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Analysis of cytokine secretion in locally recurrent rectal cancer and host-immune enhancement by gene induction

Research Project

Project/Area Number 15591400
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionKyoto University

Principal Investigator

ONODERA Hisashi  Kyoto University, Department of Surgery, Associate Professor, 医学研究科, 助教授 (50240825)

Co-Investigator(Kenkyū-buntansha) NAGAYAMA Satoshi  Kyoto University, Department of Surgery, Instructor, 医学研究科, 助手 (70362499)
MORI Akira  Kyoto University, Department of Surgery, Instructor, 医学研究科, 助手 (60324646)
TSURUYAMA Tatsuaki  Kyoto University, Department of Pathology, Instructor, 医学研究科, 助手 (00303842)
Project Period (FY) 2003 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2004: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2003: ¥2,300,000 (Direct Cost: ¥2,300,000)
KeywordsColorectal cancer / Host immune defence / NKT cell / Hydrodynamic method / gene therapy / 大腸直腸癌 / hydrodynamics法 / 自然免疫
Research Abstract

Human invariant NKT cells are novel, distinct lymphocyte populations with a restricted T-cell receptor repertoire (Vα24-Vβ11). They play a pivotal role in immunoregulation and in anti-tumor activities. We focused on Vα24+NKT cells in colorectal carcinomas (CRC) and their clinicopathological significance. A total of 103 CRC cases were studied on Vα24+NKT cell infiltration immnohistochemically. The degree of NKT-cell infiltration in tumors was evaluated as low (<7 NKT cells/5 HPF) or high (【greater than or equal】7 NKT cells/5 HPF). The correlation between the degree of infiltrated Vα24+NKT cells and clinicopathological parameters was studied statistically. A small number of Vα24+NKT cells were found in the normal colorectal mucosa (2.6±3.7 cells/5HPF) ; however, their number increased remarkably in CRC (15.2±16.3/5HPF, P=0.0003). Higher NKT-cell infiltration was more frequent in women than in men (P=0.034) and correlated with fewer lymph node metastases (P=0.042). Patients with high NKT-cell infiltration showed higher overall (P=0.018) as well as disease-free (P=0.0006) survival rates. Intratumor NKT-cell infiltration was an independent prognostic factor for the overall (P=0.033) and disease-free (P=0.0064) survival rates. Increased infiltration of Vα24+NKT cells was observed in CRC. Higher Vα24+NKT cell infiltration in CRC was an independent prognostic factor for favorable prognosis. These results are important to create a new strategy against locally recurrent rectal cancer.

Report

(3 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report

Research Products

(18 results)

All 2004 2003 Other

All Journal Article (12 results) Publications (6 results)

  • [Journal Article] Indications and procedure for bladder augmentation following extended resection of intrapelvic organs.2004

    • Author(s)
      Onodera H et al.
    • Journal Title

      Proceedings of ISUCRS

      Pages: 121-125

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 最近の癌再発の診断法と治療法2004

    • Author(s)
      小野寺 久 他
    • Journal Title

      外科 66(3)

      Pages: 279-284

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 直腸癌局所再発-治療戦略とPitfall2004

    • Author(s)
      小野寺 久 他
    • Journal Title

      第2回兵庫大腸癌治療研究会記録集

      Pages: 15-24

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Pre-B lymphomas in SL/Kh mice : a multifactorial disease model.2003

    • Author(s)
      Hiai H et al.
    • Journal Title

      Cancer Sci. 94(10)

      Pages: 847-850

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Pre-B lymphomas in SL/Kh mice : a multifactorial disease model.2003

    • Author(s)
      Hiai H et al.
    • Journal Title

      Cancer Sci. 94-10

      Pages: 847-850

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Apoptosis rather than angiogenesis or proliferative activity is a useful prognostic factor in patients with resected liver metastases from colorectal cancer

    • Author(s)
      Onodera H et al.
    • Journal Title

      International Journal of Colorectal Diseases (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Reappraisal of Surgical Treatment for Radiation Enteritis

    • Author(s)
      Onodera H et al.
    • Journal Title

      World Journal of Surgery (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Apoptosis rather than angiogenesis or proliferative activity is a useful prognostic factor in patients with resected liver metastases from colorectal cancer

    • Author(s)
      Onodera H et al.
    • Journal Title

      International Journal of Colorectal Diseases (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Reappraisal of Surgical Treatment for Radiation Enteritis

    • Author(s)
      Onodera H et al.
    • Journal Title

      World Journal of Surgery (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Brain metastasis from colorectal cancer

    • Author(s)
      Onodera H et al.
    • Journal Title

      International Journal of Colorectal Diseases (in press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Reappraisal of Surgical Treatment for Radiation Enteritis

    • Author(s)
      Onodera H et al.
    • Journal Title

      World Journal of Surgery (in press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Apoptosis rather than angiogenesis or proliferative activity is a useful prognostic factor in patients with resected liver metastases from colorectal cancer

    • Author(s)
      Onodera H et al.
    • Journal Title

      International Journal of Colorectal Diseases (in press)

    • Related Report
      2004 Annual Research Report
  • [Publications] Hisashi Onodera et al.: "Novel surgical repair with bilateral gluteus muscle pathing for intractable rectovaginal fistula"Techniques in Coloproctology. 7. 198-202 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Hisashi Onodera et al.: "Weakness of anastomotic site in diabetic rats are caused by changes in the integrity of newly-formed collagen"Digestive Surgery. (in press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 小野寺 久ほか: "直腸癌再発例に対する治療方針-再切除を優先する立場から"Frontiers in Gastroenterology. 8. 26-30 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 小野寺 久ほか: "直腸癌治療の最前線-直腸癌局所再発に対する治療"外科治療. 86・4. 418-425 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 小野寺 久ほか: "直腸癌に対する最新の外科治療戦略-コンセンサスを得るためのたたき台提案"外科. 66・2. 203-208 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 小野寺 久ほか: "最近の癌再発の診断法と治療法 大腸癌・治療"外科. (印刷中).

    • Related Report
      2003 Annual Research Report

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Published: 2003-03-31   Modified: 2016-04-21  

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