| Project/Area Number |
15591159
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Kagawa University |
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Principal Investigator |
KUSAKA Takashi Kagawa University, Faculty of Medicine, Maternal Perinatal Center, Lecturer, 医学部附属病院, 講師 (50274288)
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| Co-Investigator(Kenkyū-buntansha) |
KAWADA Kow Kagawa University, Faculty of Medicine, Maternal Perinatal Center, Assistant professor, 医学部附属病院, 助手 (40284369)
OKADA Hitoshi Kagawa University, Faculty of Medicine, Department of Pediatrics, Assistant professor, 医学部附属病院, 助手 (30253272)
OHKUBO Kensuke Kagawa University, Faculty of Medicine, Department of Pediatrics, Assistant professor, 医学部, 助手 (80335851)
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| Project Period (FY) |
2003 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2004: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2003: ¥2,900,000 (Direct Cost: ¥2,900,000)
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| Keywords | Infant / Functional imaging / Optical imaging / Passive movement / Sensorimotor cortex / Near-infrared spectroscopy / Multi-channel / Topography |
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| Research Abstract |
Multi-channel near-infrared spectroscopy (NIRS) was used for functional imaging of the sensorimotor cortex of newborn infants during passive knee and elbow movement under sedated sleep. Contralateral knee and elbow movement caused a marked increase in concentration of oxyhemoglobin [oxyHb] and total hemoglobin [totalHb] from the baseline values at locations in the sensorimotor area of all infants. During ipsilateral knee and elbow movement, [oxyHb] showed slighter changes, equivalent to 64±23 % and 66±28% of the changes that occurred with contralateral stimulation, respectively. The mean times corresponding to maximal changes in [oxyHb] were 16.1 ± 3.3 sec for contralateral knee stimulus, 17.9±5.7 sec for contralateral elbow stimulus, respectively. The mean time corresponding to maximal changes in [oxyHb] were not statistically significant between during contralateral and ipsilateral knee stimulus or elbow stimulus.
This study has shown that sensorimotor area function in response to passive motor stimulation of the knee and elbow joint can be imaged and evaluated even in newborn infants during sleep under sedation. Data obtained by multi-channel NIRS should be useful for understanding the pathophysiology of the developing regional brain and the brain's response to damage in various clinical situations.
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