Suppressive effect of hepatocyte growth factor on graft-versus-host disease in nonmyeloablative preparative regimen bone marrow transplantation for pancreatic carcinoma.
| Project/Area Number |
15591458
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Hyogo college of medicine |
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Principal Investigator |
KURODA Nobukazu Hyogo College of Medicine, Faculty of Medicine, Research Associate, 医学部, 助手 (20301658)
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| Co-Investigator(Kenkyū-buntansha) |
FUJIMOTO Jiro Hyogo College of Medicine, Faculty of Medicine, Professor, 医学部, 教授 (90199373)
IIMURO Yuji Hyogo College of Medicine, Faculty of Medicine, Associate Professor, 医学部, 助教授 (30252018)
HIRANO Tadamichi Hyogo College of Medicine, Faculty of Medicine, Research Associate, 医学部, 助手 (90340968)
IWASAKI Tsuyosi Hyogo College of Medicine, Faculty of Medicine, Associate Professor, 医学部, 助教授 (10151721)
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| Project Period (FY) |
2003 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2004: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2003: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | pancreatic cancer / nonmyeloablative preparative regimen / GVHD / HGF / GVT effect / hemopoietic stem cell / transplantation |
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| Research Abstract |
This study was designed to investigate the suppressive effect of HGF(hepatocyte growth factor) on GVHD(graft-versus-host disease) in nonmyeloablative preparative regimen bone marrow transplantation as the treatment of pancreatic cancer.
In original plan, the effect of HGF on GVHD suppression was determined by dose reduction of immunosuppressant agents. But it was thought to unable to determine whether the reduction of immunosuppressant agents was possible by HGF because of the deficiency of T cell and B cell.
So, we considered the laboratory model. We set the site of inplant of the cancer cell subcutaneous of the back of the SCID/B6 mouse. In this model, we determined the effect of HGF on GVHD and GVT effect.
After plantation of pancreatic cancer cells, bone marrow and lymphocytes of spleen were transplanted. And we determined the changes in the size of implanted tumor and GVHD effects on small intestine and liver.
Our data of GVT effect were scattering, and it was difficult to quantification of GVT effects. Although t is necessary to determine in more number of experimental model, it was confirmed that HGF may have possibilities to reduce the GVHD without reduction of GVT effect.
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Report
(3 results)
Research Products
(2 results)
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[Journal Article] Reversal of liver fibrosis.2004
Author(s)
Iimuro Y., Fujimoto J.
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Journal Title
State of Art of Hepatology : Molecular and Cell Biology (ed.H.E.Blum, and M.P.Manns)(Kluwer Academic Publishers BV, The Netherlands)
Pages: 113-121
Description
「研究成果報告書概要(欧文)」より
Related Report
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