| Project/Area Number |
15590954
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Osaka City University |
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Principal Investigator |
JONO Shuichi Osaka City University, Graduate School of Medicine, Department of Metabolism, Endocrinology and Molecular Medicine, Research Associate, 大学院・医学研究科, 助手 (60336790)
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| Co-Investigator(Kenkyū-buntansha) |
SHIOI Atsushi Osaka City University, Graduate School of Medicine, Department of Cardiovascular Medicine, Lecturer, 大学院・医学研究科, 講師 (90260801)
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| Project Period (FY) |
2003 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2004: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2003: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | Vascular calcification / Atherosclerosis / Osteoprotegerin / Matrix Gla protein / Phosphate transporter / Bone associated protein / 動脈硬化 / TRAIL / Matrix Gla Protein |
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| Research Abstract |
Vascular calcification is often encountered in the development of atherosclerotic intimal lesions. In chronic renal failure patients, vascular calcification contributes to both the morbidity and mortality. Although the molecular mechanisms regulating vascular calcification remain obscure, recent studies suggest that vascular calcification may be an actively regulated process in which vascular cells may acquire osteoblast-like functions. Several clinical studies indicate that a high serum phosphate level is highly correlated with the extent of vascular calcification and vascular disease. In vitro studies demonstrated that inorganic phosphate regulates the expression of bone matrix proteins, and that calcification is regulated by inorganic phosphate through a sodium dependent phosphate transport system. These findings suggest that inorganic phosphate may play an important role in the development of vascular calcification.
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