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Changes in cerebral blood flow and cerebral oxygen metabolism during neural activation measured by positron emission tomography : comparison with changes in blood oxygeration level-dependent contrast measured by functional magnetic resonance imaging

Research Project

Project/Area Number 15591314
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionTOHOKU UNIVERSITY

Principal Investigator

ITO Hiroshi  TOHOKU UNIVERSITY, HOSPITAL, LECTURER, 病院, 講師 (20360357)

Co-Investigator(Kenkyū-buntansha) KANNO Iwao  AKITA RESEARCH INSTITUTE OF BRAIN AND BLOOD VESSELS, SENIOR RESEARCHER, 放射線医学研究部, 副研究局長 (10360356)
IBARAKI Masanobu  AKITA RESEARCH INSTITUTE OF BRAIN AND BLOOD VESSELS, RESEARCHER, 放射線医学研究部, 研究員 (40360359)
GOTO Ryoi  TOHOKU UNIVERSITY, HOSPITAL, RESEARCH ASSOCIATE, 病院・助手 (70302221)
Project Period (FY) 2003 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 2004: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2003: ¥1,700,000 (Direct Cost: ¥1,700,000)
KeywordsfMRI / BOLD / PET / CBF / CMRO2 / OEF
Research Abstract

The discrepancy between the increases in cerebral blood flow (CBF) and cerebral metabolic rate of oxygen (CMRO2) during neural activation causes an increase in venous blood oxygenation and, therefore, a decrease in paramagnetic deoxyhemoglobin concentration in venous blood. This can be detected by functional magnetic resonance imaging (fMRI) as blood oxygenation level-dependent(BOLD) contrast. However, the relation between cerebral oxygen extraction fraction (OEF), that corresponds to the ratio of CMRO2 to CBF, and BOLD contrast duaring neural activation has not been shown directly in human subjects. In the present study, changes in the OEF and in the BOLD signal during neural activation were measured by both positron emission tomography (PET) and fMRI in the same human subjects. PET studies were performed in each of seven healthy men at rest (baseline) and during parformance of a right hand motor task fMRI studies were then performed to measure the BOLD signal under the two conditions. Regions of interest (ROIs) were defined on all CBF, cerebral blood volume (CBV), OEF, CMRO2, and BOLD images for areas showing statistically significant changes in CBF. Significant relatire hyperperfusion indicating neural activation during the motor task activity was observed in the left precentral gyrus, left superior frontal gyrus, right precentral gyrus, right cingulate gyrus, and right cerebellum. Significant relative hypoperfusion indicating neural deactivations during the motor task activity was observed in the left anterior part of cinglate gyrus and right occipital cuneus. A significant positive correlation was observed between changes in the CBF and the BOLD signal, and a significant negative correlation was observed between changes in the OEF and the BOLD signal for all ROIs. This supports the assumption on which BOLD contrast studies are based, that the discrepancy between increases in CBF and CMRO2 during neural activation causes an increase in venous blood oxygenation.

Report

(3 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • Research Products

    (16 results)

All 2005 2004 2003 Other

All Journal Article (12 results) Publications (4 results)

  • [Journal Article] Changes in Cerebral Blood Flow and Cerebral Oxygen Metabolism During Neural Activation Measured by Positron Emission Tomography : Comparison with Blood Oxygenation Level-Dependent Contrast Measured by Functional Magnetic Resonance Imaging2005

    • Author(s)
      Ito H
    • Journal Title

      J Cerebral Blood Flow and Metabolism 25(印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Changes in the Arterial Fraction of Human Cerebral Blood Volume During Hypercapnia and Hypocapnia Measured by Positron Emission Tomography2005

    • Author(s)
      Ito H
    • Journal Title

      J Cerebral Blood Flow and Metabolism 25(印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Changes in Cerebral Blood Flow and Cerebral Oxygen Metabolism During Neural Activation Measured by Positron Emission Tomography : Comparison with Blood Oxygenation Level-Dependent Contrast Measured by Functional Magnetic Resonance Imaging2005

    • Author(s)
      Ito H
    • Journal Title

      J Cerebral Blood Flow and Metabolism 25(IN PRESS)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Changes in the Arterial Fraction of Human Cerebral Blood Volume During Hypercapnia and Hypocapnia Measured by Positron Emission Tomography2005

    • Author(s)
      Ito H
    • Journal Title

      J Cerebral Blood Flow and Metabolism 25(IN PRESS)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Error analysis of measured cerebral vascular response to acetazolamide stress by I-123-IMP autoradiographic method with single photon emission computed tomography : errors due to distribution volume of I-123-IMP2004

    • Author(s)
      Ito H
    • Journal Title

      Annals of Nuclear Medicine 18

      Pages: 221-226

    • NAID

      10017669673

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Database of normal human cerebral blood flow, cerebral blood volume, cerebral oxygen extraction fraction and cerebral metabolic rate of oxygen measured by positron emission tomography with 150-labelled carbon dioxide or water, carbon monoxide and oxygen : a multicentre study in Japan2004

    • Author(s)
      Ito H
    • Journal Title

      European J Nuclear Medicine and Molecular Imaging 31

      Pages: 635-643

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] PET measurements of CBF, OEF, and CMRO2 without arterial sampling in hyperacute ischemic stroke : method and error analysis2004

    • Author(s)
      Ibaraki M
    • Journal Title

      Annals of Nuclear Medicine 18

      Pages: 35-44

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] PET measurements of CBF, OEF, and CMROZ without arterial sampling in hyperacute ischemic stroke : method and error analysis2004

    • Author(s)
      Ibaraki M
    • Journal Title

      Annals of Nuclear Medicine 18

      Pages: 35-44

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Database of normal human cerebral blood flow, cerebral blood volume, cerebral oxygen extraction fraction and cerebral metabolic rate of oxygen measured by positron emission tomography with 150-lablelled carbon dioxide or water, carbon monoxide and oxygen : a multicentre study in Japan2004

    • Author(s)
      Ito H
    • Journal Title

      European J Nuclear Medicine and Molecular Imaging 31

      Pages: 635-643

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Changes in human cerebral blood flow and myocardial blood flow during mental stress measured by dual positron emission tomography2003

    • Author(s)
      Ito H
    • Journal Title

      Annals of Nuclear Medicine 17

      Pages: 381-386

    • NAID

      10018370604

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Regional distribution of human cerebral vascular mean transit time measured by positron emission tomography2003

    • Author(s)
      Ito H
    • Journal Title

      Neuroimage 19

      Pages: 1163-1169

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Changes in human cerebral blood flow and cerebral blood volume during hypercapnia and hypocapnia measured by positron emission tomography2003

    • Author(s)
      Ito H
    • Journal Title

      J Cerebral Blood Flow and Metabolism 23

      Pages: 665-670

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Publications] Ito H, Kanno I, Kato C, Sasaki T, Ishii K, Ouchi Y, Iida A, Okazawa H, Hayashida K, Tsuyuguchi N, Ishii K, Kuwabara Y, Senda M: "Database of normal human cerebral blood flow, cerebral blood volume, cerebral oxygen extraction fraction and cerebral metabolic rate of oxygen measured by positron emission tomography with O-15-labelled carbon dioxide or water, carbon monoxide and oxygen : a multicentre study in Japan"European J Nuclear Medicine and Molecular Imaging. 17(in press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ito H, Kanno I, Hatazawa J, Miuura S: "Changes in human cerebral blood flow and myocardial blood flow during mental stress measured by dual positron emission tomography"Annals of Nuclear Medicine. 17. 381-386 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ito H, Kanno I, Takahashi K, Ibaraki M, Miura S: "Regional distribution of human cerebral vascular mean transit time measured by positron emission tomography"Neuroimage. 19. 1163-1169 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ito H, Kanno I, Ibaraki M, Hatazawa J, Miura S: "Changes in human cerebral blood flow and cerebral blood volume during hypercapnia and hypocapnia measured by positron emission tomography"J Cerebral Blood Flow and Metabolism. 23. 665-670 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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