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Hybrid treatment of deep venous thrombosis : Local fibrinolytic therapy, mechanical fragmentation, and clot aspiration.

Research Project

Project/Area Number 15591305
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionNippon Medical School

Principal Investigator

TAJIMA Hiroyuki  Nippon Medical School, Medicine, Professor, 医学部, 教授 (00188244)

Project Period (FY) 2003 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 2005: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2004: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2003: ¥1,900,000 (Direct Cost: ¥1,900,000)
Keywordsdeep venous thrombosis / interventional radiology / thrombolysis / thrombectomy / aspiration / pulinonary thromboembolism / I.V.R.
Research Abstract

Deep venous thrombosis is a common sourse of morbidity and mortality even in Japan. Complications include pulmonary thromboembolism and chronic post thrombotic syndrome. The standard treatment consists of medical management with anticoagulation, but anticoagulation alone does not always restore venous patency and many patients are left with venous outflow obstruction and valvular inconpetence. Aggressive endovascular techniques for managing deep venous thrombosis have evolved as a result. Catheter directed thrombolysis was the first such procedure with demonstrated efficacy, but its acceptance has been limited by perceived risks, time to lysis, and cost. As a result, alternative measures have evolved including percutaneous interventional procedure.
After the experimental research, I started the clinical study of these interventional procedures.
Objective : To evaluate the efficacy and safety of a hybrid treatment for severe deep venous thrombosis by combining local thrombolysis, mechanic … More al fragmentation, and clot aspiration.
Subjects and methods : 45 patients with deep venous thrombosis were treated with hybrid interventional procedures. After insertion of a temporary vena cava filter, thrombo-aspiration with a PTCA guiding catheter and/or mechanical thrombectomy with OASIS or modified rotating pigtail catheter system were performed. Additional balloon PTA/stenting and continuous local urokinase therapy was performed, if needed. The primary endpoint was venographic findings of thrombus extraction. Systemic thrombolysis and anticoagration therapy followed.
Results : Trans-femoral interventional radiological therapy was achieved in 42 patients. Approach was ipsilateral : 22, contralateral : 20. Interventional techniques were as followed : manual clot aspiration 37, OASIS thrombectomy 13, mechanical thrombus fragmentation using a modified pigtail catheter 3, balloon PTA 3, stenting 4, and continuous local thrombolysis 16. Successful recanalization was achieved in 37 out of 42 patients. A temporary vena caval filter was easily removed 9.2 days after the insersion in 37 patients. Complications : haemothorax 1, retroperitoneal hematoma 1.
Conclusion : Hybrid treatments are a therapeutic option in patients presenting deep venous thrombosis. Less

Report

(4 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (18 results)

All 2006 2005 2004 Other

All Journal Article (14 results) Publications (4 results)

  • [Journal Article] 静脈血栓塞栓症 : 成因・診断から治療・予防まで.序説.2006

    • Author(s)
      田島廣之
    • Journal Title

      臨床画像 22・3

      Pages: 245-245

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 日常診療のコツ+工夫.深部静脈血栓症のIVR.2006

    • Author(s)
      田島廣之, ほか
    • Journal Title

      Radiology Frontier 9・1

      Pages: 55-57

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] 血管系の良性疾患のIVR.深部静脈血栓症の治療.2006

    • Author(s)
      田島廣之, ほか
    • Journal Title

      Radiology Frontier 9・2

      Pages: 91-94

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Venous thrombo-embolism : Genesis, diagnosis, therapy, and protection2006

    • Author(s)
      Hiroyuki Tajima
    • Journal Title

      Clinical Imagiology 22(3)

      Pages: 245-245

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] IVR for deep venous thrombosis.2006

    • Author(s)
      Hiroyuki Tajima, et al.
    • Journal Title

      Radiology Frontier 9(1)

      Pages: 55-57

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] IVR for benign vascular dideases. Interventional therapy of deep venous thrombosis.2006

    • Author(s)
      Hiroyuki Tajima, et al.
    • Journal Title

      Radiology Frontier 9(2)

      Pages: 91-94

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 静脈血栓塞栓症:成因・診断から治療・予防まで.序説.2006

    • Author(s)
      田島廣之
    • Journal Title

      臨床画像 22・3

      Pages: 245-245

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 血管系の良性疾患のIVR.深部静脈血栓症の治療2006

    • Author(s)
      田島廣之, ほか
    • Journal Title

      Radiology Frontier 9・2(印刷中)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 肺塞栓症、深部静脈血栓症の診断2005

    • Author(s)
      田島廣之, ほか
    • Journal Title

      関節外科.4月増刊号 24

      Pages: 26-33

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Diagnosis of pulmonary thrombo-embolism and deep venous thrombosis.2005

    • Author(s)
      Hiroyuki tajima, et al.
    • Journal Title

      J of Joint Surgery 24

      Pages: 26-33

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 深部静脈血栓症のIVR治療2004

    • Author(s)
      田島廣之, ほか
    • Journal Title

      日本血管造影IVR学会雑誌 19

      Pages: 27-31

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 静脈血栓症のIVR : 最新情報.2004

    • Author(s)
      田島廣之, ほか
    • Journal Title

      臨床画像 20

      Pages: 99-99

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] IVR treatment of deep venous thrombosis.2004

    • Author(s)
      Hiroyuki Tajima, et al.
    • Journal Title

      Jpn J Intervent Radiol 19

      Pages: 27-31

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] IVR for venous thromboembolism.2004

    • Author(s)
      Hiroyuki Tajima
    • Journal Title

      Clinical Imagiology 20

      Pages: 99-99

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Publications] 田島 廣之 他: "深部静脈血栓塞のIVR治療-大腿静脈ブローチ-"日本血管造影・インターベンショナルラジオロジー学会雑誌. 19・1. 10-14 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 田島 廣之: "静脈血栓症のIVR:最近情報"臨床画像. 20・1. 99 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Hiroyuki Tajima, et al.: "Successful Interventional Treatment of Acute Internal Jugular Vein Thrombosis"A.J.R.(American Journal of Roentgenology). 182・2. 467-469 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 田島廣之 他: "改訂版,救急疾患のIVR,手技の実際とポイント[分担]"深部静脈血栓症-1.-. 174 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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