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HBV vaccination for the reduction of therapeutic costs and for obtaining much more efficacy against HBV recurrence

Research Project

Project/Area Number 15591341
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

UEDA Mikiko  KYOTO UNIVERSITY, FACULTY OF MEDICINE, LECTURER, 医学研究科, 講師 (20322159)

Co-Investigator(Kenkyū-buntansha) TANAKA Koichi  KYOTO UNIVERSITY, FACULTY OF MEDICINE, PROFESSOR, 医学研究科, 教授 (20115877)
NABESHIMA Motoshige  KYOTO UNIVERSITY, FACULTY OF MEDICINE, ASSISTANT, 医学研究科, 助手 (80314178)
HAGA Hironori  KYOTO UNIVERSITY, FACULTY OF MEDICINE, ASSISTANT, 医学研究科, 助手 (10252462)
工藤 豊一郎  筑波大学, 大学院・人間総合科学研究科, 講師 (80324622)
Project Period (FY) 2003 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2004: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2003: ¥2,700,000 (Direct Cost: ¥2,700,000)
Keywordsliving donor liver transplantation / HBV hepatitis / recurrence of hepatitis / vaccination / transmission of hepatitis / reduction of therapeutic costs / immunosuppression / 肝炎再現
Research Abstract

Patients with hepatitis B virus related cirrhosis and patients who receive the liver grafts from HBcAb positive donors require constant injection of globulin containing high titer of HBsAb. To quit the injection of immunoglobulin, we adopted vaccination for HBV in these patients. The 'indicated patients for HBV vaccination were patients with negative HBeAg or HBMV-DNA patients who survive more than one year after liver transplantation with good liver functions controlled by immunosurressive agentsl such as FK506 or Cyclosporin A, solely, patients who can visit our hospital, and patients who give consents concerning this research protocols.
Patients who presented rejection, biliary vomplications, vascular complications and hepatitis in the passt six months, patients with recurrent livdr tumore after liver transplantation, patients who carries moderate or severe diseases, patients who shows allergy against HBV vaccine, patients with possible pregnancy, and patients whose doctor jugjec that the patients cannot receive vaccination, are excluded.
Ten patients are included in this study with the follow up period of one to ten months. One patients out of these ten patients showed increase in serum HBsAb above 1000 IU/L at six months after the initiation of vaccination. This phenomena was thought effective of vaccination. The other one patient showed seroconversion from HBsAb positive to HBsAg positive, probably due to quit of antiviral agent by himself. This patient was excluded from this study because of noncompliance. The other one patient became seropositive of HB-DNA three months after the initiation of this protocol, so that the study was quitted and immunoglobulin administration was reintroduced. The rest seven patients are on the way of the study.

Report

(3 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • Research Products

    (22 results)

All 2005 2004 Other

All Journal Article (20 results) Publications (2 results)

  • [Journal Article] Does hepatocellular carcinoma Reccure in any cases?2005

    • Author(s)
      Takada Y, et al.
    • Journal Title

      KAN TAN SUI 50(1)

      Pages: 141-146

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Prophylaxis of hepatitis B virus infection in Liver Transplantation2005

    • Author(s)
      Ueda M
    • Journal Title

      Transplantation Now 18(2)

      Pages: 176-178

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Immunosuppressive therapy of transplanted Patients for Autoimmune hepatic diseases.2005

    • Author(s)
      Ueda M
    • Journal Title

      The Medical Frontline 60(3)

      Pages: 97-103

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Portal vein complication in the long-term Course after pediatric living donor liver transplantation.2005

    • Author(s)
      Ueda M et al.
    • Journal Title

      Transplant Proc 37

      Pages: 1138-1140

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 肝細胞癌に対する生体肝移植とCLIP score2004

    • Author(s)
      上田幹子
    • Journal Title

      肝胆膵 48

      Pages: 194-198

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 肝細胞癌に対する治療:適応と予後2004

    • Author(s)
      江川裕人
    • Journal Title

      今日の移植 38

      Pages: 194-198

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] B型肝炎と肝移植2004

    • Author(s)
      上田幹子
    • Journal Title

      肝胆膵 49(4)

      Pages: 523-528

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] 肝移植におけるHBV感染とその防御2004

    • Author(s)
      朝隈光弘
    • Journal Title

      臨床消化器内科 19

      Pages: 1527-1533

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] 当科における肝癌に対する生体肝移植の成績2004

    • Author(s)
      上田幹子
    • Journal Title

      癌の臨床 50(11)

      Pages: 905-912

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Prevention of hepatitis B virus recurrence after living donor liver transplantation.2004

    • Author(s)
      Ali H
    • Journal Title

      Transplantation proceedings 36

      Pages: 2764-2767

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] A case of inflammatory pseudotumor of the liver hilum successfully treated with aggressive hepatectoy.2004

    • Author(s)
      Ueda M
    • Journal Title

      Journal of pediatric surgery 38

      Pages: 9-11

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Living donor liver transplantation for Hepatocellular carcinoma concerning the CLIP score2004

    • Author(s)
      Ueda M et al.
    • Journal Title

      KAN GAN SUI 48

      Pages: 194-198

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Treatment for the hepatocellular carcinoma : Indication and the prognosis2004

    • Author(s)
      Egawa H.
    • Journal Title

      Transplantation Now 38

      Pages: 194-198

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Hepatitis B and liver transplantation2004

    • Author(s)
      Ueda M
    • Journal Title

      KAN TAN SUI 49(4)

      Pages: 523-528

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Hepatitis B virus infection and its Prophylaxis in Liver transplantation.2004

    • Author(s)
      Asakuma M
    • Journal Title

      Clinical Gastroenterology 19

      Pages: 1527-1533

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Outcome of living donor liver transplantation for Hepatocellular carcinoma in Kyoto University Hospital.2004

    • Author(s)
      Ueda M
    • Journal Title

      Clinical Oncology 50(11)

      Pages: 905-912

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Living-donor liver transplantation for Polycystic liver disease.2004

    • Author(s)
      Ueda M et al.
    • Journal Title

      Transplantation 77

      Pages: 480-481

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Prevention of hepatitits B virus Recurrence after living donor liver transplantation2004

    • Author(s)
      Ali H et al.
    • Journal Title

      Transplantation Proceedings 36

      Pages: 2864-2767

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A Case of Inflammatory Pseudotumor Of the Liver Hilum Successfully Treated With Aggressive Hepatectomy2004

    • Author(s)
      Ueda M et al.
    • Journal Title

      Journal of Pediatric Surgery 38

      Pages: 9-11

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A case of inflammatory pseudotumor of the liver hilum successfully treated with aggressive hepatectomy.2004

    • Author(s)
      Ueda M
    • Journal Title

      Journal of pediatric surgery 38

    • Related Report
      2004 Annual Research Report
  • [Publications] 上田幹子: "肝細胞癌に対する生体肝移植とCLIP score"肝胆膵. 48. 27-33 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 江川裕人: "肝細胞癌に対する治療:適応と予後"今日の移植. 38. 194-198 (2004)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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