A novel vaccines based on dendritic/tumor fusion cells
Project/Area Number |
15590693
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Gastroenterology
|
Research Institution | The Jikei University School of Medicine |
Principal Investigator |
KOIDO Shigeo The Jikei University School of Medicine, Lecturer, 医学部, 講師 (70266617)
|
Project Period (FY) |
2003 – 2005
|
Project Status |
Completed (Fiscal Year 2005)
|
Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2005: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2004: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2003: ¥1,800,000 (Direct Cost: ¥1,800,000)
|
Keywords | dendritic cells / colorectal cancer / fusion cells / immunotherapy / CTL / tumor associated antigens / IFN-γ / tetramer / MHC / ワクチン / MUC1 / CEA |
Research Abstract |
1.Human metastatic colorectal cancer cells expressing the CEA and/or MUC1 may represent a potential partner for the creation of DC/tumor fusion cells targeting induction of antigen-specific CTL responses. 2.The fusion of allogeneic colorectal carcinoma cell line and autologous dendritic cells could have potential applicability to the field of antitumor immunotherapy through the cross-priming against shared tumor antigens.
|
Report
(4 results)
Research Products
(23 results)
-
-
[Journal Article] Dendritic cells fused with allogeneic colorectal cancer cell line present multiple colorectal cancer-specific antigens and induce antitumor immunity against autologous tumor cells.2005
Author(s)
Koido S, Hara E, Homma S Torii A, Toyama Y, Kawahara H, Watanabe M, Yanaga K, Fujise K, Tajiri H, Gong J, Toda G.
-
Journal Title
Clin Cancer Res. 11・21
Pages: 7891-7900
Description
「研究成果報告書概要(和文)」より
Related Report
-
-
[Journal Article] Induction of antigen-specific CD4- and CD8-mediated T-cell responses by fusions of autologous dendritic cells and metastatic colorectal cancer cells.2005
Author(s)
Koido S, Hara E, Torii A, Homma S, Toyama Y, Kawahara E, Ogawa M, Watanabe M, Yanaga K, Fujise K, Gong J, Toda G.
-
Journal Title
Int J Cancer. 117・4
Pages: 587-595
Description
「研究成果報告書概要(和文)」より
Related Report
-
-
[Journal Article] Dendritic cells fused with allogeneic colorectal cancer cell line present multiple colorectal cancer-specific antigens and induce antitumor immunity against autologous tumor cells.2005
Author(s)
Koido S, Hara E, Homma S, Torii A, Toyama Y, Kawahara H, Watanabe M, Yanaga K, Fujise K, Tajiri H, Gong J, Toda G.
-
Journal Title
Clin Cancer Res. 11
Pages: 7891-7900
Description
「研究成果報告書概要(欧文)」より
Related Report
-
-
[Journal Article] Induction of antigen-specific CD4- and CD8-mediated T-cell responses by fusions of autologous dendritic cells and metastatic colorectal cancer cells.2005
Author(s)
Koido S, Hara E, Torii A, Homma S, Toyama Y, Kawahara H, Ogawa M, Watanabe M, Yanaga K, Fujise K, Gong J, Toda G.
-
Journal Title
Int J Cancer. 117
Pages: 587-589
Description
「研究成果報告書概要(欧文)」より
Related Report
-
-
[Journal Article] Dendritic cells fused with allogeneic colorectal cancer cell line present multiple colorectal cancer-specific antigens and induce antitumor immunity against autologous tumor cells.2005
Author(s)
Koido S, Hara E, Homma S, Torii A, Toyama Y, Kawahara H, Watanabe M, Yanaga K, Fujise K, Tajiri H, Gong J, Toda G.
-
Journal Title
Clin Cancer Res. 11・21
Pages: 7891-7900
Related Report
-
-
[Journal Article] Induction of antigen-specific CD4- and CD8-mediated T-cell responses by fusions of autologous dendritic cells and metastatic colorectal cancer cells.2005
Author(s)
Koido S, Hara E, Torii A, Homma S, Toyama Y, Kawahara H, Ogawa M, Watanabe M, Yanaga K, Fujise K, Gong J, Toda G.
-
Journal Title
Int J Cancer. 117・4
Pages: 587-595
Related Report
-
-
-
-
-
-
[Journal Article] Induction of anti-leukemic cytotoxic T lymphocytes by fusion of patient-derived dendritic cells with autologous myeloblasts.2004
Author(s)
Gong J, Koido S, Kato Y, Tanaka Y, Chen D, Jonas A, Galinsky I, DeAngelo D, Avigan D, Kufe D, Stone R.
-
Journal Title
Leuk Res. Dec;28
Pages: 1303-1312
Description
「研究成果報告書概要(欧文)」より
Related Report
-
-
-
-
-