| Project/Area Number |
15590901
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Kagoshima University |
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Principal Investigator |
HASHIGUCHI Teruto Kagoshima University, Graduate School of Medical and Dental Sciences, Associate Professor, 大学院・医歯学総合研究科, 助教授 (70250917)
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| Co-Investigator(Kenkyū-buntansha) |
MARUYAMA Ikuro Kagoshima University, Graduate School of Medical and Dental Sciences, Professor, 大学院・医歯学総合研究科, 教授 (20082282)
ARIMURA Kimiyoshi Kagoshima University, Graduate School of Medical and Dental Sciences, Associate Professor, 大学院・医歯学総合研究科, 助教授 (20159510)
ABEYAMA Kazuhiro Kagoshima University, Graduate School of Medical and Dental Sciences, Visiting Associate Professor, 大学院・医歯学総合研究科, 客員助教授 (30284897)
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| Project Period (FY) |
2003 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2004: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2003: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | Crow-Fukase syndrome / POEMS syndrome / vascular endothelial growth factor / VEGF / platelet / megakaryocyte / embryonic lethality / B cell / platelet / Crow-Fukase syndrome / POEMS syndrome / transgenic mouse / megakaryocyte / atherosclerosis / diabetic retinopathy |
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| Research Abstract |
Vascular endothelial growth factor(VEGF) is an endothelial cell-specific potent mitogen that induces angiogenesis and microvascular hyperpermeability. Megakaryocytes and platelets are a very rich source of circulating VEGF. Platelet VEGF is bioactive as a direct angiogenic growth factor, and may play a very important role in wound healing and atherosclerosis (J Thromb Haemost.2003,(12):2589-93). In Crow-Fukase(POEMS) syndrome, platelet VEGF markedly elevated. We reported a case diagnosed as Crow-Fukase syndrome, in which the serial platelet count and VEGF concentration were determined before and during the state of disseminated intravascular coagulation(DIC). The serum VEGF concentration was noted to be gradually decreased prior to DIC, after which it abruptly decreased with a corresponding drop in platelet count upon the onset of DIC. The physiological effects of VEGF are viewed as one of the causative factors in DIC and its abrupt and excessive release may have caused the exacerbation of the patient's clinical symptoms(Tokashiki T et al. Intern Med. 2003,42(12):1240-3). The factors which stimulate the over-production of platelet VEGF in Crow-Fukase syndrome is still unknown. To investigate this unknown factor, we are planning to facilitate the proteomics technology in the next project.
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