| Project/Area Number |
15591298
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Iwate Medical University |
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Principal Investigator |
SASA Makoto Iwate Medical University, Dpartment of Radiology, Assistant professor, 医学部, 講師 (80205864)
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| Co-Investigator(Kenkyū-buntansha) |
OIKAWA Hirobumi Iwate Medical University, Departinent of Radiology, Assisntant, 医学部, 助手 (10337157)
INOUE Takashi Iwate MedicalUniversity, epartinent of Neurosurgery, Assistant professor, 医学部, 講師 (70326651)
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| Project Period (FY) |
2003 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2004: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2003: ¥2,300,000 (Direct Cost: ¥2,300,000)
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| Keywords | Magnetic resonance imaging / High field / Multidetector-row CT / Subthalamic nucleus / Ventral thalamus / Stereotaxic neurosurgery / Three-dimensional imaging / Neuromelanin |
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| Research Abstract |
We tried to establish three-dimensional (3D) visualization and measurement techniques of minute deep gray matter structures, such as the subthalamic nucleus (STN), for preoperative assessment of stereotaxic neurosurgery using high-field 3 Tesla (3T) MRI and multidetector-row CT (MDCT).
We developed myelin-density weighted 3D short inversion-time inversion recovery (STIR) technique and neuromelanin weighted fast spin echo technique at 3T. Using these techniques, we can successfully depict myelin-dense STN and surrounding small structures, fields of Forel and zona incerta, as well as neuromelanin-containing dopaminergic neurons in the substantia nigra pars compacta and noraderenergic neurons in the locus ceruleus directly. By newly developed 3D quantum denoising techniques, the low-contrast resolution of MDCT volume data was dramatically improved so that 3D structure of the deep gray matters can be clearly identified. Using a hyperplanar reconstruction (HPR) technique, which can allow us 3D gray scale expression in any curved surfaces and planes, we can visualize and measure STN and related structures from 3T MRI or MDCT volume data sets.
Myelin-density weighted imaging, neuromelanin imaging, noise-removed MDCT imaging with HPR display can help us measuring targets precisely for planning of stereotaxic neurosurgery.
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