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The study on the mechanism of production of autoantibodies in autoimmune hemolytic anemia.

Research Project

Project/Area Number 15591018
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hematology
Research InstitutionJichi Medical School

Principal Investigator

KAMESAKI Toyomi  Jichi Medical School, Dept.of Medicine, Lecturer, 医学部, 講師 (90316513)

Co-Investigator(Kenkyū-buntansha) KUMADA Maki  Jichi Medical School, Dept.of Medicine, Lecturer, 医学部, 助手 (40326830)
OMI Toshinori  Jichi Medical School, Dept.of Medicine, Lecturer, 医学部, 助手 (40296091)
OKUDA Hiroshi  Jichi Medical School, Dept.of Medicine, Assistant Professor, 医学部, 助教授 (50285772)
IWAMOTO Sadahiko  Jichi Medical School, Dept.of Medicine, Professor, 医学部, 教授 (10232711)
KAJII Eiji  Jichi Medical School, Dept.of Medicine, Professor, 医学部, 教授 (40204391)
Project Period (FY) 2003 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2004: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2003: ¥2,100,000 (Direct Cost: ¥2,100,000)
Keywordsautoimmune hemolytic anemia / Rh blood groups / mimotope / autoantibody / random peptide library / band 3 / linear peptide / molecular mimicry / ミモトープ / Coombs陰性自己免疫性溶血性貧血 / CD47 / 交叉反応
Research Abstract

Rh polypeptides, especially RhCcEe, are the common autoantigens in autoimmune hemolytic anemia (AIHA). Rh blood group antigens and the autoantigens in AIHA are conformational antigens and constructed by six extracellular loops of Rh polypeptides. Identification of replica of autoantigen epitopes (mimotope) was performed by means of screening phage displayed random peptide library.
1.Identification of Rh mimotopes, reacting monoclonal anti-D antibody and/or anti-E antibody.
2.Identification of autoantigen mimotopes, reacting autoantibody from AIHA patients.
3.Six out of eight of the autoantibodies reacted the Rh mimotopes, therefore it is assumed that the Rh mimotopes might be included into autoantigen mimotopes.
4.These mimotopes will make it possible to identify and categorize autoantibodies in AIHA, to map epitopes of autoantigens on Rh peptides and to verify molecular mimicry between foreign antigens and Rh polypeptides as the etiology of autoantibodies in AIHA.

Report

(3 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • Research Products

    (43 results)

All 2005 2004 2003 Other

All Journal Article (37 results) Book (2 results) Publications (4 results)

  • [Journal Article] 自己免疫性溶血性貧血の分子病態2005

    • Author(s)
      亀崎豊実
    • Journal Title

      臨床血液 46

      Pages: 307-316

    • NAID

      130005093116

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 自己免疫性溶血性貧血2005

    • Author(s)
      亀崎豊実
    • Journal Title

      日本臨床 63

      Pages: 432-442

    • NAID

      10031123095

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 溶血性貧血2005

    • Author(s)
      亀崎豊実
    • Journal Title

      血液フロンティア 15

      Pages: 741-750

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 自己免疫性溶血性貧血の標的抗原エピトープ2005

    • Author(s)
      亀崎豊実
    • Journal Title

      臨床免疫 43(印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Molecular mechanisms of Autoimmune hemolytic anemia.2005

    • Author(s)
      Kamesaki T, Kajii E.
    • Journal Title

      Rinshoketsueki 46

      Pages: 307-316

    • NAID

      10015708913

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Autoimmune hemolytic anemia.2005

    • Author(s)
      Kamesaki T, Kajii E.
    • Journal Title

      Nippon Rinsho 63

      Pages: 432-442

    • NAID

      10031123095

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Hemolytic anemia.2005

    • Author(s)
      Kamesaki T, Kajii E.
    • Journal Title

      Hematology Frontier 15

      Pages: 741-750

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Epitopes of the target autoantigens in autoimmune hemolytic anemia.2005

    • Author(s)
      Kamesaki T.
    • Journal Title

      Clinical Immunology 43

      Pages: 487-493

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] ブタRhesus(RH)遺伝子のcDNAクローニング、マッピング、多型解析2004

    • Author(s)
      近江俊徳
    • Journal Title

      DNA多型 12

      Pages: 12-15

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] ハプトグロビン(Hp)2004

    • Author(s)
      亀崎豊実
    • Journal Title

      内科 93・6

      Pages: 1052-1052

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Donath-Landsteiner抗体2004

    • Author(s)
      亀崎豊実
    • Journal Title

      内科 93・6

      Pages: 1074-1074

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 寒冷凝集素2004

    • Author(s)
      亀崎豊実
    • Journal Title

      内科 93・6

      Pages: 1173-1173

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Coombs試験2004

    • Author(s)
      亀崎豊実
    • Journal Title

      内科 93・6

      Pages: 1172-1172

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 抗血小板抗体2004

    • Author(s)
      亀崎豊実
    • Journal Title

      内科 93・6

      Pages: 1245-1245

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 血小板関連抗体(PAIgG)2004

    • Author(s)
      亀崎豊実
    • Journal Title

      内科 93

      Pages: 1053-1053

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] cDNA cloning, mapping and polymorphism of the porcine Rhesus(RH) gene.2004

    • Author(s)
      Omi T, Kumada M, Kamesaki T, Okuda H, Kajii E, Iwamoto S, Vogeli P, Schelling C, Stranzinger G
    • Journal Title

      DNA Polymorphism 12

      Pages: 12-15

    • NAID

      10013660627

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Haptoblobin.2004

    • Author(s)
      Kamesaki T, Kajii E.
    • Journal Title

      INTERNAL MEDICINE 93

      Pages: 1052-1052

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Donath-Landsteiner antibody.2004

    • Author(s)
      Kamesaki T, Kajii E.
    • Journal Title

      INTERNAL MEDICINE 93

      Pages: 1074-1074

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Cold agglutinin.2004

    • Author(s)
      Kamesaki T, Kajii E.
    • Journal Title

      INTERNAL MEDICINE 93

      Pages: 1173-1173

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Coombs test.2004

    • Author(s)
      Kamesaki T, Kajii E.
    • Journal Title

      INTERNAL MEDICINE 93

      Pages: 1172-1172

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] anti-platelet antibody.2004

    • Author(s)
      Kamesaki T, Kajii E.
    • Journal Title

      INTERNAL MEDICINE 93

      Pages: 1245-1245

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Platelet associated antibody.2004

    • Author(s)
      Kamesaki T, Kajii E.
    • Journal Title

      INTERNAL MEDICINE 93

      Pages: 1053-1053

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Cold aggulutin disease.2004

    • Author(s)
      Kamesaki T, Kajii E.
    • Journal Title

      Questions & Answers 38

      Pages: 204-207

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] ブタRhesus(RH)遺伝子のcDNAクローニング、マッピング、多型解析2004

    • Author(s)
      近江俊徳, 熊田真樹, 亀崎豊実, 奥田浩, 梶井英治, 岩本禎彦
    • Journal Title

      DNA多型 12

      Pages: 12-15

    • Related Report
      2004 Annual Research Report
  • [Journal Article] ハプトグロビン(Hp)2004

    • Author(s)
      亀崎豊実, 梶井英治
    • Journal Title

      内科 93・6

      Pages: 1052-1052

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Donath-Landsteiner抗体2004

    • Author(s)
      亀崎豊実, 梶井英治
    • Journal Title

      内科 93・6

      Pages: 1074-1074

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 寒冷凝集素2004

    • Author(s)
      亀崎豊実, 梶井英治
    • Journal Title

      内科 93・6

      Pages: 1173-1173

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Coombs試験2004

    • Author(s)
      亀崎豊実, 梶井英治
    • Journal Title

      内科 93・6

      Pages: 1172-1172

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 抗血小板抗体2004

    • Author(s)
      亀崎豊実, 梶井英治
    • Journal Title

      内科 93・6

      Pages: 1245-1245

    • Related Report
      2004 Annual Research Report
  • [Journal Article] A novel mutation inthe RHD gene in Japanese individuals with week D, encoding an amino acid change in the 11th transmembranous domein of the RhD protein transmembranous portion2003

    • Author(s)
      Kamesaki T
    • Journal Title

      Vox Sang 84・2

      Pages: 141-141

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] DNA-based identification resolved suspected misdiagnosis due to contaminated cytological specimens.2003

    • Author(s)
      Iwamoto S
    • Journal Title

      Leg Med 5・4

      Pages: 246-250

    • NAID

      50000002091

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] cDNA cloning, mapping and polymorphism of the porcine Rhesus (RH) gene.2003

    • Author(s)
      Omi T
    • Journal Title

      Anim Genet 34・3

      Pages: 176-182

    • NAID

      10013660627

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] ラットABOホモログの遺伝子重複とその多型2003

    • Author(s)
      岩本禎彦
    • Journal Title

      DNA多型 11・1

      Pages: 38-41

    • NAID

      10013995330

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A novel mutation in the RHD gene in Japanese individuals with weak D, encoding an amino acid change in the 11th transmembranous domain of the RhD protein transmembranous portion of the RhD protein.2003

    • Author(s)
      Kamesaki T, Kumada M, Omi T, Okuda H, Iwamoto S, Takahashi J, Kimura K, Hirayama F, Kamata H, Obara K, Taniguchi M, Tani Y, Kajii E.
    • Journal Title

      Vox Sang. 84

      Pages: 141-141

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] DNA-based identification resolved suspected misdiagnosis due to contaminated cytological specimens.2003

    • Author(s)
      Iwamoto S, Kamesaki T, Kumada M, Omi T, Okuda H, Hasegawa T, Sakurai S, Kajii E.
    • Journal Title

      Leg Med 5

      Pages: 246-250

    • NAID

      50000002091

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] cDNA cloning, mapping and polymorphism of the porcine Rhesus(RH) gene.2003

    • Author(s)
      Omi T, Vogeli P, Hagger C, Schelling C, Spilar S, Kajii E, Stranzinger G, Neuenschwander S.
    • Journal Title

      Anim Genet 34

      Pages: 176-182

    • NAID

      10013660627

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Gene duplication and polymorphism of rat ABO homologue.2003

    • Author(s)
      Iwamoto S, Kumada M, Kamesaki T, Okuda H, Kajii E.
    • Journal Title

      DNA Polymorphism 11

      Pages: 38-41

    • NAID

      10013995330

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] 内科診療Q&A第38号:冷式抗体による自己免疫性溶血性貧血2004

    • Author(s)
      亀崎豊実
    • Total Pages
      4
    • Publisher
      六法出版
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] 内科診療Q&A第38号:冷式抗体による自己免疫性溶血性貧血2004

    • Author(s)
      亀崎豊実, 梶井英治
    • Total Pages
      4
    • Publisher
      六法出版
    • Related Report
      2004 Annual Research Report
  • [Publications] Kamesaki T: "A novel mutation inthe RHD gene in Japanese individuals with weak D, encoding an amino acid change in the 11th transmembranous domain of the RhD protein"Vox Sang. 84・2. 141 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Iwamoto S: "DNA-based identification resolved suspected misdiagnosis due to contaminated cytological specimens."Leg Med. 5・4. 246-250 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Omi T: "cDNA cloning, mapping and polymorphism of the porcine Rhesus (RH) gene."Anim Genet. 34・3. 176-182 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 岩本禎彦: "ラットABOホモログの遺伝子重複とその多型"DNA多型. 11・1. 38-41 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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