Molecular mechanisms in activation of mast cells through FcεRI anf Toll-like receptor
| Project/Area Number |
15591047
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | The University of Tokyo |
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Principal Investigator |
OTA Yasuo The University of Tokyo, Faculty of Medicine, Research Associate, 医学部附属病院, 助手 (80292936)
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| Project Period (FY) |
2003 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2004: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2003: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | mast cells / FCεRI / TLR4 / histamine / LPS / F_<ce>RI / TLR / PBL-2HC / TNF-α / 自然免疫 |
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| Research Abstract |
Mast cells are involved in not only allergic responses but also host defense to such pathogenic microorganisms as gram negative rods (GNR) and parasites. Recently, it has been reported that mast cells express Toll-like receptor (TLR) 4 which is important for recognition for LPS of GNR. It is speculated that mast cells are activated by several signal trunsduction cascades at the same time. So it is important for examining the relationship between different signal trunsduction cascades. In this study we examined histamine release after stimulation by DNP・IgE plus DNP・HAS in cells atimulated with and without LPS. Released histamine was decreased in cells pretreated with LPS. However, the results were not significantly different. In addition, DNP・IgE itself induced histamine release. To determine whether signal trunsduction cascades through TLR4 regulates histamine release through FcεRI, it is necessary to have IgE that does not induce histamine release by itself.
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Report
(3 results)
Research Products
(20 results)
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[Journal Article] Involvement of IRAK-M in Peptidoglycan-induced Tolerance in Macrophages.2004
Author(s)
Nakayama K, Okugawa S, Yanagimoto S, Kitazawa T, Tsukada K, Kawada M, Kimura S, Hiraib K, Takagaki Y, Ota Y.
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Journal Title
J, Biol, Chem 2004, 279(8)
Pages: 6629-6634
Description
「研究成果報告書概要(欧文)」より
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