genetic analysis for rheumatoid arthritis patients complicated with renal disorders
| Project/Area Number |
15591052
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Niigata University |
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Principal Investigator |
NAKANO Masaaki Niigata University, Institute of Medicine and Dentistry, Professor, 医歯学系, 教授 (90198169)
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| Project Period (FY) |
2003 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2005: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 2004: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2003: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | rheumatoid arthritis / renal disorder / amyloidosis / Apolipoprotein E / 合併症 / 続発性アミロイドーシス / 血清アミロイドA蛋白 / アミロイド腎 |
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| Research Abstract |
OBJECTIVE : To determine whether serum Apolipoprotein E (Apo E) type 4 isoprotein is a risk factor for the development of amyloidosis in patients with rheumatoid arthritis (RA).
METHODS : Using isoelectric focusing, we studied Apo E phenotype expression and the corresponding allele frequencies (epsilon 2, epsilon 3, and epsilon 4) in 68 RA patients complicated with amyloidosis, 171 RA patients without amyloidosis.
RESULTS : The Apo E3/4 phenotype was significantly more common in the group with amyloidosis (26.5%) than in the patients without amyloidosis (15.2% ; P<0.05). RA amyloidosis patients with Apo E4 isoprotein had significantly poor survival than those without Apo E4 isoprotein.
CONCLUSION : The presence of Apo E4 isoprotein may be a risk factor for the development of amyloidosis in patients with RA. Furthermore, Apo E4 isoprotein may be a marker of poor survival for RA patients complicated with amyloidosis.
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Report
(4 results)
Research Products
(15 results)
