conclusion. The plasma levels of ghrelin, which were correlated well with the serum levels of PG I as well as the PGI/II ratio, decreased with increasing extent of gastric mucosal atrophy, suggesting that it could be a potentially useful additional marker for chronic atrophic gastritis.

Research Products

• [Journal Article] Novel effects other than anti-secretory action and off-label use of proton pump inhibitors. (2005)
  • Author(s): Suzuki, H., Hibi, T.
  • Journal Title: Expert Opinion on Pharmacotherapy 6(1) Pages: 59-67
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Long-term strict monitoring of plasma ghrelin and other serological markers of gastric diseases after Helicobacter pylori eradication. (2005)
  • Author(s): Masaoka, T., Suzuki, H.et al.
  • Journal Title: Hepato-Gastroenterology 52(61) Pages: 1-4
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Effect of dietary anti-urease immunoglobulin Y on Helicobacter pylori infection in Mongolian gerbils. (2005)
  • Author(s): Nomura, S., Suzuki, H.et al.
  • Journal Title: Helicobacter 10(1) Pages: 43-52
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Role of nociceptin/orphanin FQ (Noc/oFQ) in murine experimental colitis. (2005)
  • Author(s): Kato, S., Suzuki, H.et al.
  • Journal Title: Journal of Neuroimmunology 161(1-2) Pages: 21-28
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Downregulation of a morphogen gradient in the gastric epithelium of Helicobacter pylori-infected Mongolian gerbils. (2005)
  • Author(s): Suzuki, H. et al.
  • Journal Title: Journal of Pathology 206 Pages: 186-197
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Enhanced ghrelin secretion in rats with cysteamine-induced duodenal ulcers. (2005)
  • Author(s): Fukuhara, S., Suzuki, H.et al.
  • Journal Title: American Journal of Physiology : Gastrointestinal and Liver Physiology (Epub)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Retinoic acid formation from retinol in the human gastric mucosa : a role of Class TV alcohol dehydrogenase and its relevance to morphological changes. (2005)
  • Author(s): Matsumoto, M., Suzuki, H.et al.
  • Journal Title: American Journal of Physiology : Gastrointestinal and Liver Physiology (Epub)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Does Helicobacter pylori attack ghrelin-producing cells? (2005)
  • Author(s): Suzuki, H., Hibi, T.
  • Journal Title: Journal of Gastroenterology 40 Pages: 437-439
  • NAID: 10015710261
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Enhanced plasma ghrelin levels in H.pylori-colonized, interleukin-1 receptor type 1-homozygous knockout (IL-1R1^<-/->) mice. (2005)
  • Author(s): Abiko, Y., Suzuki, H.et al.
  • Journal Title: World Journal of Gastroenterology (in press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Biomarkers in patients with gastric inflammation : a systematic review (2005)
  • Author(s): Naito, Y., Suzuki, H., et al.
  • Journal Title: Digestion (in press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Improvement of gastrointestinal quality of life (QOL) scores in cases of Helicobacter pylori-positive functional dyspepsia after successful eradication therapy. (2005)
  • Author(s): Suzuki, H., et al.
  • Journal Title: Journal of Gastroenterology and Hepatology (in press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Investigation of the possibility of human-beta defensin 2 (hBD2) as a molecular marker of gastric mucosal inflammation. (2005)
  • Author(s): Ohara, T., Suzuki, H., et al.
  • Journal Title: Hepato-Gastroenterology (in press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Novel effects other than anti-secretory action and off-label use of proton pump inhibitors. (2005)
  • Author(s): Suzuki, H., Hibi, T.
  • Journal Title: Expert.Opin.Pharmacother. 6(1) Pages: 59-67
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Long-term strict monitoring of plasma ghrelin and other serological markers of gastric diseases after Helicobacter pylori eradication. (2005)
  • Author(s): Masaoka, T., Suzuki, H., Imaeda, H., Hosoda, H., Ohara, T., Morishita, T., Ishii, H., Kangawa, K., Hibi, T.
  • Journal Title: Hepatogastroenterol. 52 Pages: 1-4
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effect of dietary antiurease immunoglobulin Y on Helicobacterpylori infection in Mongolian gerbils. (2005)
  • Author(s): Nomura, S., Suzuki, H., Masaoka, T., Kurabayashi, K., Ishii, H., Kitajima, M., Nomoto, K., Hibi, T.
  • Journal Title: Helicobacter 10(1) Pages: 43-52
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Role of nociceptin/orphanin FQ (Noc/oFQ) in murine experimental colitis. (2005)
  • Author(s): Kato, S., Tsuzuki, Y., Hokari, R., Okada, Y., Miyazaki, J., Matsuzaki, K., Iwai, A., Kawaguchi, A., Nagao, S., Itoh, K., Suzuki, H., Nabeshima, T., Miura, S.
  • Journal Title: J.Neuroimmunol. 161(1-2) Pages: 21-28
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Downregulation of a morphogen gradient in the gastric epithelium of Helicobacter pylori-infected Mongolian gerbils. (2005)
  • Author(s): Suzuki, H., Miriegishi, Y., Nomoto, K., Ota, T., Masaoka, T., van den Brink, G.R., Hibi, T.
  • Journal Title: J.Pathol. 206(2) Pages: 186-197
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Enhanced Ghrelin Secretion in Rats with Cysteamine-induced Duodenal Ulcers. (2005)
  • Author(s): Fukuhara, S., Suzuki, H., Masaoka, T., Arakawa, M., Hosoda, H., Minegishi, Y., Kangawa, K., Ishii, H., Kitajima, M., Hibi, T.
  • Journal Title: Am.J.Physiol., GI.Liver[Epub].
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Retinoic acid formation from retinol in the human gastric mucosa : a role of Class IV alcohol dehydrogenase and its relevance to morphological changes. (2005)
  • Author(s): Matsumoto, M., Yokoyama, H., Suzuki, H, Shiraishi, H., Hibi, T.
  • Journal Title: Am.J.Physiol., GI.Liver[Epub].
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Does Helicobacter pylori attack ghrelin-producing cells? (2005)
  • Author(s): Suzuki, H., Hibi, T.
  • Journal Title: J.Gastroenterol. 40(4) Pages: 437-439
  • NAID: 10015710261
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Long-term strict monitoring of plasma ghrelin and other serological markers of gastric diseases after Helicobactor pylori eradication. (2005)
  • Author(s): Masaoka, T., Suzuki, H.et al.
  • Journal Title: Hepato-Gastroenterology 52(61) Pages: 1-4
• [Journal Article] Helicobacter pylori infection modifies gastric and plasma ghrelin dynamics in Mongolian gerbils. (2004)
  • Author(s): Suzuki, H. et al.
  • Journal Title: Gut 53(2) Pages: 187-194
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Lansoprazole promotes gastric mucosal cell proliferation and migration by activating P44/P42 mitogen-activated protein kinase. (2004)
  • Author(s): Suzuki, H. et al.
  • Journal Title: Wound Repair and Regeneration 12(1) Pages: 93-99
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Usefulness of proton pump inhibitor (PPI) maintenance therapy for patients with H.pylori-negative recurrent peptic ulcer after eradication therapy for H.pylori. (2004)
  • Author(s): Ohara, T., Suzuki, H.et al.
  • Journal Title: Hepato-Gastroenterology 51(56) Pages: 338-342
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Down-regulation of matrix-invasive potential of human liver cancer cells by type I interferon and a histone deacetylase inhibitor sodium butyrate. (2004)
  • Author(s): Kaneko, F., Suzuki, H.et al.
  • Journal Title: International Journal of Oncology 24(4) Pages: 837-845
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Recurrent peptic ulcers in patients following successful Helicobacter pylori eradication. : a multicenter study of 4940 patients. (2004)
  • Author(s): Miwa, H., Suzuki, H.et al.
  • Journal Title: Helicobacter 9(1) Pages: 9-16
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Regular hemodialysis reverses gastric mucosal atrophy of patients with chronic renal failure. (2004)
  • Author(s): Ohara, T., Suzuki, H.et al.
  • Journal Title: Hepato-Gastroenterology 51(57) Pages: 679-683
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] ^<13>C-ethanol breath test reveals impaired alcohol metabolism in patients with Helicobacter pylori- infection. (2004)
  • Author(s): Suzuki, M., Suzuki, H.et al.
  • Journal Title: Alimentary Pharmacology and Therapeutics 20(1) Pages: 109-115
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] High prevalence of Helicobacter pylori resistance to clarithromycin during long-term multiple antibiotic therapy for chronic respiratory disease caused by non-tuberculosis mycobacteria. (2004)
  • Author(s): Kaneko, F., Suzuki, H.et al.
  • Journal Title: Alimentary Pharmacology and Therapeutics 20(Suppl.1) Pages: 62-67
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Second-line treatment of Helicobacter pylori infection after dilution agar methods and PCR-RFLP analysis. (2004)
  • Author(s): Masaoka, T., Suzuki, H.et al.
  • Journal Title: Alimentary Pharmacology and Therapeutics 20(Suppl.1) Pages: 68-73
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Helicobacter pylori-eradication treatment modulates epithelial cell proliferation and tissue content of hepatocyte growth factor in the gastric mucosa. (2004)
  • Author(s): Suzuki, M., Suzuki, H.et al.
  • Journal Title: Alimentary Pharmacology and Therapeutics 20(Suppl.1) Pages: 158-164
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Effect of dietary anti-Helicobacter pylori - urease immunoglobulin Y on Helicobacter pylori infection. (2004)
  • Author(s): Suzuki, H. et al.
  • Journal Title: Alimentary Pharmacology and Therapeutics 20(Suppl.1) Pages: 185-192
  • NAID: 10012749588
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Plasma ghrelin concentration correlates with the levels of serum pepsinogen I and pepsinogen I/II ratio - a possible novel and non-invasive marker for gastric atrophy. (2004)
  • Author(s): Suzuki, H. et al.
  • Journal Title: Hepato-Gastroenterology 51(59) Pages: 1249-1254
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Autoimmune pancreatitis with pseudocysts. (2004)
  • Author(s): Nishimura, T., Suzuki, H.et al.
  • Journal Title: Journal of Gastroenterology 39(10) Pages: 1005-1010
  • NAID: 10013798299
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Pathophysiological role of human β-defensins 2 in gastric mucosa. (2004)
  • Author(s): Ohara, T., Suzuki, H.et al.
  • Journal Title: International Journal of Molecular Medicine 14(6) Pages: 1023-1027
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Limited capability of regional lymph nodes to eradicate metastatic cancer cells. (2004)
  • Author(s): Nagata, H., Suzuki, H.et al.
  • Journal Title: Cancer Research 64(22) Pages: 8239-8248
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Antibiotics directly induce apoptosis in B cell lymphoma cells derived from BALB/c mice. (2004)
  • Author(s): Ohara, T., Suzuki, H.et al.
  • Journal Title: Anticancer Research 24(6) Pages: 3723-3730
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Helicobacter pylori infection modifies gastric and plasma ghrelin dynamics in Mongolian gerbils. (2004)
  • Author(s): Suzuki, H., Masaoka, T., Hosoda, H., Ota, T., Minegishi, Y., Nomura, S., Kangawa, K., Ishii, H.
  • Journal Title: Gut 53(2) Pages: 187-194
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Lansoprazole promotes gastric mucosal cell proliferation and migration by activating P44/P42 mitogen-activated protein kinase. (2004)
  • Author(s): Suzuki, H., Masaoka, T., Minegishi, Y., Motosugi, Y., Miura, S., Ishii, H.
  • Journal Title: Wound Repair.Regen. 12(1) Pages: 93-99
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Usefulness of proton pump inhibitor (PPI) maintenance therapy for patients with H.pylori-negative recurrent peptic ulcer after eradication therapy for H.pylori : pathophysiological characteristics of H.pylori-negative recurrent ulcer scars and beyond acid suppression by PPI. (2004)
  • Author(s): Ohara, T., Morishita, T., Suzuki, H., Masaoka, T., Ishii, H.
  • Journal Title: Hepatogastroenterol. 51(56) Pages: 338-342
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Down-regulation of matrix-invasive potential of human liver cancer cells by type I interferon and a histone deacetylase inhibitor sodium butyrate. (2004)
  • Author(s): Kaneko, F., Saito, H., Saito, Y., Wakabayashi, K., Nakamoto, N., Tada, S., Suzuki, H., Tsunematsu, S., Kumagai, N., Ishii, H.
  • Journal Title: Int.J.Oncol. 24(4) Pages: 837-845
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Recurrent peptic ulcers in patients following successful Hellcobacterpylofl eradication. : a multicenter study of 4940 patients. (2004)
  • Author(s): Miwa, H., Sakaki, N., Sugano, K., Sekine, H., Higuchi, K., Uemura, N., Kato, M., Murakami, K., Kato, C., Shiotani, A., Ohkusa, T., Takagi, A., Aoyama, N., Haruma, K., Okazaki, K., Kusugami, K., Suzuki, M., Joh, T., Azuma, T., Yanaka, A., Suzuki, H., Hashimoto, H., Kawai, T., Sugiyama, T.
  • Journal Title: Helicobacter 9 Pages: 9-16
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Regular hemodialysis reverses gastric mucosal atrophy of patients with chronic renal failure. (2004)
  • Author(s): Ohara, T., Suzuki, H., Kanoh, Y., Moriya, R., Okayasu, I., Morishita, T., Ishii, H.
  • Journal Title: Hepatogastroenterol. 51(57) Pages: 679-683
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] ^<13>C-ethanol breath test reveals impaired alcohol metabolism in patients with Helicobacter pylori- infection. (2004)
  • Author(s): Suzuki, M., Maruyama, K., Suzuki, H, Ishii, H.
  • Journal Title: Aliment.Pharm.Ther. 20(1) Pages: 109-115
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] High prevalence of Helicobacter pylori resistance to clarithromycin during long-term multiple antibiotic therapy for chronic respiratory disease caused by non-tuberculosis mycobacteria. (2004)
  • Author(s): Kaneko, F., Suzuki, H., Hasagawa, N., Kurabayashi, K., Saito, H., Otani, S., Nakamizo, H., Kawata, K., Miyairi, M., Ishii, K., Ishii, H.
  • Journal Title: Aliment.Pharm.Ther. 20 (Suppl.1) Pages: 62-67
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Second-line treatment of Helicobacter pylori infection after dilution agar methods and PCR-RFLP analysis. (2004)
  • Author(s): Masaoka, T., Suzuki, H., Kurabayashi, K., Kamiya, AG., Ishii, H.
  • Journal Title: Aliment.Pharm.Ther. 20 (Suppl.1) Pages: 68-73
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Helicobacter pylori-eradication treatment modulates epithelial cell proliferation and tissue content of hepatocyte growth factor in the gastric mucosa. (2004)
  • Author(s): Suzuki, M., Suzuki, H., Masaoka, T., Tanaka, S., Suzuki, K., Ishii, H.
  • Journal Title: Aliment.Pharm.Ther. 20 (Suppl.1) Pages: 158-164
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effect of dietary anti-Helicobacter pylori-urease immunoglobulin Y on Helicobacter pylori infection. (2004)
  • Author(s): Suzuki, H., Nomura, S., Masaoka, T., Goshima, H., Kamata, N., Kodama, Y., Ishii, H., Kitajima, M., Nomoto, K., Hibi, T.
  • Journal Title: Aliment.Pharm.Ther. 20 (Suppl.1) Pages: 185-192
  • NAID: 10012749588
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Plasma ghrelin concentration correlates with the levels of serum pepsinogen I and pepsinogen I/II ratio - a possible novel and non-invasive marker for gastric atrophy. (2004)
  • Author(s): Suzuki, H., Masaoka, T., Hosoda, H., Nomura, S., Ohara, T., Kangawa, K., Ishil, H., Hibi, T.
  • Journal Title: Hepatogastroenterol. 51 Pages: 1249-1254
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Autoimmune pancreatitis with pseudocysts. (2004)
  • Author(s): Nishimura, T., Masaoka, T., Suzuki, H., Aiura, K., Nagata, H., Ishli, H.
  • Journal Title: J.Gastroenterol. 39 Pages: 1005-1010
  • NAID: 10013798299
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Pathophysiological role of human β-defensins 2 in gastric mucosa. (2004)
  • Author(s): Ohara, T., Morishita, T., Suzuki, H., Nagata, H., Hibi, T.
  • Journal Title: Int.J.Mol.Med. 14(6) Pages: 1023-1027
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Limited capability of regional lymph nodes to eradicate metastatic cancer cells. (2004)
  • Author(s): Nagata, H., Arai, T., Soejima, Y., Suzuki, H., Ishli, H., Hibi, T.
  • Journal Title: Cancer Res. 64(22) Pages: 8239-8248
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Antibiotics directly induce apoptosis in B cell lymphoma cells derived from BALB/c mice. (2004)
  • Author(s): Ohara, T., Morishita, T., Suzuki, H., Masaoka, T., Ishli, H.
  • Journal Title: Anticancer Res. 24 Pages: 3723-3730
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Usefulness of proton pump inhibitor(PPI) maintenance therapy for patients with H. pylori-negative recurrent peptic ulcer after eradication therapy for H. pylori. (2004)
  • Author(s): Ohara, T., Suzuki, H.et al.
  • Journal Title: Hepato-Gastroenterology 51(56) Pages: 338-342
• [Journal Article] ^<13>C-ethanol breath test reveals impaired alcohol metabolism in patients with Helicobacter pylori-infection. (2004)
  • Author(s): Suzuki, M., Suzuki, H.et al.
  • Journal Title: Alimentary Pharmacology and Therapeutics 20(1) Pages: 109-115
• [Journal Article] High prevalence of Helicobacter pylori resistance to clarithromycin during long-term multiple antibiotic therapy for chronic respiratory disease caused by non-tuberculosis mycobacterium. (2004)
  • Author(s): Kaneko, F., Suzuki, H.et al.
  • Journal Title: Alimentary Pharmacology and Therapeutics 20(Suppl.1) Pages: 62-67
• [Journal Article] Effect of dietary anti-Helicobacter pylori-urease immunoglobulin Y on Helicobacter pylori infection. (2004)
  • Author(s): Suzuki, H. et al.
  • Journal Title: Alimentary Pharmacology and Therapeutics 20(Suppl.1) Pages: 185-192
  • NAID: 10012749588
• [Journal Article] Autoimmune pancreatitis with pseudocysts, resistant to therapy. (2004)
  • Author(s): Nishimura, T., Suzuki, H.et al.
  • Journal Title: Journal of Gastroenterology 39(10) Pages: 1005-1010
• [Journal Article] A pathophysiological role of human β-defensins 2 and 4 in the gastric mucosa. (2004)
  • Author(s): Ohara, T., Suzuki, H.et al.
  • Journal Title: International Journal of Molecular Medicine 14(6) Pages: 1023-1027
• [Journal Article] Significant role of ceramide pathway in experimental gastric ulcer formation in rats. (2003)
  • Author(s): Uehara, K., Suzuki, H.et al.
  • Journal Title: The Journal of Pharmacology and Experimental Therapeutics 305(1) Pages: 232-239
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Enhanced plasma ghrelin levels in rats wit streptozotocin-induced diabetes. (2003)
  • Author(s): Masaoka, T., Suzuki, H.et al.
  • Journal Title: FEBS Letters 541(1-3) Pages: 64-68
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Suppressed apoptosis in the inflamed gastric mucosa of H.pylori-colinized iNOS knockout mice. (2003)
  • Author(s): Miyazawa, M., Suzuki, H.et al.
  • Journal Title: Free Radical Biology and Medicine 34(12) Pages: 1621-1630
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Rabeprazole treatment attenuated H.pylori-associated gastric mucosal lesion formation in Mongolian gerbils. (2003)
  • Author(s): Suzuki, H. et al.
  • Journal Title: Journal of Gastroenterology and Hepatology 18(7) Pages: 787-795
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Helicobacter pylori-eradication therapy inhibits neutrophil-derived oxidants in the ulcerous mucosa in the human stomach : Relationship between ulcer stage and mucosal oxidant level. (2003)
  • Author(s): Suzuki, M., Suzuki, H.et al.
  • Journal Title: Digestive Endoscopy 15(4) Pages: 270-274
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Current consensus on the diagnosis and treatment of H.pylori-associated gastroduodenal disease. (2003)
  • Author(s): Suzuki, H. et al.
  • Journal Title: Keio Journal of Medicine 52(3) Pages: 163-173
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Perform and granzyme B of cytotoxic T lymphocyte mediate apoptosis irrespective of Helicobacter pylori infection : possible act as a trigger of peptic ulcer formation. (2003)
  • Author(s): Ohara, T., Suzuki, H.et al.
  • Journal Title: Hepato-Gastroenterology 50(54) Pages: 1774-1779
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Significant role of ceramide pathway in experimental gastric ulcer formation in rats. (2003)
  • Author(s): Uehara, K., Miura, S., Takeuchi, T., Taki, T., Nakashita, M., Adachi, M., Inamura, T., Ogawa, T., Akiba, Y., Suzuki, H., Nagata, H., Ishii, H.
  • Journal Title: J.Pharmacol.Exp.Ther. 305(1) Pages: 232-239
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Enhanced plasma ghrelin levels in rats with streptozotocin-induced diabetes. (2003)
  • Author(s): Masaoka, T., Suzuki, H., Hosoda, H., Ota, T., Minegishi, Y., Kangawa, K., Nagata, H., Ishii, H.
  • Journal Title: FEBS Lett. 541(1-3) Pages: 64-68
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Suppressed apoptosis in the inflamed gastric mucosa of H.pylori-colonized iNOS knockout mice. (2003)
  • Author(s): Miyazawa, M., Suzuki, H., Masaoka, T., Kai, A., Suematsu, M., Nagata, H., Miura, S., Ishii, H.
  • Journal Title: Free Radic.Biol.Med. 34 Pages: 1621-1630
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Rabeprazole treatment attenuated H.pylon-associated gastric mucosal lesion formation in Mongolian gerbils. (2003)
  • Author(s): Suzuki, H., Miyazawa, M., Nagahashi, S., Sato, M., Bessho, M., Nagata, H., Miura, S., Ishli, H.
  • Journal Title: J.Gastroenterol.Hepatol. 18(7) Pages: 787-795
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Helicobacter pylon-eradication therapy inhibits neutrophil-derived oxidants in the ulcerous mucosa in the human stomach : Relationship between ulcer stage and mucosal oxidant level. (2003)
  • Author(s): Suzuki, M., Suzuki, H., Kitahora, T., Nagahashi, S., Masaoka, M., Tanaka, S., Suzuki, K., Ishii, H.
  • Journal Title: Dig.Endosc. 15 Pages: 270-274
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Current consensus on the diagnosis and treatment of H.pylori-associated gastroduodenal disease. (2003)
  • Author(s): Suzuki, H., Masaoka, T., Nomura, S., Hoshino, Y., Kurabayashi, K., Minegishi, Y., Suzuki, M., Ishii, H.
  • Journal Title: Keio J.Med. 52(3) Pages: 163-173
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Perform and granzyme B of cytotoxic T lymphocyte mediate apoptosis irrespective of Helicobacter pylori infection possible act as a trigger of peptic ulcer formation. (2003)
  • Author(s): Ohara, T., Morishita, T., Suzuki, H., Masaoka, T., Ishil, H.
  • Journal Title: Hepatogastroenterol. 50(54) Pages: 1774-1779
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Enhanced plasma ghrelin levels in H.pylori-colonized, interleukin-1 receptor type 1-homozygous knockout (IL-1R14-) mice.
  • Author(s): Abiko, Y., Suzuki, H., Masaoka, T., Nomura, S., Kurabayashi, K., Hosoda, H., Kangawa, K., Hibi, T.
  • Journal Title: World J.Gastroenterol. (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Biomarkers in patients with gastric inflammation : a systematic review.
  • Author(s): Naito, Y., Ito, M., Watanabe, T., Suzuki, H.
  • Journal Title: Digestion (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Improvement of gastrointestinal quality of life (QOL) scores in cases of Helicobacter pylori-positive functional dyspepsia after successful eradication therapy.
  • Author(s): Suzuki, H., Masaoka, T., Sakal, G., Ishii, H., Hibi, T.
  • Journal Title: J.Gastroenterol.Hepatol. (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Investigation of the possibility of human-beta defensin 2 (hBD2) as a molecular marker of gastric mucosal inflammation.
  • Author(s): Ohara, T., Morishita, T., Suzuki, H., Hibi, T.
  • Journal Title: Hepatogastroenterol. (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Book] Microcirculation Annual 2004(Makishige Asano & Tetsuro Yamamoto) (2004)
  • Author(s): Han, J-Y., Suzuki, H.et al.
  • Publisher: Nihon-Igakukan, Tokyo
  • Description: 「研究成果報告書概要(和文)」より
• [Book] Microcirculation Annual 2004(Makishige Asano & Tetsuro Yamamoto) (2004)
  • Author(s): Ohara, T., Suzuki, H.et al.
  • Publisher: Nihon-Igakukan, Tokyo
  • Description: 「研究成果報告書概要(和文)」より
• [Book] Organ Microcirculation : Keio International Symposia for Life Sciences and Medicine(Ishii, H., Suematsu, M., Tanishita, K., Suzuki, H.) (2004)
  • Author(s): Suzuki, H. et al.
  • Publisher: Springer-Verlag Tokyo
  • Description: 「研究成果報告書概要(和文)」より
• [Book] Organ Microcirculation : Keio International Symposia for Life Sciences and Medicine(Ishii, H., Suematsu, M., Tanishita, K., Suzuki, H.) (2004)
  • Author(s): Ohara, T., Suzuki, H.et al.
  • Publisher: Springer-Verlag Tokyo
  • Description: 「研究成果報告書概要(和文)」より
• [Book] Organ Microcirculation : Keio International Symposia for Life Sciences and Medicine(Ishii, H., Suematsu, M., Tanishita, K., Suzuki, H.) (2004)
  • Author(s): Mizumori, N., Suzuki, H.et al.
  • Publisher: Springer-Verlag Tokyo
  • Description: 「研究成果報告書概要(和文)」より
• [Book] Organ Microcirculation : Keio International Symposia for Life Sciences and Medicine(Ishii, H., Suematsu, M., Tanishita, K., Suzuki, H.) (2004)
  • Author(s): Iwasaki, E., Suzuki, H.et al.
  • Publisher: Springer-Verlag Tokyo
  • Description: 「研究成果報告書概要(和文)」より
• [Book] Organ Microcirculation : Keio International Symposia for Life Sciences and Medicine(Ishii, H., Suematsu, M., Tanishita, K., Suzuki, H.) (2004)
  • Author(s): Han, J-Y., Suzuki, H.et al.
  • Publisher: Springer-Verlag Tokyo
  • Description: 「研究成果報告書概要(和文)」より
• [Book] Microcirculation annual 2004 (2004)
  • Author(s): Han, J.Y., Suzuki, H.et al.
• [Book] Microcirculation annual 2004 (2004)
  • Author(s): Ohara, T., Suzuki, H.et al.
• [Book] Organ Microcirculation : Keio International Symposia for Life Sciences and Medicine, Vol.13. (2004)
  • Author(s): Suzuki, H. et al.
• [Book] Organ Microcirculation : Keio International Symposia for Life Sciences and Medicine, Vol.13. (2004)
  • Author(s): Ohara, T., Suzuki, H.et al.
• [Book] Organ Microcirculation : Keio International Symposia for Life Sciences and Medicine, Vol.13. (2004)
  • Author(s): Mizumori, M., Suzuki, H.et al.
• [Book] Organ Microcirculation : Keio International Symposia for Life Sciences and Medicine, Vol.13. (2004)
  • Author(s): Iwasaki, E., Suzuki, H.et al.
• [Book] Organ Microcirculation : Keio International Symposia for Life Sciences and Medicine, Vol.13. (2004)
  • Author(s): Han, J.Y., Suzuki, H.et al.
• [Book] Microcirculation Annual 2003(Makishige Asano & Soichiro Miura) (2003)
  • Author(s): Han, J-Y., Suzuki, H.et al.
  • Publisher: Nihon-Igakukan, Tokyo
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 胃炎、萎縮性胃炎、または胃がんの診断用マーカー (2003)
  • Inventor(s): 鈴木 秀和, 石井 裕正, 寒川 賢治, 細田 洋司
  • Industrial Property Rights Holder: 慶應義塾
  • Filing Date: 2003-05-30
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 培養細胞の層に細胞欠損領域を作製する方法、その利用およびキット (2001)
  • Inventor(s): 鈴木 秀和, 石井 裕正
  • Industrial Property Rights Holder: 慶應義塾
  • Filing Date: 2001-10-26
  • Acquisition Date: 2005-05-16
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Masaoka, T., Suzuki, H.et al.: "Enhanced plasma ghrelin levels in streptozotocin-induced diabetic rats."FEBS Letters. 541(1-3). 64-68 (2003)
• [Publications] Miyazawa, M., Suzuki, H.et al.: "Suppressed apoptosis in the inflamed gastric mucosa of H.pylori-colinized iNOS knockout mice."Free Radical Biology and Medicine. 34(12). 1621-1630 (2003)
• [Publications] Suzuki, H.et al.: "Rabeprazole treatment attenuated H.pylori-associated gastric mucosal lesion formation in Mongolian gerbils."Journal of Gastroenterology and Hepatology. 18(7). 787-795 (2003)
• [Publications] Suzuki, M., Suzuki, H.et al.: "Helicobacter pylori-eradication therapy inhibits neutrophil-derived oxidants in the ulcerous mucosa in the human stomach : Relationship between ulcer stage and mucosal oxidant level."Digestive Endoscopy. 15(4). 270-275 (2003)
• [Publications] Suzuki, H.et al.: "Helicobacter pylori infection modifies gastric and plasma ghrelin dynamics in Mongolian gerbils."Gut. 53(2). 187-194 (2004)
• [Publications] Suzuki, H. et al.: "Lansoprazole promotes gastric mucosal cell proliferation and migration by activating P44/P42 mitogen-activated protein kinase."Wound Repair and Regeneration. 12(1). 93-99 (2004)
• [Publications] Han, J-Y., Suzuki, H.et al.: "Microcirculation Annual 2003 (Makishige Asano & Soichiro Miura)"Nihon-Igakukan, Tokyo. 39-40 (2003)