| Project/Area Number |
15591258
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Chiba University |
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Principal Investigator |
UNO Takashi Chiba Univ., Graduate School of Med., Associate Prof., 大学院・医学研究院, 助教授 (30302540)
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| Co-Investigator(Kenkyū-buntansha) |
ITO Hisao Chiba Univ., Graduate School of Med., Prof., 大学院・医学研究院, 教授 (20095574)
KAWATA Tetsuya Chiba Univ., Graduate School of Med., Assistant Prof., 大学院・医学研究院, 講師 (60234077)
UCHIDA Yoshitaka Chiba Univ.Hospital, Assistant Prof., 医学部附属病院, 講師 (30261902)
ISOBE Kouichi Chiba Univ.Hospital, Research Assistant, 医学部附属病院, 助手 (80334184)
YAMAMOTO Seiji Chiba Univ.Hospital, Research Assistant, 医学部附属病院, 助手 (40302567)
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| Project Period (FY) |
2003 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2004: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2003: ¥2,300,000 (Direct Cost: ¥2,300,000)
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| Keywords | Central nervous system / Heavy iron / Sexual function / Hypothalamus / Copulatory behavior |
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| Research Abstract |
The effect of heavy-ion irradiation to the brain on sexual behavior is not yet known. The present study was designed to determine whether irradiation (carbon particles,290 MeV/nucleon, Mono peak 15~ 120 Gy,irradiation field 5-mm^3 in hypothalamus) to rat's hypothalamus modifies copulatory behavior of male rats. We planned to estimate the short-term effects of carbon-irradiation on copulatory behavior using a relatively high doses, and observation of sexual behavior was conducted for 30 min after 1,2 or 3 months following irradiation.
Results obtained are as follows :
1.At dosages of 15Gy,30Gy,45Gy and 60Gy, these were no changes in copulatory behavior after 1 month following irradiation ; however, intromission and ejaculation were found to decrease after 3-month follow-up in rats exposed to 60 Gy.
2.At higher doses such as 90Gy,120Gy, the number of mounting, intromission (120Gy alone) and ejaculation (90Gy,120Gy) were decreased.
From the experimental results described above, it may be possible to determine that carbon beam irradiation to hypothalamus does not inhibit the activity of copulatory behavior for a short period after irradiation. Further experiments that need long-term follow-up after irradiation must be necessary to determine the chronic effects of heavy ions on the copulatory behavior.
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