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Mechanism of Vascular Calcification : Role of Calcium and Phosphate Metabolism

Research Project

Project/Area Number 15590954
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Metabolomics
Research InstitutionOsaka City University

Principal Investigator

JONO Shuichi  Osaka City University, Graduate School of Medicine, Department of Metabolism, Endocrinology and Molecular Medicine, Research Associate, 大学院・医学研究科, 助手 (60336790)

Co-Investigator(Kenkyū-buntansha) SHIOI Atsushi  Osaka City University, Graduate School of Medicine, Department of Cardiovascular Medicine, Lecturer, 大学院・医学研究科, 講師 (90260801)
Project Period (FY) 2003 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2004: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2003: ¥2,000,000 (Direct Cost: ¥2,000,000)
KeywordsVascular calcification / Atherosclerosis / Osteoprotegerin / Matrix Gla protein / Phosphate transporter / Bone associated protein / 動脈硬化 / TRAIL / Matrix Gla Protein
Research Abstract

Vascular calcification is often encountered in the development of atherosclerotic intimal lesions. In chronic renal failure patients, vascular calcification contributes to both the morbidity and mortality. Although the molecular mechanisms regulating vascular calcification remain obscure, recent studies suggest that vascular calcification may be an actively regulated process in which vascular cells may acquire osteoblast-like functions. Several clinical studies indicate that a high serum phosphate level is highly correlated with the extent of vascular calcification and vascular disease. In vitro studies demonstrated that inorganic phosphate regulates the expression of bone matrix proteins, and that calcification is regulated by inorganic phosphate through a sodium dependent phosphate transport system. These findings suggest that inorganic phosphate may play an important role in the development of vascular calcification.

Report

(3 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • Research Products

    (18 results)

All 2005 2004 Other

All Journal Article (16 results) Book (1 results) Publications (1 results)

  • [Journal Article] Hyperphosphatemia and vascular calcification in end-stage renal disease.2005

    • Author(s)
      Nishizawa Y, Jono S, Ishimura E, Shioi A.
    • Journal Title

      J Ren Nutr 15

      Pages: 178-182

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Increased levels of serum osteoprotegerin in hypothyroid patients and its normalization with restoration of normal thyroid function.2005

    • Author(s)
      Nagasaki T, Inaba M, Jono S, et al.
    • Journal Title

      Eur J Endocrinol 152

      Pages: 347-353

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Cross-sectional association of serum phosphate with carotid intimamedial thickness in hemodialysis patients.2005

    • Author(s)
      Ishimura E, Taniwaki H, Tabata T, Tsujimoto Y, Jono S, et al.
    • Journal Title

      Am J Kidney Dis 45

      Pages: 859-865

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Hyperphosphatemia and vascular calcification in end-stage renal disease.2005

    • Author(s)
      Nishizawa Y, et al.
    • Journal Title

      J Ren Nutr. 15

      Pages: 178-182

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Cross-sectional association of serum phosphate with carotid intima-medial thickness in hemodialysis patients.2005

    • Author(s)
      Ishimura E, et al.
    • Journal Title

      Am J Kidney Dis. 45

      Pages: 859-865

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Increased levels of serum osteoprotegerin in hypothyroid patients and its normalization with restoration of normal thyroid function.2005

    • Author(s)
      Nagasaki T, et al.
    • Journal Title

      Eur J Endocrinol. 152

      Pages: 347-353

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The clinical significance of serum osteocalcin and N-terminal propeptide of type I collagen in predialysis patients with chronic renal failure.2005

    • Author(s)
      Tsuchida T, et al.
    • Journal Title

      Osteoporos Int. 16

      Pages: 172-179

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Hyperphosphatemia and vascular calcification in end-stage renal disease.2005

    • Author(s)
      Nishizawa Y, Jono S, Ishimura E, et al.
    • Journal Title

      J Ren Nutr 15

      Pages: 178-182

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Matrix Gla Protein is associated with coronary artery calcification as assessed by electron-beam computed tomography2004

    • Author(s)
      Jono S, Ikari Y, Shioi A, et al.
    • Journal Title

      Thrombosis Haemostasis 91

      Pages: 790-794

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Statins inhibit in vitro calcification of human vascular smooth muscle cells induced by inflammatory mediators2004

    • Author(s)
      Kizu A, Shioi A, Jono S, et al.
    • Journal Title

      J Cell Biochem 93

      Pages: 1011-1019

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] C-reactive protein is a significant predictor of vascular calcification of both aorta and hand arteries.2004

    • Author(s)
      Ishimura E, Okuno S, Kitatani K, Jono S, et al.
    • Journal Title

      Semin Nephrol 24

      Pages: 408-412

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Matrix Gla protein is associated with coronary calcification as assessed by electron-beam computed tomography.2004

    • Author(s)
      Jono S, et al.
    • Journal Title

      Thromb Haemost. 91

      Pages: 790-794

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Statins inhibit in vitro calcification of human vascular smooth muscle cells induced by inflammatory mediators.2004

    • Author(s)
      Kizu A, et al.
    • Journal Title

      J Cell Biochem. 93

      Pages: 1011-1019

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] C-reactive protein is a significant predictor of vascular calcification of both aorta and hand arteries.2004

    • Author(s)
      Ishimura E, et al.
    • Journal Title

      Semin Nephrol. 24

      Pages: 408-412

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Mechanism of vascular calcification2004

    • Author(s)
      Kizu A, Jono S
    • Journal Title

      Clin Calcium 14

      Pages: 92-96

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Risk factors of atherosclerosis in end-stage renal disease patients2004

    • Author(s)
      Jono S
    • Journal Title

      Clin Calcium 14

      Pages: 21-26

    • Related Report
      2004 Annual Research Report
  • [Book] 腎不全とリン2004

    • Author(s)
      城野修一
    • Total Pages
      197
    • Publisher
      日本メデイカルセンター
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Publications] S.Jono, Y.Ikari, A.Shioi, et al.: "Matrix Gla protein is associated with coronary artery calcification as assessed by electron-beam computed tomography"Thrombosis Haemostasis. 91(in press). (2004)

    • Related Report
      2003 Annual Research Report

URL: 

Published: 2003-04-01   Modified: 2016-04-21  

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