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RELATIONSHIP BETWEEN NEUROPEPTIDES AND NITRIC OXIDE IN REGULATING GROWTH HORMONE SECRETION

Research Project

Project/Area Number 15590979
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Endocrinology
Research InstitutionSHIMANE UNIVERSITY (2004)
Shimane Medical University (2003)

Principal Investigator

KATO Yuzuru  SHIMANE UNIVERSITY, SCHOOL OF MEDICINE, PROFESSOR, 医学部, 教授 (90030965)

Co-Investigator(Kenkyū-buntansha) MURAKAMI Yoshio  SHIMANE UNIVERSITY, SCHOOL OF MEDICINE, ASSISTANT PROFESSOR, 医学部, 助教授 (10252909)
SOHMIYA Motoi  SHIMANE UNIVERSITY, SCHOOL OF MEDICINE, INSTRUCTOR, 医学部, 講師 (50243431)
YAMANE Yuko  SHIMANE UNIVERSITY, SCHOOL OF MEDICINE, ASSISTANT, 医学部, 助手 (20335566)
YAMAMOTO Masahiro  SHIMANE UNIVERSITY, SCHOOL OF MEDICINE, ASSISTANT, 医学部, 助手 (50346392)
越村 邦夫  島根大学, 医学部, 講師 (90192575)
Project Period (FY) 2003 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2004: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2003: ¥2,100,000 (Direct Cost: ¥2,100,000)
KeywordsGROWTH HORMONE / NEUROPEPTIDES / NITRIC OXIDE / PITUITARY / HYPOTHALAMUS / INSULIN-LIKE GROWTH FACTOR / CALCIUM CHANNNEL / REGULATION OF SECRETION
Research Abstract

Nitric oxide(NO) is a new factor to regulate a number of cell functions. However, a role of NO in the endocrine system remains to be elucidated. We previously reported that endogenous NO plays a role in regulating growth hormone(GH) secretion in GH_3 cells as autocrine and paracrine functions. We also found that NOS, a specific synthetase of NO, exists in pituitary GH producing cells. In normal subjects, intravenous infusion of TRH rather inhibited GH secretion although the mechanisms remain to be clarified. TRH may stimulate somatostatin secretion from the hypothalamus, which in turn inhibits GH secretion from the pituitary. Otherwise, TRH may stimulate NO release from surrounding gonadotroph cells in the pituitary, which inhibites GH secretion from GH produsing cells. On the other hand, GH binds to the vasucular endothels in which GH could modify the production of NO. NO also has an important role in the memory function of the hypocampus, in which NO synthesis is regulated by a number of neuropeptides including erythropoietin (EPO) and insulin-like growth factor (IGF-I).
In the present study, we clearly elucidated the following mechanisms in which 1)TRH stimulated NO production in GH_3 cells, 2)NO production in the pituitary cells in normal rats, 3)GH stimulated NO production in human endothelial cells, 4)the distribution of NOS and stimulation of NO production by EPO and IGF-I in rat hypocampus. These findings strongly indicate that NO plays an important role in regulating GH secretion, GH action and the memory function in the central nervous system.

Report

(3 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • Research Products

    (27 results)

All 2005 2004 2003 Other

All Journal Article (21 results) Publications (6 results)

  • [Journal Article] Effect of recombinant human GH on circulating granulocyte clony-stimulating factor and neutrophils in patients with adult GH deficiency2005

    • Author(s)
      Sohmiya M, Kanazawa I, Kato Y
    • Journal Title

      European Journal of Endocrilology 152・2

      Pages: 211-215

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Human growth hormone and insulin-like growth factor-I inhibit erythropoietin secretion from the kidneys of adult rats.2005

    • Author(s)
      Sohmiya M, Kato Y
    • Journal Title

      Journal of Endocrinolology 184・1

      Pages: 199-207

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effect of recombinant human GH on circulating granulocyte clony-stimulating factor and neutrophils in patients wth adult GH deficiency2005

    • Author(s)
      Sohmiya M, IKanazawa I, Kato Y
    • Journal Title

      European Journal of Endocrilology 152(2)

      Pages: 211-215

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Human growth hormone and insulin-like growth factor-I inhibit erythropoietin secretion from the kidneys of adult rats.2005

    • Author(s)
      Sohmiya M, Kato Y
    • Journal Title

      Journal of Endocrinolology 184(1)

      Pages: 199-207

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effect of recombinant humab GH on circulating granulocyte clonystimulating factor and neutrophils in patients with adult GH deficiency2005

    • Author(s)
      Sohmiya M, IKanazawal, Kato Y
    • Journal Title

      European Journal of Endocrilology 152・2

      Pages: 211-215

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Human growth hormone and insulin-like growth factor-l inhibit erythropoietin secretion from the kidneys of adult rats.2005

    • Author(s)
      Sohmiya M, Kato Y
    • Journal Title

      Jounal of Endocrinolology 184・1

      Pages: 199-207

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Increased resting metabolic rate in patients with type 2 diabetes mellitus accompanied by advanced diabetic nephropathy.2004

    • Author(s)
      Nawata K, Sohmiya M, Kawaguchi M, Nishiki M, Kato Y
    • Journal Title

      Metabolism 53・11

      Pages: 1395-1398

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effect of erythropoietin on nitric oxide production in the rat hippocampus using in vivo brain microdialysis.2004

    • Author(s)
      Yamamoto M, Koshimura K, Sohmiya M, Murakami Y, Kato Y
    • Journal Title

      Neuroscience 128・1

      Pages: 163-168

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effect of tetrahydrobiopterin on nitric oxide synthase-containing cells in the rat hippocampus.2004

    • Author(s)
      Koshimura K, Murakami Y, Tanaka J, Yamamoto M, Kato Y.
    • Journal Title

      Neuroscience Research 50・2

      Pages: 161-167

    • NAID

      10014233494

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Serum levels of 20 kilodalton human growth hormone (20K-hGH) in patients with acromegaly before and after treatment with octreotide and transsphenoidal surgery.2004

    • Author(s)
      Murakami Y, Shimizu T, Yamamoto M, Kato Y.
    • Journal Title

      Endocrine Journal 51・3

      Pages: 343-348

    • NAID

      10013293031

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Increased resting metabolic rate in patients with type 2 diabetes mellitus accompanied by advanced diabetic nephropathy.2004

    • Author(s)
      Nawata K, Sohmiya M, Kawaguchi K, Nishiki M, Kato Y
    • Journal Title

      Metabolism 53(11)

      Pages: 1395-1398

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effect of erythropoietin on nitric oxide production in the rat hippocampus using in vivo brain microdialysis.2004

    • Author(s)
      Yamamoto M, Koshimura K, Sohmiya M, Murakami Y, Kato Y
    • Journal Title

      Neuroscience 128(1)

      Pages: 163-168

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effect of tetrahydrobiopterin on nitric oxide synthase-containing cells in the rat hippocampus.2004

    • Author(s)
      Koshimura K, Murakami Y, Tanaka J, Yamamoto M, Kato Y.
    • Journal Title

      Neuroscience Research 50(2)

      Pages: 161-167

    • NAID

      10014233494

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Serum levels of 20 kilodalton human growth hormone (20K-hGH) in patients with acromegaly before and after treatment with octreotide and transsphenoidal surgery.2004

    • Author(s)
      Murakami Y, Shimizu T, Yamamoto M, Kato Y.
    • Journal Title

      Endocrine Journal 51(3)

      Pages: 343-348

    • NAID

      10013293031

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Increased resting metabolic rate in patients with type 2 diabetes mellitus accompanied by advanced diabetic nepjropathy.2004

    • Author(s)
      Nawata K, Sohmiya M, Kawaguchi M, Nishiki M, Kato Y
    • Journal Title

      Metabolism 53・11

      Pages: 1395-1398

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Effect of erythropoietin on nitric oxide production in the rat hippocampus using in vive brain microdialysis.2004

    • Author(s)
      Yamamoto M, Koshimura K, Sohmiya M, Murakami Y, Kato Y
    • Journal Title

      Neuroscience 128・1

      Pages: 163-168

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Hypercholesterolemia and obesity in adult patients with hypopituitarism : a report of a nation-wide survey in Japan.2003

    • Author(s)
      Murakami Y, Kato Y.
    • Journal Title

      Endocrine Journal 50・6

      Pages: 759-765

    • NAID

      10011825583

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Hypercholesterolemia and obesity in adult patients with hypopituitarism : a report of a nation-wide survey in Japan.2003

    • Author(s)
      Murakami Y, Kato Y.
    • Journal Title

      Endocrine Journal 50(6)

      Pages: 759-765

    • NAID

      10011825583

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Expression of hypothalamic corticotropin-releasing hormone-like immunoreactivity in isolated ACTH deficiency : a report of an autopsied case.2003

    • Author(s)
      Mori T, Murakami Y, Nishiki M, Koshimura K, Sasano H, Kato Y.
    • Journal Title

      Journal of Endocrinological Investigation 26(6)

      Pages: 556-559

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Frequent appearance of autoantibodies against prohormone convertase 1/3 and neuroendocrine protein 7B2 in patients with nonfunctioning pituitary macroadenoma.2003

    • Author(s)
      Tatsumi KI, Tanaka S, Takano T, Tahara S, Murakami Y, Takao T, Hashimoto K, Kato Y, Teramoto A, Amino N.
    • Journal Title

      Endocrine 22(3)

      Pages: 335-340

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effect of high concentration of glucose on dopamine release from pheochromocytoma-12 cells.2003

    • Author(s)
      Koshimura K, Tanaka J, Murakami Y, Kato Y.
    • Journal Title

      Metabolism 52(7)

      Pages: 922-926

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Publications] T.Mori, Y.Murakami, K.Koshimura, H.Sasano, Y.Kato: "Expression of hypothalamic corticotropin-releasing hormon-like immunoreactivity in isolated ACTH deficiency : A report of an autopsied case"Journal of Endocrinological Investigation. 26. 556-559 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kunio Koshimura, Junko Tanaka, Yoshio Murakami, Yuzuru Kato: "Effect of high concentration of glucose on dopamine release from pheochromocytoma-12 cells"Metabolism. 52・7. 922-926 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Masahiro Yamamoto, Yoshio Murakami, Shigeyuki Tahara, Akira Teramoto, Masayuki Wada, Yuzuru Kato: "Severe osteoporosis in an adult patient with untreated child-onset Growth Hormone and gonadotropin deficiency"Clin Pediatr Endocrinol. 12・S20. 111-113 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 加藤 讓: "間脳下垂体疾患の診療の進歩と課題"日本内分泌学会雑誌. 79・S. 5-8 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yuko Yamane, Yoshio Murakami, Masateru Nishiki, Yuzuru Kato: "A case of idiopathic hypoparathyroidism associated with sensorineural deafness and mental retardation"Clin Pediatr Endocrinol. 12・S20. 97-99 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yoshio Murakami, Yuzuru Kato: "Hypercholesterolemia and obasity in adult patients with hypopituitarism : a report of a nation-wide survey in Japan"Endocrine Journal. 50・6. 759-765 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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