• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Prediction of aggressiveness of prostate cancer using MR spectroscopy at ultra-high magnetic field

Research Project

Project/Area Number 15591275
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionKobe University

Principal Investigator

KAJI Yasushi  Kobe University, Hospital, Assistant Professor, 医学部附属病院, 講師 (10273947)

Co-Investigator(Kenkyū-buntansha) SUGIMURA Kazuro  Kobe University, Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (00136384)
FUJII Masahiko  Kobe University, Hospital, Associate Professor, 医学部附属病院, 助教授 (00228959)
KAMIDONO Sadawo  Kobe University, Graduate School of Medicine, Professor(director), 大学院・医学系研究科, 教授(理事) (30030935)
KURODA Kagayaki  Tokai University, School of Information Technology and Electronics, Associate Professor, 電子情報学部, 助教授 (70205243)
Project Period (FY) 2003 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2004: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2003: ¥1,900,000 (Direct Cost: ¥1,900,000)
Keywordsprostate cancer / ultra-high magnetic field / MR spectroscopy / MR spectroscopy / MRI
Research Abstract

In 2003, 5 patients with biopsy proved prostate cancer were included in this study. MR images and MR spectra were obtained using 3 tesla MR unit. In 4 of 5 patients, spectra could not be evaluated because of poor quality due to post-biopsy prostate hemorrhage.
Elimination of rectal gas and prostate hemorrhage was needed to keep magnetic field homogeneity. MR examination was performed before prostate biopsy, and using a purgative the day before the MR examination in 2004 study.
High quality spectra were obtained in 25 of 51 patients (50%). It was presumed that one of the reasons of low successful rate was inhomogeneous radiofrequency (RF) excitation of whole prostate. In 25 patients, the (choline + creatine) / citrate peak area ratio (CC/C) was calculated after spectroscopic acquisition. The mean CC/C was 1.94 in peripheral zone (PZ) cancer, and 0.46 in healthy PZ (p<0.0001). In transition zone (TZ), the mean CC/C was 1.84 in cancer, and 1.03 in healthy TZ.
The limitation of this study was low successful examination rate, but the spectral quality in patient with successful RF excitation was superior to usual spectrum at 1.5 tesla. When the RF excitation method is improved completely, significantly important metabolite information is produced using ultra-high MR unit.

Report

(3 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report

URL: 

Published: 2003-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi