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Research on the indication of cognitive behavioral therapy and graded exercise in chronic fatigue syndrome

Research Project

Project/Area Number 15591246
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionKansai University of Welfare Sciences

Principal Investigator

SHIMIZU Akira  Kansai University of Welfare Sciences, Faculty of Social Welfare, Professor, 社会福祉学部, 教授 (90028457)

Co-Investigator(Kenkyū-buntansha) KURATSUNE Hirohiko  Kansai University of Welfare Sciences, Faculty of Health Sciences for Welfare, Professor, 健康福祉学部, 教授 (50195533)
IWASE Masao  Osaka University Graduate School of Medicine, Psychiatry, Department of Clinical Neuroscience, Instructor, 大学院・医学系研究科・精神医学教室, 助手 (60362711)
Project Period (FY) 2003 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2004: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2003: ¥2,000,000 (Direct Cost: ¥2,000,000)
Keywordschronic fatigue syndrome / cognitive behavioral therapy / psychiatric classification of disease course / CFS / 疲労度 / 認知の歪み / うつ症状
Research Abstract

We classified the patients who attended the Fatigue Clinic of the Department of Hematology and Oncology, Osaka University Hospital into four groups by a psychiatric interview based on SCID in the Department of Psychiatry, Osaka University Hospital. These four groups consisted of a group without psychiatric disorders (Group I), a group with subsequent psychiatric disorders (Group II), a group which could be simultaneously diagnosed as psychiatric disorders at the first onset of chronic fatigue syndrome (CFS), and a group which fulfilled the exclusion criteria (Exclusion Group). We mainly included patients in Group I in the present research. The patients received 10 sessions (45 minutes per 2week) of cognitive behavioral therapy (CBT). The assessment, PDQ-R, SSAS, CISS and Holmes & Rahe's Scale, Jikakusho-Shirabe, JIBT, SDS, MOS-SF36 were measured before and after the therapy. The contents of CBT comprised modification of cognitive distortions which could prolong fatigue (overadaptation, … More avoidance of physical activity, obsession on the somatic symptoms, etc.) by interviews and activity charts, appropriate planning and execution of work and rest, and gradual increase of activity. Although the therapy indicated preferable effects in the patients, the effects were different in each cases and it was suggested that uniformed evaluation could fail to detect the effectiveness of CBT for CFS. In applying CBT to Japanese patients with CFS, there were several important points. First, we emphasize necessity for cooperation of physician, psychiatrist and CBT psychologist. Second, as a first intervention, behavioral technique seemed more suitable than cognitive technique. Third, objective methods to evaluate therapeutic effects were required. At present, we published several articles on the psychiatric screening interview and overview of CBT for CFS in Japan. We are now preparing an article on the prognosis of CFS which indicates that patients in Group III showed poorer prognosis of medical treatment by physician. Less

Report

(3 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • Research Products

    (31 results)

All 2005 2004 2003 Other

All Journal Article (31 results)

  • [Journal Article] 慢性疲労症候群の診断および認知行動療法による治療2005

    • Author(s)
      岩瀬真生
    • Journal Title

      総合病院精神医学 17(1)

      Pages: 1-11

    • NAID

      10014401636

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Spatial working memory deficit correlates with disorganization symptoms and social functioning in schizophrenia2005

    • Author(s)
      Hidetoshi Takahashi
    • Journal Title

      Psychiatry and Clinical Neuroscience 59

      Pages: 453-460

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] ストレスとCFS2005

    • Author(s)
      上田素子
    • Journal Title

      Progress in-Medicine 25(5)

      Pages: 1248-1254

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 精神科からみたCFSと予後との関連2005

    • Author(s)
      岩瀬真生
    • Journal Title

      Progress in Medicine 25(5)

      Pages: 1292-1297

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Spatial working deficit correlates with disorganization symptoms and social functioning in schizophrenia2005

    • Author(s)
      Hidetoshi Takahashi et al.
    • Journal Title

      Psychiatry and Clinical Neuroscience 59

      Pages: 453-460

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Diagnostic procedure and cognitive behavioral therapy for chronic fatigue syndrome2005

    • Author(s)
      Masao Iwase et al.
    • Journal Title

      Japanese Journal of General Hospital Psychiatry 17(1)

    • NAID

      10014401636

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Psycho-social factors in chronic fatigue syndrome2005

    • Author(s)
      Motoko Ueda, Akira Shimizu
    • Journal Title

      Progress in Medicine 25(5)

      Pages: 1248-1254

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Psychiatric overview of CFS prognosis2005

    • Author(s)
      Masao Iwase et al.
    • Journal Title

      Progress in Medicine 25(5)

      Pages: 1292-1297

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 精神疲労2004

    • Author(s)
      岩瀬真生
    • Journal Title

      脳21 7(1)

      Pages: 26-31

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] クロスオーバー研究による笑いのNK活性上昇効果の検討2004

    • Author(s)
      高橋清武
    • Journal Title

      臨床精神医学 33(12)

      Pages: 1599-1607

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Reduction of serotonin transporters of patients with chronic fatigue syndrome2004

    • Author(s)
      Shigeyuki Yamamoto
    • Journal Title

      NeuroReport 15(17)

      Pages: 2571-2574

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Reduction of serotonin transporters of patients with chronic fatigue syndrome2004

    • Author(s)
      Shigeyuki Yamamoto et al.
    • Journal Title

      Neuro Report 15(17)

      Pages: 2571-2574

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Mental fatige2004

    • Author(s)
      Masao, Iwase
    • Journal Title

      Noh21 7(21)

      Pages: 26-31

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The elevation of natural killer cell activity induced by laughter in a crossover designed study2004

    • Author(s)
      Kiyotake Takahashi et al.
    • Journal Title

      Japanese Journal of Clinical Psychiatry 33(12)

      Pages: 1599-1607

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 笑いの効用と免疫作用について2003

    • Author(s)
      岩瀬真生
    • Journal Title

      東京都臨床衛生検査技師会誌 31(1)

      Pages: 6-11

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 慢性疲労症候群の精神医学的側面2003

    • Author(s)
      岩瀬真生
    • Journal Title

      医学のあゆみ 204(5)

      Pages: 392-397

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] The inappropriate smile and zygomatic muscle activity2003

    • Author(s)
      Tsukasa Azuma
    • Journal Title

      Perceptual and Motor Skills 96

      Pages: 481-491

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 精神生理学からみた笑いのメカニズム2003

    • Author(s)
      岩瀬真生
    • Journal Title

      臨床精神医学 32(8)

      Pages: 927-933

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Advanced Trail Making Test (ATMT)によるVisuospatial Working Memoryの測定-精神疾患における応用可能性について2003

    • Author(s)
      岩瀬真生
    • Journal Title

      精神医学 45(12)

      Pages: 1291-1296

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The Inappropriate smile and zygomatic muscle activity2003

    • Author(s)
      Tsukasa Azuma et al.
    • Journal Title

      Perceptual and Motor Skills 96

      Pages: 481-491

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The benefit and immunological effects of laughter2003

    • Author(s)
      Masao Iwase
    • Journal Title

      The Tokyo Journal of Medical Technology 31(1)

      Pages: 6-11

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Psychiatric aspects of chronic fatigue syndrome2003

    • Author(s)
      Masao Iwase, Akira Shimizu
    • Journal Title

      Journal of Clinical and Experimental Medicine (IGAKU NO AYUMI) 204(5)

      Pages: 392-397

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Psychophysiological view of laughter and smile2003

    • Author(s)
      Masao Iwase, Akira Shimizu
    • Journal Title

      Japanese Journal of Clinical Psychiatry 32(8)

      Pages: 927-933

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The assessment of visuospatial working memory using Advanced Trail Making Test (ATMT) in psychiatric disorders2003

    • Author(s)
      Masao Iwase et al.
    • Journal Title

      Clinical Psychiatry 45(12)

      Pages: 1291-1296

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 笑いの効用と免疫作用について2003

    • Author(s)
      岩瀬真生
    • Journal Title

      東京都臨床衛生検査技師学会誌 31(1)

      Pages: 6-11

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Advanced Trail Making Test(ATMT)によるVisuospatial Working Memoryの測定-精神疾患における応用可能性について2003

    • Author(s)
      岩瀬真生
    • Journal Title

      精神医学 45(12)

      Pages: 1291-1296

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Disturbed Holistic Processing in Autism Spectrum Disorders Verified by Two Cognitive Tasks Requiring Perception of Complex Visual Stimuli

    • Author(s)
      Takayuki Nakahachi
    • Journal Title

      Psychiatry Research In press

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Discrepancy of performance among working memory related tasks in autism spectrum disorders was caused by task characteristics except working memory which could interfere with task execution

    • Author(s)
      Takayuki Nakahachi
    • Journal Title

      Psychiatry and Clinical Neuroscience In press

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Disturbed holistic processing in autism spectrum disorders verified by two cognitive tasks requiring perception of complex visual stimuli

    • Author(s)
      Takayuki Nakahachi et al.
    • Journal Title

      Psychiatry Research (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Discrepancy of performance among working memory tasks in autism spectrum disorders was caused by task characteristics except working memory which could interfere with task execution

    • Author(s)
      Takayuki Nakahachi et al.
    • Journal Title

      Psychiatry and Clinical Neuroscience (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 精神科からみた慢性疲労症候群と予後との関連

    • Author(s)
      岩瀬真生
    • Journal Title

      Progress in Medicine In press

    • Related Report
      2004 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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