INF-α productivity and Toll-like receptor 3 gene polymorphism in patients with febrile seizure
| Project/Area Number |
15591117
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Saga University (2004)
佐賀医科大学 (2003) |
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Principal Investigator |
MATSUO Muneaki Saga University, Pediatrics, clinical fellow, 医学部, 助手 (20219398)
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| Co-Investigator(Kenkyū-buntansha) |
MIYAKE Kensuke Tokyo University, Medical Science Institute, Professor, 医科学研究所・感染遺伝学分野, 教授 (60229812)
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| Project Period (FY) |
2003 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 2004: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2003: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | febrile seizure / double-stranded RNA(dsRNA) / Toll-like receptor 3(TLR3) / IL-1β / IFN-α / Toll-like receptor / IL-1 / IFN-α |
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| Research Abstract |
Objective To examine the possibility that children with and without a history of febrile seizures(FS) might mount different immune responses to double-stranded RNA(dsRNA), which is a common viral factor that induces host cell immune responses, and is recognized by Toll-like receptor 3(TLR3).
Study design The production of IL-1β and IFN-α from dsRNA-stimulated leukocytes was examined in 27 children (age,3.6±0.3) with, and 18 children (age,3.4±0.2) without, a history of FS.
Results Significantly (p=0.0007) increased IL-1β production was observed in children with a history of FS, compared with controls. When patients with a single prior episode of FS (n=9) and those with multiple prior episodes of FS (n=18) were compared, a significant difference in IL-1β production was not observed. Genotyping of IL-1β(-511),TLR3,Toll-IL-1 receptor domain-containing adapter inducing interferon-β (TRIF), and IL-1 receptor antagonist(IL-1RA) polymorphisms revealed no significant differences in allelic distribution among FS patients and controls. IL-1β production was not significantly influenced by genotype.
Conclusion Viral infection results in increased IL-1β production in FS patients and that this may play a role in FS.
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Report
(3 results)
Research Products
(6 results)
