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Evaluation of regional blood flow dynamics of the liver by hepatic blood flow imaging using ultrafast MR imaging

Research Project

Project/Area Number 15591278
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionYamaguchi University

Principal Investigator

ITO Katsuyoshi  Yamaguchi University, Hospital, Radiology, Assistant Professor, 医学部附属病院, 講師 (00274168)

Co-Investigator(Kenkyū-buntansha) FUJITA Takeshi  Yamaguchi University, School of Medicine, Research Associate, 医学部, 助手 (50335733)
MATSUNAGA Naofumi  Yamaguchi University, School of Medicine, Professor, 医学部, 教授 (40157334)
Project Period (FY) 2003 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2004: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2003: ¥2,800,000 (Direct Cost: ¥2,800,000)
KeywordstrueFISP / Portal flow / Tagging pulse / Whirled flow / Corona enhancement / Perfusion / Subtraction / 門脈 / 血流分布 / 門脈内渦状流 / 肝血流パフュージョン画像 / rapid central washout
Research Abstract

TrueFISP MR imaging of the portal flow using a selective inversion recovery tagging pulse was performed to evaluate the intraportal venous flow distribution from the superior mesenteric vein and the splenic vein. Tagged blood flow into the portal vein was shown as areas of decreased signal intensity in the portal vein. Especially, trueFISP images obtained perpendicular to the portal vein allows three-dimensional observation of intraportal venous flow distribution. In the study of normal subjects, the blood flow from the superior mesenteric vein and the splenic vein formed streamlined flow in the half of the subjects, but it showed whirled flow in the portal vein in the remaining subjects on the trueFISP MR images obtained perpendicular to the portal vein. TrueFISP MR imaging perpendicular to the portal vein achieved high spatial and high contrast resolution imaging and allowed detailed evaluation of the intraportal venous flow distribution. In patients with cirrhosis or chronic hepatit … More is, the whirled flow in the portal vein was often observed probably due to the increased splenic venous flow. The whirled flow may also be associated with the anatomical variations of confluent patterns between the splenic vein and the superior mesenteric vein.
In evaluating the influence of fasting and food intake for the portal flow dynamics, we revealed that the portal vein was predominantly perfused by the splenic venous flow before meal while it was predominantly perfused by the superior mesenteric venous flow after meal. Additionally, the superior mesenteric venous flow dramatically increased after meal compared with the fasting state while the splenic venous flow decreased in 41%, increased in 31% and showed no change in 28% of the subjects.
In hepatic perfusion MR imaging using multi-arterial and multi-portal phase contrast-enhanced dynamic MR imaging of the whole liver, we found useful appearances of hemodynamic patterns of focal hepatic lesions. Rapid central washout following the early enhancement of the lesion and coronal enhancement surrounding the lesion are highly specific and diagnostic findings of small hypervascular HCCs if present. Hypervascular pseudolesions tend to show prolonged enhancement during the arterial phase, compared with hypervascular HCCs. Subtraction images obtained from multi-arterial phase images were helpful for the detection of faint enhancement of the fecal hepatic lesions. Less

Report

(3 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • Research Products

    (13 results)

All 2004 2003 Other

All Journal Article (8 results) Book (2 results) Publications (3 results)

  • [Journal Article] Multiarterial phase dynamic MRI of small early enhancing hepatic lesions in cirrhosis or chronic hepatitis : differentiating between hypervascular hepatocellular carcinomas and pseudolesions2004

    • Author(s)
      Ito K
    • Journal Title

      AIR 183(3)

      Pages: 699-705

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Multiarterial phase dynamic MRI of small early enhancing hepatic lesions in cirrhosis or chronic hepatitis : differentiating between hypervascular hepatocellular carcinomas and pseudolesions2004

    • Author(s)
      Ito K
    • Journal Title

      AJR 183(3)

      Pages: 699-705

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] 肝臓:さらに高速化したダイナミック撮像のテクニック2003

    • Author(s)
      伊藤克能
    • Journal Title

      INNERVISION 18(9)

      Pages: 30-33

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 肝細胞癌におけるSubtractionを用いたmulti-arterial phase dynamic MR像の検討2003

    • Author(s)
      佐々木克己
    • Journal Title

      日本磁気共鳴医学会雑誌 23

      Pages: 79-79

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 選択的IOタギングパルスを用いた脂肪制御trueFISPによる門脈内血流分布の評価:門脈正接像による検討2003

    • Author(s)
      清水文め
    • Journal Title

      日本磁気共鳴医学会雑誌 23

      Pages: 138-138

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Liver : techniques for fast dynamic MR imaging2003

    • Author(s)
      Katsuyoshi Ito
    • Journal Title

      INNERVISION 18(9)

      Pages: 30-33

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Multi-arterial phase dynamic MR imaging with subtraction techniques for hepatocellular carcinomas2003

    • Author(s)
      Katsumi Sasaki
    • Journal Title

      Jpn J of Magnetic Resonance Imaging 23

      Pages: 79-79

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Intraportal venous flow distribution assessed by fat suppressed trueFISP MR imaging with a selective IR tagging pulse : Evaluation with images obtained perpendicular to the portal vein2003

    • Author(s)
      Ayame Shimizu
    • Journal Title

      Jpn J of Magnetic Resonance Imaging 23

      Pages: 138-138

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] 肝の最新MRI(谷本伸弘編)2004

    • Author(s)
      伊藤克能
    • Total Pages
      195
    • Publisher
      金原出版株式会社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] 肝の最新MRI(谷本伸弘,編)2004

    • Author(s)
      伊東克能
    • Total Pages
      195
    • Publisher
      金原出版株式会社
    • Related Report
      2004 Annual Research Report
  • [Publications] 伊藤克能: "肝臓:さらに高速化したダイナミック撮像のテクニック"INNERVISION. 18(9). 30-33 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 佐々木克己: "肝細胞癌におけるSubtractionを用いたmulti-arterial phase dynamic MR像の検討"日本磁気共鳴医学会雑誌. 23. 79-79 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 清水文め: "選択的IOタギングパルスを用いた脂肪制御trueFISPによる門脈内血流分布の評価:門脈正接像による検討"日本磁気共鳴医学会雑誌. 23. 138-138 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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