| Project/Area Number |
15590904
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | JICHI MEDICAL SCHOOL |
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Principal Investigator |
MURAMATSU Shin-ichi Jichi Medical School, Medicine, Associate Professor, 医学部, 助教授 (10239543)
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| Project Period (FY) |
2003 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2004: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2003: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | basal ganglia / dopamine / Parkinson's disease / gene therapy / cognitive function / MPTP / cynomolgus monkey / adeno-associated virus / 線条体 / 認知障害 |
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| Research Abstract |
To elucidate the cognitive function specific to the striatum, groups of cynomolgus monkeys with toxin-induced Parkinsonian motor symptoms were compared with normal controls on a computerized battery of tests designed to investigate conception set shift. The tests assess the ability to shift cognitive set modeled after the Wisconsin Card Sorting Test that is sensitive to impairments in patients with Parkinson's disease(PD). The monkeys with chronic treatment of 1-metil-4-phenil-1-2-3-6-tetrahydropyridine (MPTP) showed similar difficulty with the patients with PD in the set-shift task. Positron emission tomography showed that impairment of dopaminergic function was confined to the nigro-striatal system in these monkeys and that recombinant adeno-associated viral vector (AAV)-mediated selective restoration of 1-dopa uptake in the treated putamen. The combination of computerized battery of tests and gene transfer using AAV vectors is a powerful tool to study higher cognitive function of the basal ganglia.
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