| Project/Area Number |
15590913
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Neurology
|
|---|
| Research Institution | Nippon Medical School |
|---|
Principal Investigator |
YAMAZAKI Mineo Nippon Medical School, teaching fellow, 医学部, 助手 (10277577)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MURAYAMA Shigeo Tokyo Metropolitan Institute of Gerontology, Team Leader, 老化臨床神経科学研究グループ, 参事研究員 (50183653)
|
|---|
| Project Period (FY) |
2003 – 2004
|
| Project Status |
Completed (Fiscal Year 2004)
|
| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2004: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2003: ¥2,300,000 (Direct Cost: ¥2,300,000)
|
|---|
| Keywords | corticobasal degeneration / progressive supranuclear palsy / tauopathy / 皮質基底核変性病 / タウオパター |
|---|
| Research Abstract |
Progressive supranuclear palsy(PSP) is a neurodegenerative disorder that is characterized by parkinsonism and dementia. However, the aged patients with PSP did not always show both parkinsonism and dementia. We investigated retrospectively the clinical data of 51 autopsy-proven cases with PSP to clarify their clinicopathological multiplicity. Among 51 patients with PSP,21 cases showed typical neurological symptoms compatible to PSP, but 20 cases did not show apparent parkinsonism and could go about their daily life without any problem. Among 20 PSP patients lacking obvious parkinsonism,14 cases presented only dementia (mean age:85.5±7.5) and six cases did not show obvious parkinsonism nor dementia (mean age:90.5±9.8). The mean age of PSP cases without parkinsonism was significantly higher than that of PSP cases with parkinsonism. But there is no significant difference in the brain weight of PSP patients between those with and without parkinsonism. Only two cases with PSP showed cerebellar ataxia, but the distribution and severity of lesions were same as those of other PSP cases. Parts pf the aged PSP patients, though a few in number, showed only dementia.
|
