| Project/Area Number |
15590918
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | University of Occupational and Environmental Health |
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Principal Investigator |
UOZUMI Takenori University of Occupational and Environmental Health, School of Medicine, Assist. Prof, 医学部, 助教授 (00160226)
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| Project Period (FY) |
2003 – 2004
|
| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 2004: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2003: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | area44 / magnetic stimlation / motor area / motoe evoked potentioal / 運動機能 / 44野 |
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| Research Abstract |
Background : In order to elucidate whether area 44 of human frontal cortex is essential for the organization of voluntary hand movements or not, we examined effects of single transcranial magnetic stimulation (TMS) of human area 44 on voluntary hand movement and EMG activities in hand muscles. Method :
Results : Single TMS over area 44 could easily interrupt target-oriented hand movements. Human area 44 has a facilitatory and inhibitory effects over both tonic and phasic finger movements, not only action imitation. We show that single TMS of area 44 produces motor evoked potential (MEP) from hand muscles. Conclusion: These results are the first direct evidence to demonstrate that human area 44 is strongly involved in voluntary hand movements and has direct fast-conducting corticospinal projections.
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