| Project/Area Number |
15591232
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | OITA UNIVERSITY (2004)
大分医科大学 (2003) |
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Principal Investigator |
AKIYOSHI Jotaro OITA UNIVERSITY, FACULTY OF MEDICINE, ASSOCIATE PROFESSOR, 医学部, 助教授 (00159344)
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| Co-Investigator(Kenkyū-buntansha) |
ISOGAWA Koichi OITA UNIVERSITY, FACULTY OF MEDICINE, ASSISTANT PROFFESOR, 医学部, 講師 (10264334)
TSUTSUMI Takashi OITA UNIVERSITY, FACULTY OF MEDICINE, RESEARCH ASSISTANT, 医学部, 助手 (60284791)
永山 治男 大分大学, 医学部, 教授 (70100899)
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| Project Period (FY) |
2003 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2004: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2003: ¥2,500,000 (Direct Cost: ¥2,500,000)
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| Keywords | HGF / ANXIETY / TRANSJENICMICE |
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| Research Abstract |
BACKGROUND : Hepatocyte growth factor(HGF) has the capacity to selectively direct thalamocortical projections into an intermediate target, the pallidum, and eventually to their final cortical destination. HGF may have a role in the mediation of anxiety. Very little is known about other central behavioral effects of HGF. OBJECTIVE : Our aim was to determine what effect HGF has on anxiety in rats. METHODS : HGF was infused at a constant rate into cerebral lateral ventricles and its effect on anxiety in rats was monitored. RESULTS : In the elevated plus maze test and the black and white box test, HGF administration caused all indicators of anxiety to increase. No significant effect on general locomotor activity was seen. CONCLUSION : HGF infusion into the brain produces an anxiolytic effect.
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