| Project/Area Number |
15591282
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kyushu University |
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Principal Investigator |
KENGO Yoshimitsu Kyushu University, University Hospital, Assistant Professor, 大学病院, 講師 (20274467)
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| Co-Investigator(Kenkyū-buntansha) |
HONDA Hiroshi Kyushu University, Graduate School of Medical Sciences, Professor, 大学院・医学研究院, 教授 (90145433)
IRIE Hiroyuki Kyushu University, University Hospital, Assistant Professor, 大学病院, 講師 (50284493)
TAJIMA Tsuyoshi Kyushu University, University Hospital, Research Associate, 大学病院, 助手 (50346798)
ASAYAMA Yoshiki Kyushu University, University Hospital, Research Associate, 大学病院, 助手 (40380414)
HIRAKAWA Masakazu Kyushu University, Graduate School of Medical Sciences, Contracted Research Associate, 大学院・医学研究院, 学術研究員 (20380454)
西江 昭弘 九州大学, 医学研究院, 学術研究員
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| Project Period (FY) |
2003 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2005: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 2004: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2003: ¥2,500,000 (Direct Cost: ¥2,500,000)
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| Keywords | fatty liver / MR / chemical shift / MR spectroscopy / living-related liver transplantation / 化学シフト画像 |
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| Research Abstract |
<Purpose>To assess the degree of fatty liver for candidates of donor of living related liver transplantation (LRLT) using chemical shift MR imaging (CSI) and plain CT
<Materials and Methods>Between 2000 and 2004, 18 donors for LRLT who were suspected to have fatty liver were examined with CSI. 13 of them also underwent plain CT. 1.5 T clinical MR unit and 1 4-detector-row multislice CT were used. CSI were obtained with 2DFALSH sequence with the parameters as follows ; TR/TE1 & TE2/FA=100 msec/2.3 & 4.1msec/70°. As for the indices of fatty liver, MR index (MRIn)=(SIip-SIop)/SIip, CT index (CTIn)=(DL-DSp) were defined, where SIip/op indicate signal intensity of the liver on in-phase and out-of phase images, and DL/Sp indicates CT values of liver and spleen. Percutaneous biopsy of the liver at the right anterior segment was performed within 10 days from MR or CT examinations. Histopathological grades (X=1-5) of fatty liver was correlated to MRIn and CTIn.
<Results>Both MRIn and CTIn showed good correlation the histopathological grades (MRI=-0.126+0.071X : R2=0.695, p<.0001、CTI=25.8-8.03 X : R2=0.746, p<.0001). However, when cases were limited to mildly fatty liver (less than 30% histopathologically), MRIn showed significantly better correlation than CTIn (p<0.001).
<Conclusion>As non-invasive methods to evaluate fatty liver in LRLT donor patients, both MR and CT provided useful information ; the former was shown to be useful particularly for low grade fatty liver, and the latter for high grade fatty liver. MR and CT can be used complementarily for evaluation of fatty liver in LRLT donor patients
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