| Project/Area Number |
15591393
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | University of Fukui (2004)
福井医科大学 (2003) |
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Principal Investigator |
GOI Takanori University of Fukui, Faculty of Medical Sciences, Assistant, 医学部, 助手 (60225638)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAGUCHI Akio University of Fukui, Faculty of Medical Sciences, Professor, 医学部, 教授 (10174608)
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| Project Period (FY) |
2003 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 2004: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2003: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | Colorectal cancer / Angiogenesis / EG-VEGF / 肝転移 / EG-VEGF遺伝子 / 血管新生 |
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| Research Abstract |
Endocrine glands-derived-venous endothelial growth factor (EG-VEGF) was recently cloned as a new angiogenic factor that selectively acts on the endothelium of endocrine gland cells. The expression of EG-VEGF was comfirmed in all colorectal cancer cell lines. (On the other hand, the expression of EG-VEGF mRNA was not detected in colorectal normal mucosae.)
Tumor proliferation(cecum, s.c.) was significantly higher in the EG-VEGF transfectants than in the control cells. Also, Liver metastatic ratio was higher in the EG-VEGF transfectants than in the control cells. In this study, EG-VEGF may lead to angiogenesis, promoting cell proliferation, and liver metastasis in colorectal cancers. And When the EG-VEGF gene-overexpressing colorectal cancer cell line had been treated with phosphorothioate antisense EG-VEGF oligonucleotides, angiogenesis and tumor growth were inhibited. Angiogenesis factor EG-VEGF indicates that it is a cancer-specific and possibly tissue-specific angiogenesis factor in the large intestine, and suggests that it can be targeted by a novel anti angiogenesis therapy.
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