Development of tumor-specific DNA vaccines eradicating metastatic lesions
| Project/Area Number |
15591042
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Tohoku University |
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Principal Investigator |
SANO Kunio Tohoku University, Graduate School of Medicine, Associate Professor, 大学院・医学系研究科, 助教授 (20192601)
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| Project Period (FY) |
2003 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2004: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2003: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | CpG ODN / Th1 cells / antigen-presenting cells / antigen-specific / tumor-specific immunity / 腫瘍免疫 / CpG DNA / 転移 |
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| Research Abstract |
Although melanoma mostly affects the skin, it is notorious for its propensity to easily develop metastasis. Metastatic melanoma is highly resistant to a variety of therapies. We examined the anti-metastatic potential of peritumoral monotherapy against murine cutaneous B16F10 melanoma with synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs. We demonstrated that repeated peritumoral injections of CpG ODNs significantly reduced skin tumor size. Peritumoral CpG ODN-treatment of skin tumors prevented the development of pulmonary B16F10 colonies. Adoptive transfer of splenocytes obtained from CpG ODN-treated mice markedly reduced the number of previously established pulmonary colonies in recipient naive mice. T-lymphocyte depletion studies indicated that the anti-metastatic effect was dependent on both CD4^+ and CD8^+ T cells. These results suggest that CpG ODNs are promising as a preventive and therapeutic anti-metastatic measure against melanoma.
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Report
(3 results)
Research Products
(17 results)
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[Journal Article] Peritumoral CpG oligodeoxynucleotide treatment inhibits experimental metastasis of skin melanoma to the lung2004
Author(s)
Kunikata, N, K.Sano, M.Honda1, K.Ishii, J.Matsunaga, R.Okuyama, K.Takahashi, H.Watanabe, G.Tamura, H.Tagami, T.Terui
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Journal Title
J.Invet.Dermatol. 123
Pages: 395-402
Description
「研究成果報告書概要(欧文)」より
Related Report
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