Hypoxic stress and atherosclerosis in patients with sleep apnea-hypopnea syndrome
| Project/Area Number |
15590821
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Nara Medical University |
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Principal Investigator |
KIMURA Hiroshi Nara Medical University, second Dept of Medicine, Professor, 医学部, 教授 (20195374)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIKAWA Masanori Nara Medical University, second Dept of Medicine, Assistant Professor, 医学部, 講師 (80271203)
FUKUOKA Atsuhiko Nara Medical University, second Dept of Medicine, Assistant, 医学部, 助手 (10336852)
TAMAKI Shinji Nara Medical University, second Dept of Medicine, Assistant, 医学部, 助手 (30347546)
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| Project Period (FY) |
2003 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2004: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2003: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | sleep / apnea / atherosclerosis / hypoxia / cytokines / adiponectin / continuous positive airway pressure / 粥状硬化症 / 睡眠 / 細胞外マトリックス |
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| Research Abstract |
Obstructive sleep apnea-hypopnea syndrome(OSAHS) is characterized by recurrent episodes of oxygen desaturation during sleep. In addition, recent studies have shown that OSAHS may be one of the important independent risk factors of cardiovascular diseases.
The aim of the present study was (1)to clarify the effect of hypoxic stress on the production of TNF-α and MCP-1 by peripheral blood monocytes, and (2)to investigate the impact of hypoxic stress on plasma adiponectin(ADPN) in patients with OSAHS. We also examined the long-term or the short-term effects of nasal continuous positive airway pressure(nCPAP) on the production of TNF-α and MCP-1, and ADPN.
Summary of results ; (1)The elevated production of TNF-α and MCP-1 by monocytes was associated with OSAHS-induced hypoxic stress. This phenomenon may contribute to the development of atherosclerosis in OSAHS. Furthermore, it was suggested that nCPAP therapy for 3 months may be beneficial to the prevention of atherosclerosis in OSAHS. (2)Both reduced ADPN and elevated TNF-α in plasma are associated with OSAS-induced hypoxic stress. The suppressed level of plasma ADPN in OSAHS was not fully recovered by the short-term nCPAP therapy for 1 day.
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Report
(3 results)
Research Products
(4 results)
