• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Role of SLC and ELC chemokines in the development of experimental allergic encephalomyelitis as an animal model of multiple sclerosis.

Research Project

Project/Area Number 15590911
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurology
Research InstitutionToho University

Principal Investigator

KAKIUCHI Terutaka  Toho University, Sch.Med., Dept.Immunol., Professor, 医学部, 教授 (40126024)

Co-Investigator(Kenkyū-buntansha) IWASAKI Yasuo  Toho University, Sch.Med., Dept.Int.Med.(Omori), Professor, 医学部, 教授 (30130347)
中野 英樹  東邦大学, 医学部, 講師 (30266928)
Project Period (FY) 2003 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2004: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 2003: ¥1,900,000 (Direct Cost: ¥1,900,000)
Keywordsplt mouse / CCL21 chemokine / CCL19 chemokine / Experimental Allergic Encephalomyelitis / T cell / Regulation of T cell response / Multiple Sclerosis / SLC(CCl21)ケモカイン / ELC(CCL19)ケモカイン
Research Abstract

Experimental allergic encephalomyelitis(EAE) is an animal model for multiple sclerosis. C57BL/6 mouse immunized subcutaneously with myelin oligodendrocyte glycoprotein(MOG) 35-55 peptide(MOG35-55 peptide) in CFA developed EAE. However, C57BL/6-plt/plt mouse did not develop EAE, when similarly treated. plt mouse has a defect in the expression of CCL19/CCL21. Thus, it is possible that these chemokines are involved in the development of EAE. There were two possibilities ; one was the migration failure of pathogenic T cells into CNS, the other was that pathogenic T cells were not generated in the plt mouse. To differentiate these possibilities, T cells from C57BL/6 wild type mice immunized with MOG35-55 peptide in CFA were intravenously transferred into plt mice, which resulted in the development of EAE in plt mice. When draining lymph node cells from these mice intravenously immunized with MOG peptide in CFA, were stimulated in vitro with the peptide, T cells from plt mice produced much more IL-4 than those from wild type mice, whereas IFN-γ was inversely produced. These results, although the experiments were still preliminary, suggested that CCL19/CCL21 are involved in the generation of pathogenic Th1 cells for EAE induction. The mechanisms for the involvement of these chemokines are now under the investigation.

Report

(3 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • Research Products

    (21 results)

All 2004 2003 Other

All Journal Article (16 results) Publications (5 results)

  • [Journal Article] Role of CCL21 in Recruitment of T Precursor Cells to Fetal Thymus.2004

    • Author(s)
      Liu C, Ueno T, Kuse S, Saito F, Nitta T, Piali L, Nakano H, Kakiuchi T, Lipp M, Hollander GA, Takahama Y.
    • Journal Title

      Blood 105・1

      Pages: 31-39

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Localization of marginal zone macrophages is regulated by C-C chemokine ligands 21/19.2004

    • Author(s)
      Ato M, Nakano H, Kakiuchi T, Kaye PM.
    • Journal Title

      J.Immunol. 173・8

      Pages: 4815-4820

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] CCR7 signals are essential for cortex-medulla migration of developing thymocytes.2004

    • Author(s)
      Ueno T, Saito F, Gray DH, Kuse S, Hieshima K, Nakano H, Kakiuchi T, Lipp M, Boyd RL, Takahama Y.
    • Journal Title

      J.Exp.Med. 200・4

      Pages: 493-505

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Irradiation up-regulates CD80 expression through two different mechanisms in spleen B cells, B lymphoma cells, and dendritic cells.2004

    • Author(s)
      Torihata H, Ishikawa F, Okada Y, Tanaka Y, Uchida T, Suguro T, Kakiuchi T.
    • Journal Title

      Immunology 112・2

      Pages: 219-227

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Role of CCL21 in Recruitment of T Precursor Cells to Fetal Thymus.2004

    • Author(s)
      Liu C, Ueno T, Kuse S, Saito F, Nitta T, Piali L, Nakano H, Kakiuchi T, Lipp M, Hollander GA, Takahama Y.
    • Journal Title

      Blood 105(1)

      Pages: 31-39

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Localization of marginal zone macrophages is regulated by C-C chemokine ligands 21/19.2004

    • Author(s)
      Ato M, Nakano H, Kakiuchi T, Kaye PM.
    • Journal Title

      J.Immunol. 173(8)

      Pages: 4815-4820

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] CCR7 signals are essential for cortex-medulla migration of developing thymocytes.2004

    • Author(s)
      Ueno T, Saito F, Gray DH, Kuse S, Hieshima K, Nakano H, Kakiuchi T, Lipp M, Boyd RL, Takahama Y.
    • Journal Title

      J.Exp.Med. 200(4)

      Pages: 493-505

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Irradiation up-regulates CD80 expression through two different mechanisms in spleen B cells, B lymphoma cells, and dendritic cells.2004

    • Author(s)
      Torihata H, Ishikawa F, Okada Y, Tanaka Y, Uchida T, Suguro T, Kakiuchi T.
    • Journal Title

      Immunology 112(2)

      Pages: 219-227

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Induction of antigen-dependent interleukin-12 production by negatively charged liposomes encapsulating antigens.2004

    • Author(s)
      Yotsumoto S, Aramaki Y, Kakiuchi T, Tsuchiya S.
    • Journal Title

      Vaccine 22・25-26

      Pages: 3503-3509

    • Related Report
      2004 Annual Research Report
  • [Journal Article] CCR7 signals are essential for cortex-medulla migration of developing thymocytes.2004

    • Author(s)
      Ueno T, Saito F, Gray DH, Kuse S, Hieshima K, Nakano H, Kakiuchi T, Lipp M, Boyd RL, Takahama Y.
    • Journal Title

      J Exp Med. 200・4

      Pages: 493-505

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Irradiation up-regulates CD80 expression through two different mechanisms in spleen B cells, B lymphoma cells, and dendritic cells.2004

    • Author(s)
      Torihata H, Ishikawa F, Okada Y, Tanaka Y, Uchida T, Suguro T, Kakiuchi T.
    • Journal Title

      Immunology. 112・2

      Pages: 219-227

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Role of macrophages a mouse model of postoperative MRSA enteritis.2004

    • Author(s)
      Tanaka H, Miyazaki S, Sumiyama Y, Kakiuchi T.
    • Journal Title

      J Surg Res. 118・2

      Pages: 114-121

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Selective enhancement of B cell antigen receptor-mediated antigen presentation by treatment with transforming growth factor-beta.2003

    • Author(s)
      Arai C, Ichijo T, Tanaka Y, Okada Y, Umeda M, Uchida T, Kiniwa M, Kakiuchi T.
    • Journal Title

      Eur.J.Immunol. 33・7

      Pages: 1806-1815

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Distinct antigen trafficking from skin in the steady and active states.2003

    • Author(s)
      Yoshino M, Yamazaki H, Nakano H, Kakiuchi T, Ryoke K, Kunisada T, Hayashi S.
    • Journal Title

      Int.Immunol. 15・6

      Pages: 773-779

    • NAID

      10014341739

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Selective enhancement of B cell antigen receptor-mediated antigen presentation by treatment with transforming growth factor-beta.2003

    • Author(s)
      Arai C, Ichijo T, Tanaka Y, Okada Y, Umeda M, Uchida T, Kiniwa M, Kakiuchi T.
    • Journal Title

      Eur.J.Immunol. 33(7)

      Pages: 1806-1815

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Distinct antigen trafficking from skin in the steady and active states.2003

    • Author(s)
      Yoshino M, Yamazaki H, Nakano H, Kakiuchi T, Ryoke K, Kunisada T, Hayashi S.
    • Journal Title

      Int.Immunol. 15(6)

      Pages: 773-779

    • NAID

      10014341739

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Publications] Arai C, Ichijo T, Tanaka Y, Okada Y, Umeda M, Uchida T, Kiniwa M, Kakiuchi T.: "Selective enhancement of B cell antigen receptor-mediated antigen presentation by treatment with transforming growth factor-beta"Eur J Immunol. 33(7). 1806-1815 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yoshino M, Yamazaki H, Nakano H, Kakiuchi T, Ryoke K, Kunisada T, Hayashi S: "Distinct antigen trafficking from skin in the steady and active states"Int Immunol. 15(6). 773-779 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Torihata H, Ishikawa F, Okada Y, Tanaka Y, Uchida T, Suguro T, Kakiuchi T: "Irradiation up-regulates CD80 expression through two different mechanisms in spleen B cells, B lymphoma cells, and dendritic cells"Immunology. In press.

    • Related Report
      2003 Annual Research Report
  • [Publications] Tanaka H, Miyazaki S, Sumiyama Y, Kakiuchi T: "Role of macrophages in a mouse model of postoperative MRSA enteritis"J Surg Res.. In press.

    • Related Report
      2003 Annual Research Report
  • [Publications] Shimizu E, Koike J, Wakao H, Seino K, Koseki H, Kakiuchi T, Nakayama T, Taniguchi M: "Role of a NK receptor, KLRE-1, in bone marrow allograft rejection : analysis with KLRE-1 deficient mice"Blood. In press.

    • Related Report
      2003 Annual Research Report

URL: 

Published: 2003-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi