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Quantitative evaluation of local biomechanics of thoracic aorta

Research Project

Project/Area Number 15591465
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionTohoku University

Principal Investigator

SAI Sadahiro  Tohoku University, Hospital, Lecturer, 病院, 講師 (60312576)

Co-Investigator(Kenkyū-buntansha) TABAYASHI Koichi  Tohoku University, Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (90142942)
SATO Masaaki  Tohoku University, Graduate School of Engineering, Professor, 大学院・工学研究科, 教授 (30111371)
SAIJO Yoshifumi  Tohoku University, Institute of Development Aging and Cancer, Associate Professor, 加齢医学研究所, 助教授 (00292277)
ODA Katsuhiko  Tohoku University, Graduate School of Medicine, Research Associate, 大学院・医学系研究科, 助手 (60323002)
熊谷 紀一郎  東北大学, 病院・医員
Project Period (FY) 2003 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2004: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2003: ¥2,200,000 (Direct Cost: ¥2,200,000)
KeywordsAortic aneurysm / Biomechanics / Intravascular ultrasound / Transesophageal echocardiography / Vascular wall / Tissue velocity / Macrophage / Inflammation / 超音波 / ストレイン / 超音波組織性状診断
Research Abstract

The objectives of the present study are to develop a quantitative measurement system of biomechanics of aortic wall by applying ultrasound diagnostics device and to establish an objective indication for rupture of aneurysm and operation. The concrete object of the research during grant-in-aid is to measure the local elasticity of aortic wall by using intravascular ultrasound (IVUS) and transesophageal echocardiography. (TEE)
Radio-frequency (RF) signal of clinical IVUS apparatus was sampled via analogue/digital (A/D) converter with sampling rate of 500 MSa/s and stored in a workstation. Electrocardiogram and intracoronary pressure were also sampled via A/D converter with 10 kSa/s, simultaneously. The correlation and displacement of RF lines of the same address in neighboring flames were calculated. Assuming that high correlation area indicated vascular wall, automatic recognition of vascular wall was performed. Tissue velocity was calculated as the difference of the frames was 33 ms. Tissue Velocity Imaging was defined as the tissue velocity in high correlation areas. Short axis view of descending aorta was obtained by a TEE with the central frequency of 4-7 MHz. Electrocardiogram and blood pressure were recorded simultaneously. Two dimensional tissue velocity, vectors were calculated by template matching method of squared region of interests in neighboring frames. IVUS findings and excised specimen by directional coronary atherectomy were compared and TEE findings and surgicaly excised specimen were compared The passive movement by blood pressure variance was correlated with tissue components and expression of inflammatory cells such as macrophages. Finally, precise measurement of biomechanics by applying ultrasonic technology was shown in the present research.

Report

(3 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • Research Products

    (20 results)

All 2005 2004 2003 Other

All Journal Article (11 results) Book (2 results) Publications (7 results)

  • [Journal Article] Spinal cord protection during thoracoabdominal aneurysm repair.2005

    • Author(s)
      Tabayashi K
    • Journal Title

      Surg Today 35・1

      Pages: 1-6

    • NAID

      10014259676

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Spinal cord protection during thoracoabdominal aneurysm repair.2005

    • Author(s)
      Tabayashi K.
    • Journal Title

      Surg Today 35(1)

      Pages: 1-6

    • NAID

      10014259676

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Acoustic properties of aortic aneurysm obtained with scanning acoustic microscopy.2004

    • Author(s)
      Saijo Y, Miyakawa T, Sasaki H, Tanaka M, Nitta S
    • Journal Title

      Ultrasonics 42・1-9

      Pages: 695-698

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Tissue velocity imaging of coronary artery by rotating-type intravascular ultrasound.2004

    • Author(s)
      Saijo Y, Tanaka A, Owada N, Akino Y, Nitta S
    • Journal Title

      Ultrasonics 42・1-9

      Pages: 753-757

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Quality of life elderly patients following thoracic aortic surgery.2004

    • Author(s)
      Oda K, Hata M, Tabayashi K et al.
    • Journal Title

      Jpn J Thorac Cardiovasc Surg 52・11

      Pages: 515-523

    • NAID

      10014386565

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Acoustic properties of aortic aneurysm obtained with scanning acoustic microscopy.2004

    • Author(s)
      Saijo Y, Miyakawa T, Sasaki H, Tanaka M, Nitta S.
    • Journal Title

      Ultrasonics 42(1-9)

      Pages: 695-698

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Tissue velocity imaging of coronary artery by rotating-type intravascular ultrasound.2004

    • Author(s)
      Saijo Y, Tanaka A, Owada N, Akino Y, Nitta S.
    • Journal Title

      Ultrasonics 42(1-9)

      Pages: 753-757

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Quality of life in elderly patients following thoracic aortic surgery.2004

    • Author(s)
      Oda K, Hata M, Kawatsu S, Adachi O, Yamaya K, Saiki Y, Sakurai M, Akasaka J, Iguchi A, Tabayashi K.
    • Journal Title

      Jpn J Thorac Cardiovasc Surg. 52(11)

      Pages: 515-523

    • NAID

      10014386565

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Quality of life in elderly patients following thoracic aortic surgery.2004

    • Author(s)
      Oda K, Hata M, Tabayashi K et al.
    • Journal Title

      Jpn J Thorac Cardiovasc Surg 52・11

      Pages: 515-523

    • NAID

      10014386565

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Use of cuffed anastomosis in total aortic arch replacement.2003

    • Author(s)
      Oda K, Akimoto H, Tabayashi K et al.
    • Journal Title

      Ann Thorac Surg 76・3

      Pages: 952-953

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Use of cuffed anastomosis in total aortic arch replacement.2003

    • Author(s)
      Oda K, Akimoto H, Hata M, Akasaka J, Yamaya K, Iguchi A, Tabayashi K.
    • Journal Title

      Ann Thorac Surg. 76(3)

      Pages: 952-953

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] Vascular Ultrasound2003

    • Author(s)
      Saijo Y, van der Steen AFW
    • Total Pages
      328
    • Publisher
      Springer
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] Vascular Ultrasound

    • Author(s)
      Saijo Y, van der Steen AFW eds.
    • Total Pages
      328
    • Publisher
      Springer
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Publications] Saijo Y, Hozumi N, Kobayashi K et al.: "Fast Fourier transform acoustic microscopy for biological tissues"Ultrasound Med Biol. 29・5s. S20-S20 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Saijo Y, Kobayashi K, Arai H et al.: "Pocket-size echo connectable to a personal computer"Ultrasound Med Biol. 29・5s. S54-S54 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Saijo Y, Tanaka A, Owada N et al.: "Intravascular tissue velocity imaging of coronary artery"Ultrasound Med Biol. 29・5s. S173-S173 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Takahashi G, Tabayashi K et al.: "MCI-186 prevents spinal cord damage and affects enzyme levels of nitric oxide synthase and Cu/Zn superoxide dismutase after transient ischemia in rabbits"J Thorac Cardiovasc Surg. 126. 1461-1466 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Oda K, Tabayashi K et al.: "Use of cuffed anastomosis in total aortic arch replacement"Ann Thorac Surg. 76. 952-953 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Moizumi Y, Tabayashi K et al.: "Clinical features and long-term outcome of type A and type B intramural hematoma of the aorta"J Thorac Cardiovasc Surg. 127. 421-427 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Saijo Y, van der Steen AFW: "Vascular Ultrasound"Springer-Verlaq. 328 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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