| Project/Area Number |
15590693
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Gastroenterology
|
|---|
| Research Institution | The Jikei University School of Medicine |
|---|
Principal Investigator |
KOIDO Shigeo The Jikei University School of Medicine, Lecturer, 医学部, 講師 (70266617)
|
|---|
| Project Period (FY) |
2003 – 2005
|
| Project Status |
Completed (Fiscal Year 2005)
|
| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2005: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2004: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2003: ¥1,800,000 (Direct Cost: ¥1,800,000)
|
|---|
| Keywords | dendritic cells / colorectal cancer / fusion cells / immunotherapy / CTL / tumor associated antigens / IFN-γ / tetramer / MHC / ワクチン / MUC1 / CEA |
|---|
| Research Abstract |
1.Human metastatic colorectal cancer cells expressing the CEA and/or MUC1 may represent a potential partner for the creation of DC/tumor fusion cells targeting induction of antigen-specific CTL responses.
2.The fusion of allogeneic colorectal carcinoma cell line and autologous dendritic cells could have potential applicability to the field of antitumor immunotherapy through the cross-priming against shared tumor antigens.
|
