Application of inhibitor of nitric oxide synthesis in hyperglycemic ischemic rats: evaluation of the administration time of the drug using diffusion-weighted MRI
| Project/Area Number |
15591266
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Mie University |
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Principal Investigator |
MAEDA Masayuki Mie University, School of Medicine, Assistant Professor, 医学部附属病院, 講師 (70219278)
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| Co-Investigator(Kenkyū-buntansha) |
SAKUMA Hajime Mie University, School of Medicine, Associated Professor, 医学部附属病院, 助教授 (60205797)
KAN Takeda Mie University, School of Medicine, Professor, 大学院医学系研究科, 教授 (70106988)
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| Project Period (FY) |
2003 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2006: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2005: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2004: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2003: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | Cerebral Ischemia / Hyperglycemia / Free radical inhibitor / Diffusion-weighted MRI / 脳虚血 / 拡散MRI |
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| Research Abstract |
In this study, we investigated the effect of administration time of N-nitro-L-arginine methyl ester (L-NAME), an NO-synthase inhibitor, in hyperglycemic rats of transient focal cerebral ischemia (1 h occlusion of the middle cerebral artery and reperfusion). Rats received single intraperitoneal administration of L-NAME 3 mg/kg, given immediately, 30 min, or 1 h after ischemia onset. The ischemic volume of the brain was measured using diffusion-weighted MRI (b=2000 s/mm^2) at 2h, 6 h, and 24 h after ischemia. L-NAME reduced the infarct volume by 32% at 2 h (p< 0.05), 21% at 6 h (p<0.05), and 12% at 24 h (p>0.05) compared to placebo (saline) administration when given immediately after ischemia, but it had no neuroprotective activity when given 30 min and 1 h after ischemia. L-NAME might be neuroprotective in a hyperglycemic model of transient ischemia
when given immediately after ischemia.
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Report
(5 results)
Research Products
(39 results)
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[Journal Article] Reversible splenial lesion with restricted diffusion in a wide spectrum of diseases and conditions2006
Author(s)
M.Maeda, H.Tsukahara, H.Terada, S.Nakaji, H.Nakamura, H.Oba, O.Igarashi, K.Arasaki, T.Machida, K.Takeda, J.I.Takanashi
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Journal Title
Journal of Neuroradiology 33巻
Pages: 229-236
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[Journal Article] Clinically mild encephalitis/encephalopathy with a reversible splenial lesion2004
Author(s)
Tada H, Takanashi J, Barkovich AJ, Oba H, Maeda M, Tsukahara H, Suzuki M, Yamamoto T, Shimono T, Ichiyama T, Taoka T, Sohma 0, Yoshikawa H, Kohno Y.
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Journal Title
Neurology 63
Pages: 1854-1858
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