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The addiction and side effects of Psychotropic drugs (Psychoactivating substances)

Research Project

Project/Area Number 15591244
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionAzabu University

Principal Investigator

IWAHASHI Kazuhiko  Azabu University, College of Environmental Health, Professor, 環境保健学部, 教授 (00232695)

Co-Investigator(Kenkyū-buntansha) YOSHIHARA Eiji  Azabu University, College of Environmental Health, Associate Professor, 環境保健学部, 助教授 (80147975)
AMENO Kiyoshi  Kagawa University, Faculty of Medicine, Associate Professor, 医学部, 助教授 (50019626)
Project Period (FY) 2003 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 2006: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2005: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2004: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2003: ¥700,000 (Direct Cost: ¥700,000)
KeywordsCYP2D6 / tailor made medicine / psychotropic drugs / 薬物依存 / 副作用 / 精神活性物質 / ニコチン / 依存 / セロトニン / 遺伝子多型 / CYP2E1 / CYP1A2 / オランザピン
Research Abstract

We performed to analyzed the relation ships between side effects of psychotropic drugs and the drug metabolizing enzymes CYP1A2, 2A6,2C19 and 2D6 As a help of tailor maid medicine establishment.
After written informed consent was obtained, the relation ship between mechanism of side effects of psychotropic drugs and the genotypes of CYPs were investigated among schizophrenic patients.
It was shown that the side effect of neuroleptics (Olanzapine), hyper glycemia might be affected by the genotype of CYP2D6 (CYP2D6*5, 10), rather than CYP1A2 (CYP1A2*1C, *1F).
In this study, we registered "Genoscan tailor maid service" as a trademark.
Further studies with larger subjects in side effects of psychotropic drugs are necessary for to raise safety of medicine.

Report

(5 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (18 results)

All 2006 2005 2004 2003 Other

All Journal Article (14 results) Book (2 results) Publications (2 results)

  • [Journal Article] Olanzapineが体重、糖脂質代謝に与える影響。2006

    • Author(s)
      渡辺全朗
    • Journal Title

      精神医学 48

      Pages: 29-29

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The Effects of Olanzapine on Weight, Glucose and Lipid Levels.2006

    • Author(s)
      Watanabe M.
    • Journal Title

      Seishin Igaku 48

      Pages: 29-35

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Olanzapineが体重、糖脂質代謝に与える影響2006

    • Author(s)
      渡辺全朗, 内藤智道, 岩橋和彦
    • Journal Title

      精神医学 48

      Pages: 29-35

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Linkage disequilibrium and association with methamphetamine dependence/psychosis of mopioid receptor gene polymorphisms2006

    • Author(s)
      S Idel, H Kobayashi, H Ujike, N Ozaki, Y Sekine, T Inada, M Harano, T Komiyama, M Yamada, M Iyo, N Iwata, K Tanaka, H Shenl, K Iwahashi, M Itokawa, M Minami, M Satoh, K Ikeda, I Sora
    • Journal Title

      harmacogenomics J. 5

      Pages: 179-188

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Cholecystokinin(CCK) and the CCKA receptor gene polymorphism, and smoking behavior.2005

    • Author(s)
      Takimoto T.
    • Journal Title

      Psychiat Res. 133

      Pages: 123-123

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 日本人高血圧患者の頚動脈エコーによる内膜中膜複合体複合体壁厚およびプラークと高血圧候補遺伝子多型-動脈硬化症患者疾患の早期発見の可能性について-2005

    • Author(s)
      寺島茂
    • Journal Title

      臨床病理 53

      Pages: 290-296

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Whole deletion of CYP2A6 gene (CYP2A6AST;4C) and smoking behavior.2004

    • Author(s)
      Iwahashi K.
    • Journal Title

      Neuropsychobiology 49

      Pages: 195-195

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The serotonin-2A receptor polymorphism and smoking behavior in Japan.2004

    • Author(s)
      Terayama H.
    • Journal Title

      Psychiat Genet. 14

      Pages: 195-195

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Olanzapine metabolism by CYP1A2/CYP2D6 and hyperglycemia.2004

    • Author(s)
      Iwahashi K.
    • Journal Title

      Acta Neuropsychiatr. 16

      Pages: 229-229

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Whole deletion of CYP2A6 gene (CYP2A6AST;4C) and smoking behavior.2004

    • Author(s)
      Iwahashi K.
    • Journal Title

      Neuropsychobiology. 49(2)

      Pages: 101-104

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Olanzapine metabolism by CYPlA2/CYP2D6 and hyperglycemia.2004

    • Author(s)
      Iwahashi K.
    • Journal Title

      Acta Neuropsychiatr. 16

      Pages: 229-230

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The serotonin-2A receptor polymorphism and smoking behavior in Japan2004

    • Author(s)
      Terayama T, Iwahashi K., (Corresponding autho), et al.
    • Journal Title

      Psychiatric Genetics 14

      Pages: 195-198

    • Related Report
      2004 Annual Research Report
  • [Journal Article] The serotonin-2A receptor polymorphism and clinical symptoms in mood disorders, schizophrenia and alcohol dependence in Japan.2003

    • Author(s)
      Terayama H.
    • Journal Title

      Acta Psychiatr. 15

      Pages: 129-129

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Major depression and heat shock protein 70-1 gene.2003

    • Author(s)
      Takimoto T.
    • Journal Title

      Clin Chhim Acta. 332

      Pages: 133-133

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] 精神科医療サービスを上手に受ける方法2005

    • Author(s)
      岩橋 和彦
    • Total Pages
      239
    • Publisher
      法研
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] 統合失調症 治療を拒むときに読む本2005

    • Author(s)
      岩橋 和彦, (福西勇夫 編)
    • Total Pages
      154
    • Publisher
      法研
    • Related Report
      2005 Annual Research Report
  • [Publications] 岩橋和彦 他: "OlanzapineのCYP1A2およびCYP2D6による代謝-血中濃度と副作用について-"臨床精神医学. 32. 689-693 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Nakamura K., Iwahashi K., et al.: "CYP2E1 and Clinical features in alcoholics"Neuropsychobiology. 47. 86-89 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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