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Polysomnographic study of the pathogenesis of refractory akathisia and restless legs syndrome.

Research Project

Project/Area Number 15591226
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionSHIMANE UNIVERSITY (2004)
Shimane Medical University (2003)

Principal Investigator

HORIGUCHI Jun  SHIMANE UNIVERSITY MEDICAL SCHOOL, DEPARTMENT OF PSYCHIATRY, PROFESSOR, 医学部, 教授 (90136317)

Co-Investigator(Kenkyū-buntansha) INAGAKI Takuji  SHIMANE UNIVERSITY MEDICAL SCHOOL, DEPARTMENT OF PSYCHIATRY, ASSOCIATE PROFESSOR, 医学部, 助教授 (80176388)
MIYAOKA Tuyoshi  SHIMANE UNIVERSITY MEDICAL SCHOOL, DEPARTMENT OF PSYCHIATRY, LECTURER, 医学部, 講師 (50284047)
MIZUNO Soichi  SHIMANE UNIVERSITY MEDICAL SCHOOL, DEPARTMENT OF PSYCHIATRY, LECTURER, 医学部, 講師 (80335562)
Project Period (FY) 2003 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2004: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2003: ¥2,000,000 (Direct Cost: ¥2,000,000)
Keywordsrestless legs syndrome / polysomnography / sleep / akathisia / nocturnal myclonus / iron / drug treatment / risperidone / レストレス・レッグス症候群
Research Abstract

1)Patients with restless legs syndrome demonstrated high frequency of PLM index, and the PLM indices decreased with the improvement of restless legs symptoms after the various drug treatments.
2)Iron treatment improved the restless legs syndrome with and without iron defficiency with the decrease of the PLM.
3)With the improvement of antipsychotic-induced akathisia after the drug treatment, the patients showed the decrease of the PLM and Arousal indices and the increse of total sleep time and the percentages of stage 2 and slow wave sleep.
4)Patients with restless legs syndrome showed low brain iron concentration without low serum iron.
5)The trial of the administration of risperidone to the healthy subjects suggests that risperidone treatment may have sleep efficacy to schizophrenic patients.

Report

(3 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • Research Products

    (26 results)

All 2005 2004 2003 Other

All Journal Article (17 results) Book (2 results) Publications (7 results)

  • [Journal Article] Proton magnetic resonance spectroscopy (1H-MRS) of hippocampus, basal ganglia, and vermis of cerebellum in schizophrenia associated with idiopathic unconjugated hyperbilirubinemia (Gilbert's syndrome).2005

    • Author(s)
      Miyaoka T, et al.
    • Journal Title

      Journal of Psychiatric Research 39

      Pages: 29-34

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] CSF Iron, Ferritin, and Transferrin Levels in Restless Legs Syndrome.2005

    • Author(s)
      Mizuno S, et al.
    • Journal Title

      Journal of Sleep Research 14

      Pages: 43-47

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Proton magnetic resonance spectroscopy (1H-MRS) of hippocamaus, basal ganglia, and vermis of cerebellum in schizophrenia associated with idiopathic unconjugated hyperbilirubinemia (Gilbert's syndrome).2005

    • Author(s)
      Miyaoka T, et al.
    • Journal Title

      Journal of Psychiatric Research 39

      Pages: 29-34

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] CSF Iron, Ferritin and Transferrin Levels in Restless Legs Syndrome.2005

    • Author(s)
      Mizuno S, et al.
    • Journal Title

      Journal of Sleep Research 14

      Pages: 43-47

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Proton magnetic resonance spectroscopy (1H-MRS) of hippocampus, basal ganglia, and vermis of cerebellum in schizophrenia associated with idiopathic unconjugated hyperbilirubinemia (Gilbert's syndrome).2005

    • Author(s)
      Miyaoka T, et al.
    • Journal Title

      Journal of Psychiatric 39巻

      Pages: 29-34

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 抗精神病薬の長期投与に伴う錐体外路症状への対策2005

    • Author(s)
      宮岡 剛 ほか
    • Journal Title

      精神科治療学 20・2

      Pages: 117-124

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Effect of donepezil on Alzheimer's disease : The relationship between congnitive function and rapid eye movement sleep.2004

    • Author(s)
      Mizuno S, et al.
    • Journal Title

      Psychiatry and Clinical Neurosciences 58

      Pages: 660-665

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Breath-holding spells in somatoform disorder.2004

    • Author(s)
      Inagaki T, et al.
    • Journal Title

      International Journal of Psychiatry in Medicine 34

      Pages: 201-205

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Breath-holing spels in somatoform disorder.2004

    • Author(s)
      Inagaki T, et al.
    • Journal Title

      International Journal of Psychiatry in Medicine 34

      Pages: 201-205

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effect of donepezil on Alzheimer's disease : The relationship between congnitive function and rapid eye movement sleep.2004

    • Author(s)
      Mizuno S, et al.
    • Journal Title

      Psychiatry and Clinical Neurosciences 58巻

      Pages: 660-665

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Breath-holding spells in somatoform disorder.2004

    • Author(s)
      Inagaki T, et al.
    • Journal Title

      International Journal of Psychiatry in Medicine 34・2

      Pages: 201-205

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Restless Legs症候群に関する研究.1)本邦における疫学.2)病態機序-脳脊髄液中の鉄、フェリチン、トランスフェリンの動態-2004

    • Author(s)
      水野創一 ほか
    • Journal Title

      Progress in Medicine 24・3

      Pages: 232-237

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 睡眠と不随意運動2003

    • Author(s)
      水野創一ほか
    • Journal Title

      Clinical Neuroscience 22

      Pages: 73-75

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Involuntary movements during sleep.2003

    • Author(s)
      Mizuno S, et al.
    • Journal Title

      Clinical Neuroscience 22

      Pages: 73-75

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Prevalence of Restless Legs Syndrome in a Non-Institutionalized Japanese Elderly.

    • Author(s)
      Mizuno S, et al.
    • Journal Title

      Psychiatry and Clinical Neurosciences (in press)

    • NAID

      10024578187

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Prevalence of Restless Legs Syndrome in a Non-Institutionalized Japanese Elderly.

    • Author(s)
      Mizuno S, et al.
    • Journal Title

      Psychiatry and Clinical Neurosciences (in press)

    • NAID

      10024578187

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] CSF Iron, Ferritin, and Transferrin Levels in Restless Legs Syndrome.

    • Author(s)
      Mizuno S, et al.
    • Journal Title

      Journal of Sleep Research (in press)

    • Related Report
      2004 Annual Research Report
  • [Book] 不眠-睡眠薬の使い方(P689-690、分担執筆) 2004今日の治療指針2004

    • Author(s)
      堀口 淳
    • Total Pages
      2
    • Publisher
      医学書院
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] 不眠-睡眠薬の使い方(分担執筆)2004今日の治療指針2004

    • Author(s)
      堀口 淳
    • Publisher
      医学書院
    • Related Report
      2004 Annual Research Report
  • [Publications] Kishi Tほか: "Postictal psychosis coexisting with forced thiking"General Hospital Psychiatry. 25. 51-60 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Inagaki Tほか: "Echocardiographic investigation of pericardial effusion in a case of Anorexia Nervosa"International Journal of Eating Disorders. 33・3. 364-366 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 稲見康司ほか: "高齢者の睡眠障害の疫学"老年医学. 41・4. 488-493 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Miyaoka Tほか: "Successful treatment of nocturnal eating/drinking syndrome with seliecitive serotonin reuptake inhibitors"International Clinical Psychopharmacology. 18・3. 175-177 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sukegawa Tほか: "Sleep disturbances and depression in the elderly in Japan"Psychiatry and Clinical Neurosciences. 57. 265-270 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 水野創一ほか: "睡眠と不随意運動"Clinical Neuroscience. 22・1. 73-75 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 水野創一ほか: "(分担執筆)典型的な高齢者の睡眠障害.久保木富房編:睡眠障害診療マニュアル"ライフ・サイエンス(東京). 5 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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