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Radiation-induced p53-independent apoptosis and radiosensitivity in human tumors

Research Project

Project/Area Number 15591257
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionGunma University

Principal Investigator

HASEGAWA Masatoshi  Gunma University, Graduate School of Medicine, Associate professor, 大学院・医学系研究科, 助教授 (50251111)

Project Period (FY) 2003 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2004: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2003: ¥2,200,000 (Direct Cost: ¥2,200,000)
Keywordsp53 / apoptosis / radiation / heavy ion beam / RBE / radiosensitivity / アポートシス / 悪性リンパ腫 / 重粒子線
Research Abstract

1.p53-dependent and p53-independent apoptosis induced by radiation, and RBE of carbon ion beams :
The aim of this study is to evaluate the relationships between p53 status and radiation-induced apoptosis. Male mice (C57BL/6) and human tumors transplanted to nude mice were irradiated with 200 kV X-rays or carbon ion beams (290MeV/u, 6cm SOBP,NIRS). The incidence of apoptosis of radiosensitive normal tissues and tumor cells having wild-type p53 increased markedly following irradiation (p53-dependent apoptosis), although the incidence of apoptosis of radioresistant tumor cells having mutant-type p53 increased slightly (p53-ihdependent apoptosis). The RBE values of carbon ion beams evaluated by apoptotic cell death were suggested to be more than 4 for a radioresistant tumor having mutant-type p53, about 3 for radiosensitive tumors having wild-type p53, and 1.5-2.1 for radiosensitive normal tissues having wild-type p53 (spermoatogonia of the testis, crypt cells of the small intestine, and neuronal cells of the hippocampus). Furthermore, the RBE values evaluated by the chronic changes of the testis were 1.2-1.6. These results indicated that the heavy ion beams induce more p53-independet apoptosis than X-rays, and the differences in the RBE values between tumors and normal tissues might contribute to a favorable therapeutic ratio in radiotherapy.
2.Radiation therapy for radiosensitive human tumors :
Treatment results of radiation therapy for radiosensitive human tumors (malignant lymphoma, germinoma, etc.) were analyzed, and the efficacy of radiation was reevaluated.

Report

(3 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • Research Products

    (21 results)

All 2005 2004 2003 Other

All Journal Article (17 results) Publications (4 results)

  • [Journal Article] 頭頸部初発低悪性度リンパ腫の放射線治療2005

    • Author(s)
      長谷川正俊, 斉藤淳一, 松田真里子, 鈴木義行, 石川仁, 桜井英幸 他
    • Journal Title

      頭頸部癌 31・1(in press)

    • NAID

      10015527571

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 粒子線治療とp532004

    • Author(s)
      長谷川正俊
    • Journal Title

      癌の臨床 50

      Pages: 1103-1106

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Expression of hypoxic-inducible factor 1alpha predicts metastasis-free survival after radiation therapy alone in stage IIIB cervical squamous cell carcinoma2004

    • Author(s)
      石川仁
    • Journal Title

      Int J Radiat Oncol Biol Phys 60

      Pages: 513-521

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] CT-fluoroscopy guided interstitial brachytherapy with image-based treatment planning for unresectable localy recurrent recta carcinoma2004

    • Author(s)
      桜井英幸
    • Journal Title

      Brachytherapy 3

      Pages: 222-230

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Primary central nervous system lymphoma in Japan 1995-1999:changes from the preceding 10 years2004

    • Author(s)
      芝本雄太
    • Journal Title

      J Cancer Res Clin Oncol 130

      Pages: 351-356

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Particle radiation therapy and p53.2004

    • Author(s)
      Hasegawa M, Nojima K, Ohno T, Ishikawa H, Suzuki Y, Wakatsuki M, Imai R, Kato S, Nakano T
    • Journal Title

      Jpn J Cancer Clin 50-13

      Pages: 1103-1106

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Expression of hypoxic-inducible factor 1 alpha predicts metastasis-free survival after radiation therapy alone in stage IIIB cervical squamous cell carcinoma.2004

    • Author(s)
      Ishikawa H, Sakurai H, Hasegawa M, Mitsuhashi N, Takahashi M, Masuda N, Nakajima M, Kitamoto Y, Saitoh J, Nakano T
    • Journal Title

      Int J Radiat Oncol Biol Phys 60-2

      Pages: 513-521

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] CT-fluoroscopy guided interstitial brachytherapy with image-based treatment planning for unresectable locally recurrent rectal carcinoma.2004

    • Author(s)
      Sakurai H, Mitsuhashi N, Harashima K, Muramatsu H, Ishikawa H, Kitamoto Y, Suzuki Y, Saitoh JI, Nonaka T, Akimoto T, Nakayama Y, Hasegawa M, Nakano T
    • Journal Title

      Brachytherapy 3-4

      Pages: 222-230

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Primary central nervous system lymphoma in Japan 1995-1999 : changes from the preceding 10years.2004

    • Author(s)
      Shibamoto Y, Tsuchida E, Seki K, Oya N, Hasegawa M, Toda Y, Takemoto Y, Sumi M, Hiratsuka J, Oguchi M, Hosono M, Yasuda S, Sougawa M, Kakutoh Y, Hayabuchi N
    • Journal Title

      J Cancer Res Clin Oncol 130-6

      Pages: 351-356

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Expression of hypoxic-inducible factor 1alpha predicts metastasis-free survival after radiation therapy alone in stage IIIB cervical squamous cell carcinoma2004

    • Author(s)
      Ishikawa H, Sakurai H, Hasegawa M, Mitsuhashi N, Takahashi M, et al.
    • Journal Title

      Int J Radiat Oncol Biol Phys 60・2

      Pages: 513-521

    • Related Report
      2004 Annual Research Report
  • [Journal Article] CT-fluoroscopy guided interstitial brachytherapy with image-based treatment planning for unresectable locally recurrent rectal carcinoma2004

    • Author(s)
      Sakurai H, Mitsuhashi N, Harashima K, Muramatsu H, Hasegawa M, et al.
    • Journal Title

      Brachytherapy 3・4

      Pages: 222-230

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Primary central nervous system lymphoma in Japan 1995-1999 : changes from the preceding 10 years2004

    • Author(s)
      Shibamoto Y, Tsuchida E, Seki K, Oya N, Hasegawa M, Toda Y, et al.
    • Journal Title

      J Cancer Res Clin Oncol 130・6

      Pages: 351-356

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 粒子線治療とp532004

    • Author(s)
      長谷川正俊, 野島久美恵, 大野達也, 石川仁, 鈴木義行, 若月優 他
    • Journal Title

      癌の臨床 50・13

      Pages: 1103-1106

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Treatment results of radiotherapy for malignant lymphoma of the orbit and histopathologic review according to the WHO classification2003

    • Author(s)
      長谷川正俊
    • Journal Title

      Int J Radiat Oncol Biol Phys 57

      Pages: 172-176

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Comparable outcomes of radiation therapy without high-dose methotrexate for patients with primary central nervous system lymphoma2003

    • Author(s)
      石川仁
    • Journal Title

      Jpn J Clin Oncol 33

      Pages: 443-449

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Treatment results of radiotherapy for malignant lymphoma of the orbit and histopathologic review according to the WHO classification.2003

    • Author(s)
      Hasegawa M, Kojima M, Shioya M, Tamaki Y, Saitoh J, Sakurai H, Kitamoto Y, Suzuki Y, Niibe H, Nakano T
    • Journal Title

      Int J Radiat Oncol Biol Phys 57-1

      Pages: 172-176

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Comparable outcomes of radiation therapy without high-dose methotrexate for patients with primary central nervous system lymphoma.2003

    • Author(s)
      Ishikawa H, Hasegawa M, Tamaki Y, Hayakawa K, Akimoto T, Sakurai H, Mitsuhashi N, Niibe H, Tamura M, Nakano T
    • Journal Title

      Jpn J Clin Oncol 33-9

      Pages: 443-449

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Publications] Hasegawa M: "Treatment results of radiotherapy for malignant lymphoma of the orbit and histopathologic review according to the WHO classification"Int J Radiat Oncol Biol Phys. 57・1. 172-176 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ishikawa H: "Comparable Outcomes of Radiation Therapy without High-dose Methotrexate for Patients with Primary Central Nervous System Lymphoma"Jpn J Clin Oncol. 33・9. 443-449 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kitamoto Y: "Mucosa-associated lymphoid tissue lymphoma of the esophagus : a case report"J Clin Gastroenterol. 36・5. 414-416 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 斉藤淳一: "低酸素細胞マーカーを用いた腫瘍内低酸素の評価"癌の臨床. 49・12. 1555-1559 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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