| Project/Area Number |
15590731
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | GIFU UNIVERSITY |
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Principal Investigator |
FUJIWARA Hisayoshi Gifu University, Graduate School of Medicine, Professor, 大学院・医学研究科, 助手 (20334930)
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| Co-Investigator(Kenkyū-buntansha) |
藤原 久義 岐阜大学, 大学院・医学研究科, 教授 (80115930)
FUJITA Hiroshi Gifu University, Graduate School of Medicine, Professor, 大学院・医学研究科, 教授 (10124033)
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| Project Period (FY) |
2003 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2004: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2003: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | ultrasound / tissue / arterial plaque / atherosclerosis / 画像 / 三次元 |
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| Research Abstract |
Conventional IVUS images and IB signals were acquired using a commercially available IVUS imaging system to characterize the coronary arterial tissue using a 40 MHz IVUS catheter. We used an analog-digital converter, which enabled acquisition, storage and retrieval of signals that were digitized at 2 GHz with 8-bit resolution. Off-line analyses of the acquired RF signals were performed on previously stored data from the built-in memory using software that we described in an earlier report. Color-coded construction was performed by computer software.
2D IB-IVUS showed that angiographically normal coronary lesions have various types of plaque. Tissue characteristics of angiographically normal coronary lesions appear to be significantly influenced by both diabetes mellitus and hypertension. This information might be useful for protection against the progression of coronary atherosclerosis to more advanced stages.
We developed a 3D IB-IVUS system. 3D IB-IVUS analyses were performed in 52 patients with angina pectoris and hyperlipidemia before and after statin therapy for 6 months. Significant increase of relative fibrous volume and a reduction of relative lipid volume were observed after statin therapy. The 3D IB-IVUS images can visualize lipid pools, fibrous lesions, mixed lesions and calcification in the plaque of human coronary arteries in vivo. 3D IB-IVUS offers the potential to improve the tissue characterization of plaques compared to conventional IVUS for the assessment of the history of coronary atherosclerosis.
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