| Project/Area Number |
15591468
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
KAZUI Teruhisa Hamamatsu Univ.School of medicine, the 1^<st> surgery, professor, 医学部, 教授 (20094203)
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Takayasu Hamamatsu Univ.School of medicine, research assistant, 医学部, リサーチアシスタント (50397395)
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| Project Period (FY) |
2003 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2004: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 2003: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | cerebral protection / Edaravone / 8-OHdG / malondialdehyde / SEP / ASCP / old cerebral infarction / Total arch replacement / Antegrade cerebral perfusion / Cerebral protection / Cerebral infarction / Eduravone / MDA / 大動脈瘤 / 選択的脳灌流 / edaravon |
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| Research Abstract |
Objective :
We sought to examine the cerebral protective effects of prophylactically administered Edaravone, in a canine model of old cerebral infarction, undergoing an antegrade selective cerebral perfusion.
Methods :
A canine model of cerebral infarct was created by injecting a cylindrical silicone embolus in the middle cerebral artery. Animals that developed obvious neurological deficits and had survived for 4 weeks or more were included in the experimental group (n=5). Healthy mongrel dogs were used as control (n=5). Deep hypothermia with antegrade selective cerebral perfusion was performed in the control (non-Edaravone group : group A, Edaravone treated group : group B) and experimental (non-Edaravone group : group C, Edaravone treated group : group D)groups. Serum concentrations of 8-hydroxy-2'-deoxyguanosine (8-OHdG) and malondialdehyde (MDA) were measured, and central conduction time and amplitude ratio of somatosensory evoked potential were assessed during the procedure.
Result :
Both control and experimental groups had similar preoperative parameters. In group C, the serum concentrations of 8-OHdG and MDA, and the central conduction time increased significantly compared with those in group A and B. However the differences between group C and group D with regard to those parameters were not significant. The amplitude ratio in group C significantly decreased compared with that in the other groups.
Conclusion :
This experiment suggests that the prophylactic administration of Edaravone before antegrade selective cerebral perfusion is likely to provide effective cerebral protection in dogs with old cerebral infarction.
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