| Project/Area Number |
15590726
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MATSUMOTO Akihiro The University of Tokyo, Faculty of Medicine, Assistant, 医学部附属病院, 助手 (70323574)
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| Co-Investigator(Kenkyū-buntansha) |
TERAUCHI Yasuo Yokohama City University, Faculty of Medicine, Professor, 医学部附属病院, 教授 (40359609)
NAKAJIMA Toshiaki The University of Tokyo, Faculty of Medicine, visiting Assistant Professor, 医学部附属病院, 寄附講座教員 (50227790)
TAKENAKA Katsu The University of Tokyo, Faculty of Medicine, Lecturer, 医学部附属病院, 講師 (20188204)
KADOWAKI Takashi The University of Tokyo, Faculty of Medicine, Professor, 医学部附属病院, 教授 (30185889)
HIRATA Yasunobu The University of Tokyo, Faculty of Medicine, Assistant Professor, 医学部附属病院, 助教授 (70167609)
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| Project Period (FY) |
2003 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2004: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2003: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Keywords | adiponectin / coronary artery disease / diabetes mellitus / metabolic taclors / atherosclerosis / exercise training / exercise capacity / nitric oxide / 高脂血症 / 肥満 |
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| Research Abstract |
Adiponectin plays an important role in the metabolic syndrome and insulin sensitivity. To investigate its clinical roles, the relationships of plasma adiponectin levels with blood sugar and exercise capacity were studied in patients with coronary artery diseases, who have diabetes mellitus, hypertension, and/or obesity. The effects of cardiac rehabilitation on plasma adiponectin, exercise capacity, and exhaled nitric oxide output were also evaluated. The plasma adiponectin level was low (8.1±5.9 [mean±SD] μg/ml) in these patients. Their body mass index was 25.4±3.1. They had higher levels of fasting blood sugar (126±39 mg/dl) and HbAlc (5.9±1.2 %). Peak oxygen uptake was moderately decreased (68±12 % of predicted normal values). Cardiac rehabilitation increased plasma adiponectin level from 14.3±2.0 to 16.1±2.1 μg/ml (p<0.05) in the training group, but not in the non-training group. Cardiac rehabilitation increased peak oxygen uptake and anaerobic threshold in the training group, but not in the non-training group. Cardiac rehabilitation also increased exhaled nitric oxide output at peak exercise in the training group, but not in the non-training group. Plasma adiponectin level was decreased in patients with coronary artery diseases, and this was due to the high existence of obesity and diabetes mellitus in these patients. Exercise capacity such as peak oxygen uptake and anaerobic threshold was decreased in these subjects, and mall amount of exercise in daily activities plays an important role in the lower level of plasma adiponectin. Cardiac rehabilitation increased plasma adiponectin level with the simultaneous increase in exercise capacity. Cardiac rehabilitation also increased exhaled nitric oxide output during exercise, suggesting that it improved endothelium function. The beneficial effect of exercise training on plasma adiponectin level may play important role in the improvement of insulin resistance in these patients.
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