| Project/Area Number |
15591259
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
ABE Osamu The University of Tokyo, Faculty of Medicine, Lecturer, 医学部附属病院, 講師 (50302716)
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| Co-Investigator(Kenkyū-buntansha) |
YAMADA Haruyasu The University of Tokyo, Faculty of Medicine, Research Associate, 医学部附属病院, 助手 (70359610)
KASAI Kiyoto The University of Tokyo, Faculty of Medicine, Lecturer, 医学部附属病院, 講師 (80322056)
AOKI Shigeki The University of Tokyo, Faculty of Medicine, Associate Professor, 医学部附属病院, 助教授 (80222470)
OHTOMO Kuni The University of Tokyo, Faculty of Medicine, Professor, 医学部附属病院, 教授 (80126010)
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| Project Period (FY) |
2003 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2005: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2004: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2003: ¥2,100,000 (Direct Cost: ¥2,100,000)
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| Keywords | magnetic resonance imaging / diffusion tensor / amyotrophic lateral sclerosis / normal agin / posttraumatic stress disorder / statistical parametric mapping / diffusion tensor tractography / magnetic resonance imaging / diffusion tensor / amyotrophic lateral sclerosis / posttraumatic stress disorder / statisical parametric mapping / diffusion tensor tractography / 筋萎縮性側策硬化症 / SPM99 |
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| Research Abstract |
Recent functional neuroimaging work has suggested that interregional functional connectivity between the anterior cingulate cortex (ACC), other limbic, and prefrontal regions may be involved in the pathophysiology of posttraumatic stress disorder (PTSD). However, less attention has been paid to the white matter network. Voxel-based analysis enables an exploration of morphological or functional changes throughout the entire brain. Here we undertook the first application of this technology to diffusion tensor data in patients with PTSD. Participants were 9 victims of the Tokyo subway sarin attack with PTSD and 16 matched victims of the same traumatic event without PTSD. The voxel-based analysis showed a significant fractional anisotropy increase in the left anterior cingulum, subjacent to the left ACC gray matter where we previously found volume decrement, in PTSD subjects. Moreover, the severity was positively, but not significantly associated with the fractional anisotropy of the left anterior cingulum in the victims with PTSD, using the region of interest defined in the native space with the inverse normalization technique. The present study demonstrated further evidence of abnormalities of both the ACC, a structure which is pivotally involved in attention, emotional regulation, and fear conditioning, and of subjacent white matter in the pathology of PTSD.
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